ABCG8
- Known as:
- ABCG8
- Catalog number:
- 000937A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ABCG8
Related genes to: ABCG8
- Gene:
- ABCG8 NIH gene
- Name:
- ATP binding cassette subfamily G member 8
- Previous symbol:
- -
- Synonyms:
- GBD4
- Chromosome:
- 2p21
- Locus Type:
- gene with protein product
- Date approved:
- 2000-12-12
- Date modifiied:
- 2019-04-23
Related products to: ABCG8
Related articles to: ABCG8
- Sijunzi decoction (SJZD) is a classic formula in traditional Chinese medicine (TCM) for the treatment of spleen deficiency syndrome (SDS). The chemical composition of SJZD mainly consists of polysaccharides (SJZDP), oligosaccharides (SJZD-OGS), and small-molecule components (SJZD-SMC) dominated by flavonoids, ginsenosides, and terpenoids. Studies have shown that SJZDP, SJZD-OGS, and SJZD-SMC form the material basis of SJZD's efficacy in ameliorating SDS, particularly by regulating gastrointestinal hormones, intestinal barrier function, and the gut microbiota. However, the underlying mechanism by which SJZD and its active components ameliorate SDS remains unclear. - Source: PubMed
Publication date: 2026/08/25
Chen XiaonanPu ZongjinLiu YixinZhang ZhengxuLi Xiaobo - Sitosterolemia is a rare autosomal recessive lipid disorder caused by biallelic pathogenic variants in ABCG5 or ABCG8, resulting in excessive intestinal absorption and impaired biliary excretion of plant sterols. Although historically considered exceptionally rare, recent genetic studies suggest the disorder is substantially underdiagnosed, with marked phenotypic heterogeneity ranging from xanthomas and premature atherosclerosis to hematologic abnormalities, and frequently mimics familial hypercholesterolemia. This review summarizes recent advances in the clinical, biological, and genetic diagnosis of sitosterolemia, with a focus on strategies that may facilitate earlier detection. - Source: PubMed
Publication date: 2026/08/19
Genoux AnneliseJamme ThibautMartinez Laurent O - Sitosterolemia is a rare autosomal recessive lipid disorder traditionally associated with hypercholesterolemia and xanthomas. However, hematologic abnormalities such as chronic thrombocytopenia and hemolytic anemia are increasingly recognized, often resulting in delayed diagnosis and inappropriate management. - Source: PubMed
Publication date: 2026/08/05
Gül-Bingöl Merveİşat EsraOcak SüheylaElverdi TuğrulÇınar-Özel SimgeCansever Mehmet ŞerifYıldırmak Zeynep YıldızÇeti̇nçeli̇k ÜmranTürkkan EmineUzunyayla GözdeEren TubaKıykım ErtuğrulAktuğlu-Zeybek ÇiğdemZubarioglu Tanyel - Severe hypercholesterolemia in children is commonly caused by familial hypercholesterolemia (FH); however, sitosterolemia, a rare autosomal recessive disorder, should be considered when FH genetic testing is negative. - Source: PubMed
Beacher DanielOtt AmyPlier Rebecca - In aviation and aerospace missions, personnel and astronauts are subjected to brief episodes of +Gz acceleration, resulting in overload stress that adversely affects the cardiovascular, respiratory, and nervous systems. This mechanical stress disrupts hemodynamic balance, tissue oxygenation, and physiological homeostasis. Increasing evidence links this stressor to hepatic injury; as the primary organ for drug metabolism, liver dysfunction may alter the expression and activity of drug-metabolizing enzymes and the pharmacokinetic profiles of circadian rhythm-regulating medications, such as modafinil. This study systematically evaluates the effects of repeated brief + Gz exposure on hepatic drug-metabolizing enzymes and modafinil pharmacokinetics using a murine model. - Source: PubMed
Publication date: 2026/08/03
Liu FengzhouShen HuiWan QunLi YajuanZhao GangLiu XiaoLin WeiXue Junhui