ABCD2
- Known as:
- ABCD2
- Catalog number:
- 000926A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ABCD2
Related genes to: ABCD2
- Gene:
- ABCD2 NIH gene
- Name:
- ATP binding cassette subfamily D member 2
- Previous symbol:
- ALDL1
- Synonyms:
- ALDR, ALDRP
- Chromosome:
- 12q12
- Locus Type:
- gene with protein product
- Date approved:
- 1997-10-10
- Date modifiied:
- 2015-11-13
Related products to: ABCD2
Related articles to: ABCD2
- Current carotid revascularization paradigms are primarily stenosis-based, with optimized medical therapy (OMT) alone generally recommended for symptomatic patients with (≤50%) mild to moderate stenosis (MMDS) and no routine recommendation for revascularization, despite evidence of potentially high-risk plaque features beyond stenosis. We aimed to contrast clinical presentation, prevalence of vulnerable plaque features, and post-revascularization outcomes among symptomatic patients with MMDS and high-degree stenosis (HDS>50%) across three stroke centers. - Source: PubMed
Publication date: 2026/08/09
Polania-Sandoval CamiloMeschia James FKumar GyanendraBrown Robert DBendok Bernard RBarrett Kevin MSanchez-Calderin DiegoInal EkinEsquetini-Vernon CamilaMiller David AFox W ChristopherJacobs ChristopherSandhu Sukhwinder J SBeegle Richard DFarres HoussamLanzino GiuseppeErben Young - Despite the fact that acute persistent vertigo can be a presenting sign of stroke, early bedside risk assessment continues to be particularly difficult. In order to predict clinically detected strokes among patients who were experiencing acute persistent vertigo, our objective was to create and internally validate a multivariable model. Additionally, we wanted to evaluate the model's performance in comparison to scores that are routinely utilized. - Source: PubMed
Publication date: 2026/06/24
Ba YueLiu BinZhu Pinyi - Transient ischemic attack (TIA) is a neurological emergency associated with a substantial early risk of ischemic stroke, yet its diagnosis remains clinically challenging because objective biomarkers are limited. Glycoprotein VI (GPVI), a platelet collagen receptor involved in platelet activation and thrombus formation, may reflect prothrombotic activity in cerebrovascular ischemia. This study aimed to evaluate the diagnostic assessment and short-term risk stratification value of serum GPVI levels in patients presenting to the emergency department with suspected TIA. This prospective observational cohort study included 85 adult patients with transient focal neurological symptoms suggestive of TIA. Patients were classified according to the Precise Diagnostic Score (PREDISC), and early stroke risk was assessed using the ABCD2 score. Serum GPVI levels were measured using enzyme-linked immunosorbent assay. Patients were followed for cerebrovascular events at 2 and 7 days. Associations between GPVI levels, clinical scores, and early outcomes were analyzed, and diagnostic performance was assessed using receiver operating characteristic analysis. Serum GPVI levels differed significantly across PREDISC categories and increased from the "TIA unlikely" group to the "TIA very likely" group ( < 0.001). GPVI levels were also higher in patients with ABCD2 scores ≥4 than in those with lower scores ( < 0.001). GPVI showed positive correlations with both PREDISCs (Spearman's r = 0.682, = 0.001) and ABCD2 scores (Spearman's r = 0.469, = 0.001). All early cerebrovascular events occurred in the high-risk ABCD2 group. Patients who experienced cerebrovascular events had higher baseline GPVI levels, with a small-to-moderate effect size for 2-day outcomes (r = 0.22) and a moderate effect size for 7-day outcomes (r = 0.36). ROC analysis demonstrated discriminative performance for identifying patients classified as "TIA very likely" according to the PREDISC system, with an area under the curve of 0.821 (95% CI: 0.71-0.91). Serum GPVI levels were associated with PREDISC-based clinical TIA likelihood, higher ABCD2-defined risk categories, and early cerebrovascular events in patients with suspected TIA. These findings suggest that GPVI may have a potential complementary role within structured emergency department-based diagnostic assessment and short-term risk stratification frameworks, pending validation in larger independent cohorts. However, because of the exploratory single-center design, modest sample size, limited number of outcome events, and absence of external validation, these findings should be interpreted as hypothesis-generating and require confirmation in larger multicenter studies. - Source: PubMed
Publication date: 2026/05/30
Gençer ÖmerSayhan Mustafa BurakGokdemir Mehmet TahirÇeliktürk ErayBozatlı Satuk Buğra HanSerttaş Rıza - Transient ischemic attack (TIA) often precedes the ischemic stroke and, therefore, requires urgent treatment, whereas transient global amnesia (TGA) is a benign condition but often causes concern to patients and their relatives. The longitudinal prognosis of TIA or TGA has not recently been reported in Finland. In this study, we studied the 5-year prognosis of TIA and TGA concerning especially stroke, TIA, and mortality. - Source: PubMed
Publication date: 2026/05/19
Komulainen TiinaKoivisto AnneKärkkäinen VirveSelander TuomasBärlund VenlaTanila HeikkiJäkälä Pekka - BACKGROUND: Ischemic stroke (IS) is a major public health challenge. Transient ischemic attack (TIA) serves as a critical warning sign, particularly in hypertensive patients where early risk stratification remains difficult. While ambulatory blood pressure monitoring (ABPM) parameters strongly associated with cerebrovascular events, their predictive value for post-TIA stroke in hypertension is unclear. This study evaluated ABPM parameters for predicting 90-day acute IS risk in hypertensive TIA patients. METHODS: This single-center retrospective cohort included 1,276 hypertensive patients with TIA. All underwent 24-hour ABPM within 48 h. The outcome was IS within 90 days. LASSO regression selected key variables from 20 ABPM indices. Their independent association with IS was assessed using multivariable Cox regression across four progressively adjusted models. Predictive performance was evaluated via receiver operator characteristic curve (ROC) curves, nonlinearity via restricted cubic splines (RCS), and robustness via subgroup analyses. RESULTS: LASSO identified five key variables: nighttime systolic blood pressure variability (nSBPCV), daytime systolic blood pressure load (dSBPL), morning blood pressure surge (MBPS), nighttime systolic blood pressure (nSBP) and duration of hypertension. After all the adjustments, these variables remained independent risk factors for the occurrence of IS within 90 days in patients with a history of hypertension who suffered from TIA (all P < 0.001). nSBPCV (AUC = 0.834) and dSBPL (AUC = 0.804) outperformed the ABCD2 score (AUC = 0.685). RCS revealed nonlinear association for hypertension duration, nSBPCV, and dSBPL with clear inflection points (5.9 years, 9.1%, 37.3%). Results were consistent across subgroups. CONCLUSIONS: In hypertensive TIA patients, ABPM-derived parameters, especially nSBPCV and dSBPL, are strong predictors of 90-day IS risk, superior to ABCD2. The identified nonlinear relationships and inflection points provide actionable thresholds for personalized risk stratification and precise blood pressure management. - Source: PubMed
Publication date: 2026/04/16
Wang BoZhang YunpengWang XueyingWang YanPan RunzhouLu Hui