ABCC13
- Known as:
- ABCC13
- Catalog number:
- 000920A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ABCC13
Related genes to: ABCC13
- Gene:
- ABCC13 NIH gene
- Name:
- ATP binding cassette subfamily C member 13 (pseudogene)
- Previous symbol:
- -
- Synonyms:
- PRED6, C21orf73, ABCC13P
- Chromosome:
- 21q11.2
- Locus Type:
- pseudogene
- Date approved:
- 2002-11-11
- Date modifiied:
- 2018-10-17
Related products to: ABCC13
Related articles to: ABCC13
- The widespread application of glyphosate has resulted in the evolution of glyphosate resistance in Lolium rigidum. This study investigated the resistance mechanism in an Australian population of L. rigidum, designated WALR60. Transcriptome sequencing coupled with quantitative real-time PCR (qRT-PCR) analyses identified significant upregulation of ABCC3.2, ABCB11, and ABCC13 in the WALR60 population compared to susceptible controls. Structural analysis revealed that LrABCC3.2 lacks the N-terminal TMD0 domain present in its homolog LrABCC3.1, representing a core ABC transporter. LrABCC3.2-transformed yeast cells exhibited enhanced tolerance to glyphosate, as compared to the empty vector control. Similarly, rice calli and seedlings overexpressing ABCC3.2 (ABCC3.2-OE) showed increased glyphosate resistance relative to the corresponding GFP-overexpressing (GFP-OE) controls. Additionally, the LrABCC3.2-OE lines displayed resistance to haloxyfop and pinoxaden. Integrative transcriptomic and metabolomic analyses of transgenic rice revealed that LrABCC3.2 overexpression significantly enriches the glycerophospholipid metabolism pathway, with positive correlations between the expression of GPAT3, PLDĪ±2, PLA14 and the accumulation of phosphatidylcholine (PC) and choline. Comparative transcriptome analysis between resistant L. rigidum and LrABCC3.2-OE rice identified 10 commonly upregulated and 18 commonly downregulated genes, indicating a conserved detoxification mechanism. In conclusion, this study demonstrates that ABCC3.2 overexpression contributes to glyphosate resistance in the WALR60 population and elucidates a potential downstream metabolic pathway involved in this trait. - Source: PubMed
Publication date: 2026/07/26
Ouyang YulanYing JinfengZeng YalinQi JialeLiu ZhanghuiPan Lang - Selenium-enriched foxtail millet () represents a functional cereal with significant health benefits for humans. This study endeavors to examine the impact of foliar application of sodium selenite (NaSeO) on foxtail millet, specifically focusing on selenium (Se) accumulation and transportation within various plant tissues. - Source: PubMed
Publication date: 2024/03/11
Wen YinyuanCheng LiunaZhao ZeyaAn MengyaoZhou ShixueZhao JuanDong ShuqiYuan XiangyangYin Meiqiang - Ground glass hepatocytes (GGHs) have been associated with hepatocellular carcinoma (HCC) recurrence and poor prognosis. We previously demonstrated that pre-S expression in some GGHs is resistant to current hepatitis B virus (HBV) antiviral therapies. This study aimed to investigate whether integrated HBV DNA (iDNA) is the primary HBV DNA species responsible for sustained pre-S expression in GGH after effective antiviral therapy. We characterized 10 sets of micro-dissected, formalin-fixed-paraffin-embedded, and frozen GGH, HCC, and adjacent hepatitis B surface antigen-negative stained tissues for iDNA, pre-S deletions, and the quantity of covalently closed circular DNA. Eight patients had detectable pre-S deletions, and nine had detectable iDNA. Interestingly, eight patients had integrations within the TERT and CCNE1 genes, which are known recurrent integration sites associated with HCC. Furthermore, we observed a recurrent integration in the ABCC13 gene. Additionally, we identified variations in the type and quantity of pre-S deletions within individual sets of tissues by junction-specific PacBio long-read sequencing. The data from long-read sequencing indicate that some pre-S deletions were acquired following the integration events. Our findings demonstrate that iDNA exists in GGH and can be responsible for sustained pre-S expression in GGH after effective antiviral therapy. - Source: PubMed
Su Yih-PingLin Selena YSu Ih-JenKao Yu-LanShen Shih-ChunEarl Joshua PEhrlich Garth DChen Cheng-YiHuang WenyaSu Ying-HsiuTsai Hung-Wen - It is an important way for healthy Selenium (Se) supplement to transform exogenous Se into organic Se through crops. In the present study, was selected as a test material and sprayed with biological nano selenium (SeNPs) and NaSeO, and its nutrient composition, antioxidant capacity, total Se and organic Se content were determined, respectively. Further, the response of ABC transporter family members in cowpea to different exogenous Se treatments was analyzed by transcriptome sequencing combined with different Se forms. The results show that the soluble protein content of cowpea increased after twice Se treatment. SeNPs treatment increased the content of cellulose in cowpea pods. NaSeO treatment increased the content of vitamin C (Vc) in cowpea pods. Se treatments could significantly increase the activities of Peroxidase (POD), polyphenol oxidase (PPO) and catalase (CAT) in cowpea pods and effectively maintain the activity of Superoxide dismutase (SOD). SeNPs can reduce the content of malondialdehyde (MDA) in pods. After Se treatment, cowpea pods showed a dose-effect relationship on the absorption and accumulation of total Se, and NaSeO treatment had a better effect on the increase of total Se content in cowpea pods. After treatment with SeNPs and NaSeO, the Se species detected in cowpea pods was mainly SeMet, followed by MeSeCys. Inorganic Se can only be detected in the high concentration treatment group. Analysis of transcriptome data of cowpea treated with Se showed that ABC transporters could play an active role in response to Se stress and Se absorption, among which ABCB, ABCC and ABCG subfamilies played a major role in Se absorption and transportation in cowpea. Further analysis by weighted gene co-expression network analysis (WGCNA) showed that the content of organic Se in cowpea treated with high concentration of SeNPs was significantly and positively correlated with the expression level of three transporters ABCC11, ABCC13 and ABCC10, which means that the ABCC subfamily may be more involved in the transmembrane transport of organic Se in cells. - Source: PubMed
Publication date: 2023/02/01
Li LiXiong YuzhouWang YuanWu ShuaiXiao ChunmeiWang ShiyanCheng ShuiyuanCheng Hua - Immunoglobulin-G4-related disease (IgG4-RD) is a distinct systemic autoimmune-mediated disease manifesting as chronic inflammation and tissue fibrosis. Since the role of DNA methylation in the pathogenesis of IgG4-RD is still unclear, we conduct this study to investigate epigenetic modifications in IgG4-RD. - Source: PubMed
Publication date: 2023/01/07
Wu XunyaoWang AnqiWang MuPeng YuChen YingyingLi JieqiongLiu ZhengLu HuiZhou JiaxinPeng LinyiZhao YanZeng XiaofengFei YunyunZhang Wen