ABCC13
- Known as:
- ABCC13
- Catalog number:
- 000920A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ABCC13
Related genes to: ABCC13
- Gene:
- ABCC13 NIH gene
- Name:
- ATP binding cassette subfamily C member 13 (pseudogene)
- Previous symbol:
- -
- Synonyms:
- PRED6, C21orf73, ABCC13P
- Chromosome:
- 21q11.2
- Locus Type:
- pseudogene
- Date approved:
- 2002-11-11
- Date modifiied:
- 2018-10-17
Related products to: ABCC13
Related articles to: ABCC13
- Selenium-enriched foxtail millet () represents a functional cereal with significant health benefits for humans. This study endeavors to examine the impact of foliar application of sodium selenite (NaSeO) on foxtail millet, specifically focusing on selenium (Se) accumulation and transportation within various plant tissues. - Source: PubMed
Publication date: 2024/03/11
Wen YinyuanCheng LiunaZhao ZeyaAn MengyaoZhou ShixueZhao JuanDong ShuqiYuan XiangyangYin Meiqiang - Ground glass hepatocytes (GGHs) have been associated with hepatocellular carcinoma (HCC) recurrence and poor prognosis. We previously demonstrated that pre-S expression in some GGHs is resistant to current hepatitis B virus (HBV) antiviral therapies. This study aimed to investigate whether integrated HBV DNA (iDNA) is the primary HBV DNA species responsible for sustained pre-S expression in GGH after effective antiviral therapy. We characterized 10 sets of micro-dissected, formalin-fixed-paraffin-embedded, and frozen GGH, HCC, and adjacent hepatitis B surface antigen-negative stained tissues for iDNA, pre-S deletions, and the quantity of covalently closed circular DNA. Eight patients had detectable pre-S deletions, and nine had detectable iDNA. Interestingly, eight patients had integrations within the TERT and CCNE1 genes, which are known recurrent integration sites associated with HCC. Furthermore, we observed a recurrent integration in the ABCC13 gene. Additionally, we identified variations in the type and quantity of pre-S deletions within individual sets of tissues by junction-specific PacBio long-read sequencing. The data from long-read sequencing indicate that some pre-S deletions were acquired following the integration events. Our findings demonstrate that iDNA exists in GGH and can be responsible for sustained pre-S expression in GGH after effective antiviral therapy. - Source: PubMed
Su Yih-PingLin Selena YSu Ih-JenKao Yu-LanShen Shih-ChunEarl Joshua PEhrlich Garth DChen Cheng-YiHuang WenyaSu Ying-HsiuTsai Hung-Wen - It is an important way for healthy Selenium (Se) supplement to transform exogenous Se into organic Se through crops. In the present study, was selected as a test material and sprayed with biological nano selenium (SeNPs) and NaSeO, and its nutrient composition, antioxidant capacity, total Se and organic Se content were determined, respectively. Further, the response of ABC transporter family members in cowpea to different exogenous Se treatments was analyzed by transcriptome sequencing combined with different Se forms. The results show that the soluble protein content of cowpea increased after twice Se treatment. SeNPs treatment increased the content of cellulose in cowpea pods. NaSeO treatment increased the content of vitamin C (Vc) in cowpea pods. Se treatments could significantly increase the activities of Peroxidase (POD), polyphenol oxidase (PPO) and catalase (CAT) in cowpea pods and effectively maintain the activity of Superoxide dismutase (SOD). SeNPs can reduce the content of malondialdehyde (MDA) in pods. After Se treatment, cowpea pods showed a dose-effect relationship on the absorption and accumulation of total Se, and NaSeO treatment had a better effect on the increase of total Se content in cowpea pods. After treatment with SeNPs and NaSeO, the Se species detected in cowpea pods was mainly SeMet, followed by MeSeCys. Inorganic Se can only be detected in the high concentration treatment group. Analysis of transcriptome data of cowpea treated with Se showed that ABC transporters could play an active role in response to Se stress and Se absorption, among which ABCB, ABCC and ABCG subfamilies played a major role in Se absorption and transportation in cowpea. Further analysis by weighted gene co-expression network analysis (WGCNA) showed that the content of organic Se in cowpea treated with high concentration of SeNPs was significantly and positively correlated with the expression level of three transporters ABCC11, ABCC13 and ABCC10, which means that the ABCC subfamily may be more involved in the transmembrane transport of organic Se in cells. - Source: PubMed
Publication date: 2023/02/01
Li LiXiong YuzhouWang YuanWu ShuaiXiao ChunmeiWang ShiyanCheng ShuiyuanCheng Hua - Immunoglobulin-G4-related disease (IgG4-RD) is a distinct systemic autoimmune-mediated disease manifesting as chronic inflammation and tissue fibrosis. Since the role of DNA methylation in the pathogenesis of IgG4-RD is still unclear, we conduct this study to investigate epigenetic modifications in IgG4-RD. - Source: PubMed
Publication date: 2023/01/07
Wu XunyaoWang AnqiWang MuPeng YuChen YingyingLi JieqiongLiu ZhengLu HuiZhou JiaxinPeng LinyiZhao YanZeng XiaofengFei YunyunZhang Wen - Glioblastoma (GBM) is the most common and aggressive malignant primary brain tumors in adults. Patients invariably relapse during or after first-line therapy and the median overall survival is 14.6 months. Such poor clinical response is partly ascribed to the activity of ATP-binding cassette (ABC) transporters. The activity of these proteins, severely reduces the amount of therapeutics that penetrates the tumor cells. We hypothesized that ABC transporter expression could correlate with survival surrogates. In this study, we assessed the expression of four commonly expressed ABC transporters in GBM samples and investigated if mRNA levels could serve as a prognostic biomarker. - Source: PubMed
Publication date: 2022/11/07
Roy Laurent-OlivierLemelin MyriamBlanchette MariePoirier Marie-BelleAldakhil SalmanFortin David