ABCC4
- Known as:
- ABCC4
- Catalog number:
- 000910A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ABCC4
Related genes to: ABCC4
- Gene:
- ABCC4 NIH gene
- Name:
- ATP binding cassette subfamily C member 4
- Previous symbol:
- -
- Synonyms:
- MRP4, EST170205, MOAT-B, MOATB
- Chromosome:
- 13q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-10-26
- Date modifiied:
- 2019-04-23
Related products to: ABCC4
Related articles to: ABCC4
- High-altitude environments, characterized by hypoxia, intense ultraviolet radiation, and low temperatures, pose major challenges to livestock survival. In recent years, researchers have gradually uncovered adaptive mechanisms in livestock across different altitudes using whole-genome resequencing. Previous studies of goat altitude adaptation have been limited by small breed numbers and low sequencing depth, hindering comprehensive exploration of adaptive mechanisms across different altitudes. This study analyzed whole-genome resequencing data from 151 individuals across 17 goat breeds representing three distinct altitude gradients (high, middle, and low). Using both SNPs and structural variations (SVs), we characterized population relationships, gene flow, and the SV landscape, including QTL-SV associations and transposable element interactions. Selective sweep analyses using F, θπ ratio, XP-CLR, XP-EHH, and LFMM identified several candidate genes associated with altitude adaptation, including , , , and , which were significantly enriched in pathways related to hypoxia response, oxidative stress, energy metabolism, angiogenesis, and nervous system regulation. Notably, showed ABCC4 showed recurrent candidate selection signals in both SNP and SV analyses, suggesting its potential involvement in altitude adaptation. These findings provide multi-level genomic evidence for goat adaptation to high-altitude stress and provide important insights into the adaptive evolution of goats. - Source: PubMed
Publication date: 2026/07/13
Li WenzeSu YixinLiu CanLin XiaokunXue ShanhuiBadaoui BouabidYan XiaochunLv QiSu Rui - Brain microvascular endothelial cells (BMECs) form the blood-brain barrier (BBB), a highly selective interface that restricts paracellular diffusion and regulates the transport of nutrients and drugs into the central nervous system via specialized transporters and receptors. Tight junction-associated protein 1 (Tjap1), also termed protein incorporated later into tight junctions (Pilt), has been localized to tight junctions (TJs) in epithelial cells and to the trans-Golgi network in fibroblasts; however, its expression, subcellular localization, and functional significance in BMECs are still unknown. We characterized Tjap1 subcellular localization in mouse and human BMEC cell lines as well as primary mouse BMECs by immunofluorescence with and without pharmacological Golgi disruption by treatment with Brefeldin A, Golgicide A or Pitstop 2. CRISPR/Cas9-mediated Tjap1 knockout cells were generated and examined with regard to their Golgi morphology using immunostaining. Tjap1 mRNA localization was examined by RNAscope in situ hybridization. Quantitative real-time PCR and Western blot was performed to assess the expression of BBB-associated efflux transporters, solute carrier transporters, and cellular receptors in control and Tjap1 knockout cells. Tjap1 predominantly localized to the cis-Golgi compartment, co-localizing with Gm130 rather than Tgn38, and was absent from TJs in BMECs. Tjap1 knockout induced pronounced Golgi fragmentation BMECs. Importantly, Tjap1 knockout significantly downregulated mRNA-expression of Abcb1a, Abcb1b, Abcc4, Slc2a1, Slc7a1, Slc7a5 and Tfrc, while Abcg2 was upregulated. At the protein level, a decrease in the protein levels of Abcb1, Abcc4, Slc2a1, Slc7a1, and Tfrc was observed in Tjap1 knockout cEND cells. In BMECs, Tjap1 is a cis-Golgi-associated protein required for the structural integrity of the Golgi apparatus. Its deletion is associated with Golgi fragmentation and significant alterations in the mRNA and protein expression of drug transporters and receptors at the BBB. These findings identify Tjap1 as a candidate regulator of both Golgi architecture and the BBB transporter profile in vitro, with potential implications for modulating drug transport across the BBB. - Source: PubMed
Publication date: 2026/05/28
Mi JunqiaoSchoder AnnabelleSun AiliMeybohm PatrickBurek Malgorzata - Copy number variation (CNV) is an important class of structural variations (SVs) that contribute to phenotypic diversity and environmental adaptation in animals. However, large-scale population-level analyses of CNVs in goats remain limited. This study aimed to comprehensively characterize CNVs and explore their potential roles in economically important traits in Chinese goat populations. - Source: PubMed
Publication date: 2026/05/30
Li WenzeSu YixinLiu CanYan XiaochunLv QiSu Rui - Although methotrexate (MTX) is extensively utilized in management of rheumatoid arthritis (RA), its pharmacogenomics are still unclear. This study explores the genetic determinants impacting MTX's effectiveness and adverse effects in Taiwanese patients with RA, aiming to enhance understanding of RA treatment and pharmacogenetics. A retrospective analysis of 1,948 RA patients receiving MTX treatment from January 2009 to January 2022, using data from the Taiwan Precision Medicine Initiative (TPMI) at Taichung Veterans General Hospital. Among these patients, 872 who required treatment with biologic disease modifying anti-rheumatic drugs (bDMARDs) or targeted synthetic DMARDs (tsDMARDs) were classified as MTX 'non-response', while the 1,076 patients treated without these agents were categorized as MTX 'response'. Chi-square analysis was employed to compare the carrier ratio of 82 selected MTX-associated SNPs from previous literature. Logistic regression models were utilized to explore associations between genetic variants and the risk of non-response and adverse effects, with adjustments made for potential confounding factors. Significant genetic markers influencing MTX response included ABCC1 rs212090, which predicted better MTX efficacy (p = 0.016), and ABCC3 rs2277624 and rs4148416, linked to lower MTX response rates (p = 0.004 and p = 0.023). SNPs in ADORA3 rs2298191 and ABCC4 rs7317112 were linked to a higher risk of thrombocytopenia (p = 0.045 and p = 0.049). Our study identifies genetic variations ABCC1 and ABCC3 related to MTX efficacy in treating RA, while SNPs in ADORA3 and ABCC4 are associated with the side effect of thrombocytopenia. These insights offer a foundation for tailoring individual treatment plans based on genetic profiles. - Source: PubMed
Publication date: 2026/06/09
Yu Ta-WeiChen I-ChiehLin Guan-ChengKao Chung-MaoChen Yen-JuChen Yi-Ming - Sleep deprivation is a common phenomenon in modern society and has received widespread attention. However, data about its impact on immune system functions remains scant. - Source: PubMed
Li XiangWang XiaoyanWang XiaodiBing Dan