ABCB9
- Known as:
- ABCB9
- Catalog number:
- 000903A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ABCB9
Related genes to: ABCB9
- Gene:
- ABCB9 NIH gene
- Name:
- ATP binding cassette subfamily B member 9
- Previous symbol:
- -
- Synonyms:
- EST122234
- Chromosome:
- 12q24.31
- Locus Type:
- gene with protein product
- Date approved:
- 1999-10-26
- Date modifiied:
- 2016-10-04
Related products to: ABCB9
Related articles to: ABCB9
- Crohn's disease (CD) is a chronic inflammatory condition of the gastrointestinal tract, where oxidative stress is a significant contributing factor to its pathogenesis. This study utilized multi-omics data, including RNA sequencing from the GSE216447 dataset and three genome-wide association studies (GWAS) datasets (ieu-a-10, ieu-a-11, ieu-a-13), to investigate the molecular networks related to oxidative stress in CD. Differential expression analysis was performed using DESeq2, followed by pathway enrichment analysis with clusterProfiler. Protein-protein interaction (PPI) networks were constructed using the STRING database. Mendelian Randomization (MR) analysis was conducted using TwoSampleMR and MRMix to identify causal relationships between genetic variants and CD. Quantitative real-time polymerase chain reaction (qPCR) was further applied to verify key differentially expressed genes (DEGs), including FASN, HMGCR, ASCC3, CD101, ELOVL6, PHLDA2, PHLDA3, and SCPEP1, in intestinal mucosal samples from both inactive and active CD patients. The analysis identified 64 up-regulated and 46 down-regulated differentially expressed genes (DEGs) in response to HO intervention. Key pathways related to oxidative stress, including the p53 signalling pathway and steroid biosynthesis, were significantly enriched. Consistent with transcriptomic data, qPCR confirmed that FASN and HMGCR were significantly upregulated in inactive CD, while ASCC3, CD101, ELOVL6, PHLDA2, PHLDA3, and SCPEP1 were markedly increased in active CD (all p < 0.05). The MR analysis revealed that in the dataset ieu-a-10, ABCB9 and OSGIN1 were identified as having a significant causal relationship with CD using TwoSampleMR, while only OSGIN1 was significant in MRMix. In dataset ieu-a-11, ARL4C, CD101, HMGCR, and IL24 were found to be significantly associated with CD, with overlapping findings between TwoSampleMR and MRMix. For dataset ieu-a-13, ACTA2 and CD101 were consistently identified as significant, suggesting their potential roles in CD pathogenesis. The findings highlight the crucial involvement of oxidative stress-related molecular networks in CD and underscore the utility of Mendelian Randomization in elucidating causal genetic factors. qPCR validation confirmed persistent upregulation of lipid metabolism genes in inactive CD and significant elevation of inflammation-related genes in active CD, reinforcing the link between oxidative stress and disease activity. - Source: PubMed
Yang JuanZhang LidaWang XiaqingYang Yuxiu - Crop plants have to deal with long-term cadmium exposure to farmlands contaminated by intensive use of fertilizers and pesticides. For uptake and sequestration, Cd has to pass the plasma membrane and tonoplast. Class III peroxidases, plasma membrane, and tonoplast sub-proteomes were studied. - Source: PubMed
Publication date: 2026/02/25
Lüthje SabineYilmaz Ayse GülRamanathan KalaivaniGräfenstein WaldemarTabbert Jenny MWienkoop StefanieHeino KatrinPerrineau François ClementHarder Sönke - Intrahepatic cholangiocarcinoma (iCCA) is an aggressive malignancy characterized by profound molecular heterogeneity and poor prognosis. Programmed cell death (PCD) regulates tumor progression and shapes the tumor immune microenvironment (TME), yet the roles of distinct PCD subtypes in iCCA remain elusive. Here, we integrated bulk and single-cell transcriptomic datasets derived exclusively from intrahepatic cholangiocarcinoma (iCCA) in TCGA, GEO, and the fan_match cohort, and curated genes representing 21 PCD subtypes. Among 117 machine-learning algorithm combinations, a backward stepwise Cox regression (StepCox) combined with random survival forests (RSF) constructed a robust nine-gene prognostic signature (ATF6, ACVR1, ACAP2, C6orf136, CD4, ABCB9, ABCC1, CSNK2A2, ABCG1) that consistently stratified patients into high- and low-risk groups with distinct outcomes across independent cohorts. High-risk patients exhibited inferior survival, greater immunosuppressive features, elevated TME scores, and enrichment of inflammatory pathways. The PCD score demonstrated predictive value for immunotherapy response across multiple independent cohorts. Single-cell analyses further revealed increased regulatory T-cell infiltration and more complex intercellular communication in high-risk tumors, whereas low-risk tumors displayed stronger collagen signaling and a less immunosuppressive tumor immune microenvironment. Collectively, these findings underscore the importance of PCD-related genes for prognosis and for predicting immunotherapy response in iCCA, and provide a practical framework for risk stratification and therapeutic decision-making. - Source: PubMed
Publication date: 2026/03/16
Zhang TiancaiDou DongqingLiu QiXu DongWang TongLiu RongLu DanyangZhao XiaofangWang SenyanZhang Huapeng - Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting millions worldwide. While advances in single-cell technologies have elucidated cellular diversity and transcriptional changes in AD, the contribution of transposable elements (TEs) to disease pathogenesis remains poorly understood. - Source: PubMed
Publication date: 2026/01/07
Kumar VikasBeck Samuel - High-fat and high-protein diets increase susceptibility to endogenous malodorous gas compounds (EMGCs), particularly in long-term enclosed environments with limited nutrients. Auricularia auricula polysaccharides (AAP) are proposed to mitigate protein residues fermentation by gut microbiota, thereby reducing EMGCs accumulation and benefiting both health and environmental quality. This study elucidated the prebiotic mechanisms of AAP via rat interventions, fecal microbiota transplantation in pseudo-sterile rats, and in vitro fermentation with AAP-derived functional components and specific bacterial strains. Results demonstrated that AAP intervention effectively reduced EMGCs levels in feces and adipose tissue induced by high-fat and high-protein diets. The degradation products of AAP, including mannitol, lactose, and lyxose, along with reshaped gut microbiota, especially the functional strain Bacteroides xylanisolvens, all exhibited independent EMGCs-inhibiting activities. Mechanistically, AAP or its degradation products enhanced hepatic CYP450 expression through bile acid-mediated enterohepatic circulation, forming a gut-liver axis for EMGCs suppression. Additionally, gut metabolites lactose and maltose promoted colonic carbohydrate absorption, hepatic Col5a3 and Col1a1 enhanced hepatic protein absorption. Upregulated gut metabolites (histidine, choline bitartrate, lactose, maltose) and hepatic genes (Abcg8, Abcb9) enriched the ABC transporter pathway, expediting hepatic EMGCs excretion. This study supports AAP as a dietary supplement to inhibit EMGCs, ensuring environmental livability and health. - Source: PubMed
Publication date: 2025/12/20
Zhang TingtingLiu HongYuan JingXie Beizhen