AASDH
- Known as:
- AASDH
- Catalog number:
- 000876A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- AASDH
Related genes to: AASDH
- Gene:
- AASDH NIH gene
- Name:
- aminoadipate-semialdehyde dehydrogenase
- Previous symbol:
- -
- Synonyms:
- NRPS998, LYS2, ACSF4
- Chromosome:
- 4q12
- Locus Type:
- gene with protein product
- Date approved:
- 2007-10-17
- Date modifiied:
- 2015-08-26
Related products to: AASDH
Related articles to: AASDH
- Mongolian horses, celebrated for their resilience and adaptability, undergo marked physiological transformations during sexual maturation. This study employed whole-transcriptome sequencing to conduct a comparative analysis of mRNA and circular RNA (circRNA) expression profiles, along with their interactive regulatory networks, in testicular tissues of Mongolian horses pre- and post-sexual maturity. Histological examinations using hematoxylin-eosin (H.E.) and 4’,6-diamidino-2-phenylindole (DAPI) staining revealed distinct morphological differences between sexually immature and mature testicular tissues. Employing DESeq2 analysis on the whole-transcriptome data, we identified 10,317 differentially expressed genes (5,280 upregulated, 5,033 downregulated) and 356 differentially expressed circRNAs (263 upregulated, 93 downregulated) across the two developmental stages. Real-time PCR validation is supportive of the reliability of the RNA-seq findings. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses elucidated that the differentially expressed genes predominantly contribute to reproductive development, gamete generation, and diverse signaling pathways. Additionally, annotation analysis of host genes corresponding to the differentially expressed circRNAs demonstrated congruent expression trends between selected host genes and their associated circRNAs. Notably, this study explored the regulatory network interconnecting circRNAs, microRNAs (miRNAs), and mRNAs, underscoring a critical role for circRNAs in miRNA-mediated gene expression modulation. These findings provide novel mechanistic insights into the molecular underpinnings of testicular development in stallions, using the Mongolian horse as a model. Specifically, we identified the circRNA eca_circ_0005223 and its host gene TGFBRAP1 as key regulators, with their high expression in immature testes suggesting a pivotal role in the TGF-β signaling pathway during early development. Furthermore, we validated a functional ceRNA regulatory axis comprising eca_circ_0008614, eca-miR-432, and the target gene AASDH, revealing a novel post-transcriptional mechanism governing spermatogenesis. These findings provide novel mechanistic insights into the molecular underpinnings of testicular development in Mongolian horses and establish a foundational framework for future investigations into the specific functions of these genes and circRNAs within the context of whole-transcriptome dynamics. - Source: PubMed
Publication date: 2026/04/28
Du MingLiu YuanyiHe QianqianZhang XinzhuangZhao YipingLi BeiBai DongyiBou GerelchimegBao TugeqinWen XinDugarjaviin Manglai - In recent years, liquid-liquid phase separation (LLPS) has garnered increasing attention in the field of oncology. However, its role in osteosarcoma remains largely unexplored. We aimed to construct a prognostic risk model associated with LLPS and to investigate the impact of LLPS-related genes on osteosarcoma briefly. - Source: PubMed
Publication date: 2025/12/29
Huang XinyuXiong LiangZeng JiaxingLi ShanhangCai YangjieZou ZhuanYang MingxiuLi HeningLiu YunHe Maolin - The enzyme 2-aminoadipic-6-semialdehyde dehydrogenase () plays a crucial role in metabolic pathways and has emerged as a significant player in multiple pathological conditions, including cancer and cardiomyopathies. has been implicated in colorectal cancer (CRC), particularly in microsatellite instability (MSI)-high tumors, in which genetic alterations may contribute to chemotherapy resistance and tumor progression. In addition to CRC, dysregulation of has been observed in hepatocellular carcinoma (HCC) and lung adenocarcinoma (LUAD), where it influences lipid metabolism and oncogenic pathways. Additionally, emerging evidence suggests a strong link between and cardiomyopathies, highlighting its potential as a biomarker of ischemic cardiomyopathy-induced heart failure. At the molecular level, functions in ATP binding and acid-thiol ligase activity, and plays a pivotal role in stress responses, lysine metabolism, and oxidative stress protection. Its association with metabolic reprogramming and the tumor microenvironment suggests that targeting could enhance current therapeutic strategies for cancer and cardiovascular diseases. This review comprehensively explores the diverse roles of , emphasizing its potential as a prognostic biomarker and therapeutic target for multiple diseases. A deeper understanding of may pave the way for novel treatment strategies that integrate metabolic modulation with conventional therapies and improve clinical outcomes in both oncology and cardiology. - Source: PubMed
Jaradat Jaber HJalali PooyaAmro RaghadAlsalhi Hamza KSerag IbrahimAl-Nusairi Ahmed MSaeed Anwaar - The resistance risk and mechanisms of cyclobutrifluram in are unclear. The baseline sensitivity of 111 isolates to cyclobutrifluram was 0.10 ± 0.07 μg/mL. Eight cyclobutrifluram-resistant mutants of were generated in the laboratory, exhibiting high-level and relative stable resistance. Cross-resistance was found between cyclobutrifluram and boscalid or pydiflumetofen, yet no cross-resistance was observed between cyclobutrifluram and iprodione, azoxystrobin, mefentrifluconazole, or difenoconazole. Each resistant mutant exhibited a reduced compound fitness index (CFI) compared to their parental isolates. An S73L substitution in AaSdhC or a P113T, H134N, or D145N mutation in AaSdhD conferred cyclobutrifluram resistance. Allele-specific PCR (AS-PCR) methods for the detection of mutations AaSdhC, AaSdhD, AaSdhD, and AaSdhD were successfully developed. In summary, exhibits a moderate risk for developing resistance to cyclobutrifluram, attributed to the S73L substitution in AaSdhC or the P113T, H134N, or D145N mutations in AaSdhD, which are detectable using specific AS-PCR methods. - Source: PubMed
Publication date: 2025/02/10
Peng QinTang LijunTang ShiqiWang ShuaiMiao JianqiangLiu Xili - Ischemic cardiomyopathy (ICM) induced heart failure (HF) is one of the most common causes of death worldwide. This study aimed to find candidate genes for ICM-HF and to identify relevant biomarkers by machine learning (ML). - Source: PubMed
Publication date: 2023/03/17
Kong XiangJinSun HouRongWei KaiMingMeng LingWeiLv XinLiu ChuanZhenLin FuShunGu XingHua