A2ML1
- Known as:
- A2ML1
- Catalog number:
- 000855A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- A2ML1
Related genes to: A2ML1
- Gene:
- A2ML1 NIH gene
- Name:
- alpha-2-macroglobulin like 1
- Previous symbol:
- CPAMD9
- Synonyms:
- FLJ25179, p170
- Chromosome:
- 12p13.31
- Locus Type:
- gene with protein product
- Date approved:
- 2005-07-20
- Date modifiied:
- 2018-04-17
Related products to: A2ML1
Related articles to: A2ML1
- Pancreatic ductal adenocarcinoma (PDAC) has two principal molecular subtypes-classical and basal-like-with divergent prognosis and chemotherapy response, yet transcriptomic classifiers rarely generalize across cohorts or quantify per-patient uncertainty. We trained a classical-versus-basal-like classifier on CPTAC-PDAC ( = 140) and externally validated it on histology-filtered TCGA-PAAD ( = 150). Twelve algorithms were benchmarked under stratified nested cross-validation with four-method consensus feature selection; domain adaptation (naive transfer, CORAL, and ComBat), four conformal procedures (split, weighted, CV+, and Conformal Risk Control), and a four-method consensus explainable-AI framework (SHAP, LIME, permutation importance, and decision-curve ablation) with pathway enrichment were then evaluated. Top models reached a cross-validated AUROC ≈ 0.96 and external AUROC 0.913-0.938 (top-3 ensemble 0.961); batch correction did not improve transfer, indicating minimal residual batch effect. Consensus explainability recovered keratinization biology and nominated five candidate genes (GSDMC, A2ML1, PIP5K1B, IL20RB, and AKR7L) beyond the Moffitt signature. All four conformal procedures plateaued near 0.85 coverage at α = 0.05 under zero-shot transfer, whereas local recalibration on a small target sample restored nominal coverage. We present a transparent, externally validated, uncertainty-aware and TRIPOD+AI-compliant PDAC subtype classifier, best deployed as a calibrated decision-support tool with site-specific recalibration. - Source: PubMed
Publication date: 2026/08/04
Yasar SeymaYagin Fatma HilalAlzakari Sarah AAlkhalifa Amal KAl-Hashem FahaidTabnjh Abedelmalek Kalefh - Regulated necrosis, a type of programmed cell death, is a major factor in cancer development. The function of regulated necrosis-related genes (RNRGs) in pancreatic cancer (PC) remains unclear. This study aimed to determine the heterogeneity associated with RNRGs in PC. - Source: PubMed
Publication date: 2026/06/04
Feng LeiZhang JianminZhu Zhonghui - Psoriasis is a chronic, immune-mediated disorder with an unmet need for effective treatments. To systematically prioritize therapeutic targets, we integrated proteome-wide Mendelian randomization (MR) with expression validation in blood/skin, genetic susceptibility analysis, differential gene expression (DGE) from bulk and single-cell RNA sequencing (scRNA-seq), colocalization, pathway enrichment, and protein-protein interaction analyses. - Source: PubMed
Si ShuchengWang XiaoxiaoZhan Siyan - Thioester-containing proteins (TEPs) play vital roles in the innate immune responses to biotic and abiotic stresses. However, comprehensive genome-wide identification and expression analyses of the TEP gene family in Micropterus salmoides (M. salmoides) are lacking. In this study, 21 TEP genes were identified in the genome of M. salmoides, including 7 copies in A2M, two in CD109, five in C3, four in C4, and single copies of C5, A2ML1, and CPAMD8. Functional analyses and evolutionary relationships indicated a high level of homology with other teleost TEPs. Transcript sequence variants analysis identified numerous non-synonymous single nucleotide variants (nsSNVs) in TEP gene transcripts, with MsA2ML1, MsC3, and MsC4 being among the most affected. These variants, while potentially reflecting genomic diversity, require further validation to distinguish true polymorphisms from transcriptional or technical artifacts. Alternative splicing (AS) analysis has revealed multiple splicing sites and events in the TEPs of M. salmoides. Differential alternative splicing (DAS) analysis showed a significant induction of MsA2ML1 variants after infection with Aeromonas. Analysis of the gene structure and multiple sequence alignments revealed that these variants were produced through AS of the 18th exon. Both transcriptome quantification and qRT-PCR validation confirmed TEP gene responsiveness to Aeromonas infection in M. salmoides. Our study provides the first comprehensive characterization of the TEPs repertoire in largemouth bass, and reveals infection-induced AS as a novel layer of regulatory complexity in teleost innate immunity. - Source: PubMed
Publication date: 2026/02/26
Chen YupingJiang MengzhenTang ShengmeiXian YalingWen JiayiZou ZechengWang Yongsheng - This study aimed to elucidate the mechanistic role of M2 tumor-associated macrophages in esophageal cancer (EC) progression and to construct an M2 macrophage-related gene signature for prognostic prediction. - Source: PubMed
Publication date: 2026/02/02
Wei GuangxiaYe ChunlinHuang YunheLuo ZanXu BinLi Junyu