PKCβ II (dn)
- Known as:
- PKCβ II (dn)
- Catalog number:
- 000591A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- PKCβ ()
Related genes to: PKCβ II (dn)
- Gene:
- FKBP1A NIH gene
- Name:
- FKBP prolyl isomerase 1A
- Previous symbol:
- FKBP1
- Synonyms:
- FKBP-12, FKBP12, PKC12, PPIASE, FKBP12C
- Chromosome:
- 20p13
- Locus Type:
- gene with protein product
- Date approved:
- 1992-09-14
- Date modifiied:
- 2018-11-01
- Gene:
- HINT1 NIH gene
- Name:
- histidine triad nucleotide binding protein 1
- Previous symbol:
- PRKCNH1, HINT
- Synonyms:
- PKCI-1
- Chromosome:
- 5q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 1996-05-15
- Date modifiied:
- 2016-10-05
- Gene:
- MARCKS NIH gene
- Name:
- myristoylated alanine rich protein kinase C substrate
- Previous symbol:
- MACS
- Synonyms:
- PKCSL, 80K-L
- Chromosome:
- 6q21
- Locus Type:
- gene with protein product
- Date approved:
- 1990-01-05
- Date modifiied:
- 2016-06-03
- Gene:
- NME3 NIH gene
- Name:
- NME/NM23 nucleoside diphosphate kinase 3
- Previous symbol:
- -
- Synonyms:
- DR-nm23, NM23-H3, NDPKC
- Chromosome:
- 16p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1996-12-19
- Date modifiied:
- 2016-10-05
- Gene:
- PRKCA NIH gene
- Name:
- protein kinase C alpha
- Previous symbol:
- PKCA
- Synonyms:
- PKCα
- Chromosome:
- 17q24.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-02
- Date modifiied:
- 2018-07-11
Related products to: PKCβ II (dn)
17 kDa PKC-potentiated inhibitory protein of PP1,Cpi,Cpi17,CPI-17,Ppp1r14a,Protein kinase C-potentiated inhibitor protein of 17 kDa,Protein phosphatase 1 regulatory subunit 14A,Rat,Rattus norvegicus17 kDa PKC-potentiated inhibitory protein of PP1,CPI17,CPI-17,Homo sapiens,Human,PPP1INL,PPP1R14A,Protein kinase C-potentiated inhibitor protein of 17 kDa,Protein phosphatase 1 regulatory subunit 14A17 kDa PKC-potentiated inhibitory protein of PP1,Cpi17,CPI-17,Mouse,Mus musculus,Ppp1r14a,Protein kinase C-potentiated inhibitor protein of 17 kDa,Protein phosphatase 1 regulatory subunit 14A17 kDa PKC-potentiated inhibitory protein of PP1,CPI17,CPI-17,Pig,Protein kinase C-potentiated inhibitor protein of 17 kDa,Protein phosphatase 1 regulatory subunit 14A,Sus scrofaActive PKC ιActive PKC betaIIActive PKC bIIActive PKC bII5 ugActive PKC deltaActive PKC deltaActive PKC deltaActive PKC delta5 ugActive PKC etaActive PKC gammaActive PKC gamma Related articles to: PKCβ II (dn)
- Polycystic ovary syndrome (PCOS) is a prevalent reproductive endocrine disorder in women. While the role of androgens in PCOS is well-recognized, the underlying mechanisms warrant further investigation. In this study, we identified potential hub androgen-related genes (ARGs) in PCOS and established diagnostic and classification models to find novel biomarkers for PCOS therapy. Five datasets (GSE34526, GSE80432, GSE95728, GSE124226, and GSE137684) were retrieved from GEO, followed by data normalization and batch effect removal. To identify hub genes, a PPI network was constructed based on differentially expressed ARGs. Subsequently, we employed the least absolute shrinkage and selection operator (LASSO) regression analysis and random forest (RF) algorithm to screen hub ARGs. Besides, hub ARGs associated with PCOS were determined by integrating the results of the three algorithms. Additionally, a nomogram was constructed using these hub ARGs to predict the risk of PCOS development. We also investigated the classification of ARG molecular subtypes and assessed immune characteristics and gene expression profiles in different subtypes. Lastly, RT-qPCR was utilized to validate the reliability of the hub genes. A total of 91 ARGs were retrieved from the GSEA website. This study included 26 healthy and 34 PCOS samples. Using the LASSO identified 13 key ARGs, RF identified 10 crucial ARGs, and PPI identified 19 pivotal ARGs. Integration of three methods identified four hub ARGs (, and ). And a nomogram was constructed to predict the risk of PCOS occurrence. Notably, we validated the expression levels of the 4 hub ARGs in ovarian tissues from PCOS mice using RT-qPCR. The results showed that the expression levels of , and were significantly downregulated, while was significantly upregulated, which was consistent with our data analysis findings. Furthermore, samples were divided into two distinct ARG patterns and further explored the relationship between immune cell infiltration and these patterns. ARG scores were significantly higher in cluster A or gene cluster A compared to cluster B or gene cluster B. Finally, we evaluated the expression levels of PCOS-related genes in distinct clusters. In summary, our results may further elucidate the mechanisms of PCOS pathogenesis and offer novel ideas for PCOS diagnosis and treatment. - Source: PubMed
Publication date: 2026/03/19
He XinlingSu LanYin JiLai YuanyuanYang HanYu ZhengZheng XiaoyanLiu JiaYang Jie - Prostate cancer (PCa) is a major malignant tumor that significantly threatens male health, in which various immune pathways are critically involved in its pathogenesis. This study aims to elucidate the immunomodulatory mechanisms of active constituents from 11 traditional Chinese medicines in PCa. - Source: PubMed
Publication date: 2026/03/12
Chen QiDong LiangXue Wei - Acute myeloid leukemia (AML) remains the most aggressive form of leukemia, underscoring the urgent need for novel treatment strategies. Drug repurposing offers a promising approach to accelerate drug development process. Cardiac glycosides (CGs), traditionally used for heart conditions, have shown potential for AML therapy. As leukemic stem cells (LSCs) are key contributors to AML relapse and chemotherapy resistance, this study aims to elucidate the potential shared mechanisms of proscillaridin (PSN) and ouabain (OUA), two CGs with anti-LSC activity, focusing on their multitarget effects-an emerging strategy in cancer therapy. - Source: PubMed
Publication date: 2026/02/07
Samart ParinyaPoohadsuan JiraratChanthateyanonth SupasornIssaragrisil SurapolLuanpitpong Sudjit - Mitochondrial permeability transition-driven necrosis (MPTDN) has been implicated in a variety of diseases, but its relationship with colorectal cancer (CRC) prognosis is unclear. - Source: PubMed
Publication date: 2026/03/09
Huang ChenXinXie DiYaLin BinShengZhang Kun - Shenzhu granules (SG) are composed of five traditional Chinese herbal medicines, all of which are frequently used in different kinds of functional foods. This study systematically evaluates the anti-fatigue effects of SG and explores the underlying mechanisms to support its potential as a functional food. The anti-fatigue effects of SG were assessed through a functional anti-fatigue test and measurement of serum oxidative stress markers. Additionally, multi-omics approaches, including metabolomics, transcriptomics, and proteomics were used to investigate the mechanisms underlying the anti-fatigue effects of SG. - Source: PubMed
Publication date: 2026/03/23
Zhang HongmingLi XingxingLi MengGuo WenjunZhang ManqiGao XiaohanLiu JiaxinLin YanlingXie ShengxuZhang DianwenLiu YueXu Yajuan