APPL1
- Known as:
- APPL1
- Catalog number:
- 000524A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- APPL1
Related genes to: APPL1
- Gene:
- APPL1 NIH gene
- Name:
- adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
- Previous symbol:
- -
- Synonyms:
- APPL
- Chromosome:
- 3p14.3
- Locus Type:
- gene with protein product
- Date approved:
- 2007-01-26
- Date modifiied:
- 2016-03-14
Related products to: APPL1
Adapter protein containing PH domain, PTB domain and leucine zipper motif 1,APPL,APPL1,DCC-interacting protein 13-alpha,DIP13A,Dip13-alpha,Homo sapiens,Human,KIAA1428Adapter protein containing PH domain, PTB domain and leucine zipper motif 1,Appl1,DCC-interacting protein 13-alpha,Dip13a,Dip13-alpha,Kiaa1428,Mouse,Mus musculusanti-APPL1anti-APPL1anti-APPL1anti-APPL1 / APPL (aa111-160)anti-APPL1 type: Primary antibodies host: RabbitAnti-Mouse APPL1 (KIAA1428), Rabbit PolyclonalAnti-Mouse APPL1 (KIAA1428), Rabbit PolyclonalAntibodies: APPL1 HOST: Goat Clonality: pAbAPP Gene amyloid beta (A4) precursor proteinAPPL1 DIP13A antibody Ab host: GoatAPPL1 DIP13A (C-term) antibody Ab host: GoatAPPL1 DIP13A IgG antibody Ab host: RabbitAPPL1 Antibody Related articles to: APPL1
- Necroptosis is implicated in the pathogenesis of various inflammatory diseases, including periodontitis. This study aimed to investigate the molecular mechanisms underlying necroptosis in gingival fibroblasts (GFs) and to evaluate the therapeutic potential of AdipoAI, a novel adiponectin receptor agonist, administered locally, along with its regulatory effect on necroptosis. - Source: PubMed
Publication date: 2026/07/27
Qiu WeiDing DianShao JunHuang YuxuanChen ZehaoGuo RuimingZhao HuaxuanWu HongleFang Fuchun - Gastrointestinal (GI) involvement in systemic sclerosis (SSc) affects up to 90% of patients and is a major driver of morbidity and mortality. Despite its clinical importance, GI disease in SSc is highly heterogeneous, with upper and lower GI manifestations representing distinct phenotypic extremes whose underlying immunologic basis remains poorly defined. - Source: PubMed
Publication date: 2026/05/21
McMahan Zsuzsanna HPuttapaka SrinivasHulett TylerShah Ami AFaheem KathrynHu ShaohuiSonmez GamzeRamos PedroKulkarni Subhash - Here we investigate the status of the adiponectin-PEPITEM pathway in early, treatment naive rheumatoid arthritis (RA) and psoriatic arthritis (PsA) and the therapeutic efficacy of PEPITEM administration in preclinical models. - Source: PubMed
Publication date: 2026/04/13
Wahid MussaratKemble SamuelAbudu OladimejiSaviano AnellaMahony ChristopherLewis Jonathan WNicholson Thomas ASchettino AnnaMarigliano NoemiFrost KathrynBegum JenefaUrbanowski Alyssa MLimo MarionJha RakeshJarquin Sandra MartinezPezhman LalehDegan Abbie E AAnderson Amy ESmith Charlotte GBatki ArmaitiAdams HollyCaso FrancescoScarpa RaffaeleMcInnes IainSiebert StefanPratt Arthur GFiler AndrewRaza KarimCroft Adam PChimen Myriamde Cogan FelicityRainger G EdIqbal Asif JMaione FrancescoMcGettrick Helen M - - Source: PubMed
Cellular Longevity Oxidative Medicine And - Adiponectin and irisin regulate energy homeostasis and interact with peroxisome proliferator-activated receptor coactivator 1α (PGC-1α). However, whether they establish a signal connection via PGC-1α is unclear. In the current study, the expression of irisin was significantly decreased in the skeletal muscle of adiponectin knockout (KO) mice, accompanied by a de crease in APPL1/p38 mitogen-activated protein kinase (MAPK)/PGC-1α. However, adiponectin administration reversed this effect. In vitro, the p38 MAPK/PGC-1α signalling pathway mediated adiponectin-induced FNDC5 expression and irisin release in mouse-derived C2C12 myotube cells. Moreover, obesity caused dysregulation of the adiponectin/APPL1/p38 MAPK/PGC-1α signalling pathway in murine skeletal muscle, ultimately inhibiting irisin synthesis and secretion; meanwhile, prolonged exercise or exogenous recombinant adiponectin intervention activated this pathway in mouse skeletal muscle. This corresponded with an apparent improvement in high-fat diet-induced insulin resistance. The effect of mechanically stretching C2C12 myotube cells was consistent with in vivo findings. Hence, adiponectin upregulates irisin through the APPL1/p38MAPK/PGC-1α signalling pathway in murine skeletal muscle, which may enhance insulin sensitivity. - Source: PubMed
Publication date: 2026/02/05
Huang RuiqiXu SitongGuo QiCao ShichengTang DonghuiYi Xuejie