STAT3
- Known as:
- STAT3
- Catalog number:
- 000480A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- STAT3
Related genes to: STAT3
- Gene:
- STAT3 NIH gene
- Name:
- signal transducer and activator of transcription 3
- Previous symbol:
- -
- Synonyms:
- APRF
- Chromosome:
- 17q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1995-11-08
- Date modifiied:
- 2019-04-23
Related products to: STAT3
Acpin1,Acrosomal protein ACPIN1,Mouse,Mus musculus,Sipar,STAT3-interacting protein as a repressorAnserine Signal Transducer And Activator Of Transcription 3 Elisa Kit (STAT3)Anserine anti - Signal Transducer And Activator Of Transcription 3 Elisa Kit (STAT3)Anti- STAT3 (Ab-705) AntibodyAnti- STAT3 (Ab-705) AntibodyAnti- STAT3 (Ab-727) AntibodyAnti- STAT3 (Ab-727) AntibodyAnti- STAT3 (Phospho-Ser727) AntibodyAnti- STAT3 (Phospho-Ser727) AntibodyAnti- STAT3 (Phospho-Tyr705) AntibodyAnti- STAT3 (Phospho-Tyr705) AntibodyAnti-Human STAT3, Rabbit PolyclonalAnti-Human STAT3, Rabbit Polyclonal affinity purified IgGanti-n STAT3 , Rabbit polyclonal to n STAT3 , Isotype IgG, Host RabbitAnti-phospho-STAT3 (pTyr705<_SUP>) produced in rabbit Antibody Related articles to: STAT3
- TB (Tuberculosis) and HIV co-infection remains a major global health challenge, with limited understanding of how these pathogens impact local immune responses in the lungs. This study is the first to investigate the modulation of IL-21 during LTBI and Mycobacterium tuberculosis (Mtb)/ Simian Immunodeficiency Virus (SIV) co-infection in non-human primates (NHP). We show that IL-21 expression, predominantly derived from CD4⁺ T cells, is significantly reduced in lungs of Mtb/SIV co-infected macaques, especially in the absence of cART. Although cART and cART with 3HP partially restore IL-21-producing CD4⁺ T cells, levels remain below those in LTBI, indicating ongoing immune impairment. Spatial transcriptomic analysis suggests localized alterations in immune signaling, including differences in STAT1- and STAT3-associated transcriptional profiles and reduced Mtb-specific IFN-γ responses in co-infected animals. Together, our findings indicate that IL-21-producing CD4⁺ T cells are selectively and persistently impaired in the lungs during Mtb/SIV co-infection despite antimicrobial and antiviral therapy. These results highlight a compartment-specific deficit in immune reconstitution and suggest that IL-21-associated pathways may warrant further investigation as potential targets for host-directed therapeutic strategies. - Source: PubMed
Publication date: 2026/05/05
Shivanna VinayEscalona Renee DChuba ColinSingh Shashi PrakashMoustafa Ahmed ABrown J QuincyXiao ChenyaoKim SangkyuDick Edward JMehra SmritiPaiardini MirkoSharan Riti - Gastrointestinal symptoms in Parkinson's disease (PD), in particular chronic constipation, are common and are treated in China using the traditional Chinese medicine (Jia-Wei-Ji-Chuan-Jian decoction) (JWJCJ)). However, information on therapeutic targets and the underlying mechanism is limited. - Source: PubMed
Publication date: 2026/05/05
Loong Shi KayWu FeifeiLiu YizhouVoratunyakit NapattharinWei ShangyuLi WeiLi RuiPan Weidong - Cervical cancer remains a major global health challenge, where dysregulated JAK2 signaling constitutes a key molecular driver. Nevertheless, selective small-molecule JAK2 inhibitors for HPV-positive cervical cancer are still limited. Here, we integrated biochemical assays, QSAR-machine learning, and molecular dynamics simulations to identify potent JAK2 inhibitors. A series of naphthalene-based derivatives, including hydroxynaphthalenamide and phosphorylated dihydronaphthylamide analogs, were evaluated for cytotoxicity in HeLa cells and JAK2 kinase inhibition. Several compounds exhibited selective cytotoxicity with minimal activity toward normal fibroblasts, among which and showed low-nanomolar JAK2 inhibition and strong apoptosis induction through suppression of the JAK2/STAT3/STAT5 pro-tumorigenic signaling pathway. To accelerate hit identification, a QSAR-machine learning (QSAR-ML) framework was employed to prioritize 13 newly designed derivatives. Among three ensemble boosting models, the Categorical Boosting (CB) model demonstrated the strongest predictive capability, achieving a high R of 0.955 for the training set and a low RMSE of 0.156 for the test set. This model successfully identified five active candidates with strong prediction-experiment agreement (MAPE = 2.6-14.4%), with and meeting drug-likeness criteria and displaying potent nanomolar JAK2 inhibition. Finally, 1-μs molecular dynamics simulations revealed that hydrophobic contacts and hydrogen bonding cooperatively stabilize these inhibitors within the JAK2 ATP-binding pocket. Collectively, these findings establish a QSAR-ML-guided strategy for accelerating JAK2 inhibitor discovery and highlight naphthalene-based scaffolds as promising leads for targeted cervical cancer therapy. - Source: PubMed
Publication date: 2026/05/05
Todsaporn DuangjaiSanachai KamonpanSuddee NattanitKanjanapanyakom ChompunudMaitarad PhornphimonWorayuthakarn RattanaAonbangkhen ChanatThasana NoppornRungrotmongkol Thanyada - Small cell lung cancer (SCLC) is a highly aggressive malignancy. This study investigated whether Apatinib (Apa) combined with Adebrelimab (Ade) exerted synergistic effects against SCLC. - Source: PubMed
Publication date: 2026/04/30
Zhu YipingCheng XiangweiWu LinfengWang YifanHuang Laiquan - Pterostilbene is a polyphenolic compound with antioxidant and anti-inflammatory properties. This study aims to explore its potential therapeutic effects on Abdominal Aortic Aneurysm (AAA). - Source: PubMed
Publication date: 2026/04/29
Li WeiqiXiao XiaoyongYang JingLiu DehongSun Zhanpeng