SMAD3
- Known as:
- SMAD3
- Catalog number:
- 000474A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- SMAD3
Related genes to: SMAD3
- Gene:
- SMAD3 NIH gene
- Name:
- SMAD family member 3
- Previous symbol:
- MADH3
- Synonyms:
- JV15-2, HsT17436
- Chromosome:
- 15q22.33
- Locus Type:
- gene with protein product
- Date approved:
- 1996-11-15
- Date modifiied:
- 2016-10-05
Related products to: SMAD3
Related articles to: SMAD3
- Pathological cardiac fibrosis arising from acute/chronic myocardial injury drives ventricular remodeling, functional impairment, and elevated mortality through mechanisms lacking effective therapies. Central to fibrogenesis, myofibroblast activation via TGFβ1-Smad3 signaling necessitates targeted therapeutic strategies. - Source: PubMed
Publication date: 2026/04/18
Chen ChengLu WenyuanPan QiCui ChuanjueZhang YuzeWang HaoyuHan JianingYuan ShengLin ZhangyuXie YingyiDou KefeiHou Jianfeng - Renal interstitial fibrosis (RIF), driven by persistent TGF-β signaling, is a hallmark of progressive kidney disease. Because deubiquitinases (DUBs) like USP4 stabilize TGF-β type I receptor (TβRI) to prolong signaling, targeting USP4 represents a promising antifibrotic strategy. - Source: PubMed
Publication date: 2026/04/03
Fan JianhuiLiu YuqiZhan ShihongLing HuayuYan JiaminXie LeyiWang WeiguangXiao XiaoLi Ao - To diagnose undiagnosed Heritable Thoracic Aortic Disease (HTAD) using targeted Next-Generation Sequencing (NGS) technology on human aorta tissue obtained from a single-center biobank. - Source: PubMed
Publication date: 2026/04/17
Lee HaKim YoonjungKim Myeong SuLee Kyung-ASong Suk-Won - Steroid-induced osteonecrosis of the femoral head (SONFH) is a debilitating disease caused by glucocorticoid abuse, characterized by complex pathogenesis and unclear molecular mechanisms. Dysfunction of bone marrow mesenchymal stem cells (BMSCs) and their exosome-mediated signalling is a key contributor to SONFH, although the precise mechanisms remain to be elucidated. In this study, the differential expression profiles of long noncoding RNAs (lncRNAs), microRNAs (miRNAs) and messenger RNAs (mRNAs) in exosomes derived from human BMSCs (hBMSCs) obtained from patients with SONFH compared to controls with femoral neck fractures were identified. Through next-generation sequencing, a novel lncRNA, LNC000133, associated with SONFH was discovered. Using Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis and competing endogenous RNA (ceRNA) network construction, the LNC000133/miR-362-5p/TGF-β3/SMAD3/BMP2 signalling axis was established. The definitive expression, localization and full-length sequence of LNC000133 in BMSCs were subsequently validated by Northern blot, quantitative real-time polymerase chain reaction (qRT-PCR), fluorescence in situ hybridization (FISH) and rapid amplification of cDNA ends (RACE). Most notably, mechanistic studies demonstrated that LNC000133-modified BMSCs-derived exosomes were efficiently taken up by osteoblasts, which promoted proliferation and osteogenic differentiation by targeting the miR-362-5p/TGF-β3/SMAD3/BMP2 signalling pathway. - Source: PubMed
Yang ChengbinXia TixiongLi XiChen TongXu Yingxing - The transforming growth factor-β (TGF-β) pathway is a master regulator of epithelial-mesenchymal transition (EMT) in retinal pigment epithelial (RPE) cells, a key process in fibrotic ocular diseases. However, key modulators fine-tuning this pathway in RPE are incompletely characterized. This study investigates the role of the receptor tyrosine kinase RET in TGF-β1-induced RPE-EMT. - Source: PubMed
Publication date: 2026/04/15
Chen MeilanZhao RuiChen XiaohuiXu LuHu Chun