SIRT2
- Known as:
- SIRT2
- Catalog number:
- 000468A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- SIRT2
Related genes to: SIRT2
- Gene:
- SIRT2 NIH gene
- Name:
- sirtuin 2
- Previous symbol:
- SIR2L
- Synonyms:
- -
- Chromosome:
- 19q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1998-10-14
- Date modifiied:
- 2016-10-05
Related products to: SIRT2
Related articles to: SIRT2
- Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, characterized by an extremely low survival rate once diagnosed. Over 90% of cases harbor activating mutations, which are associated with metabolic reprogramming and altered endocytic activity. New treatment modalities are urgently needed. Phospholipid-shelled, gas-filled nanobubbles (NBs) are promising ultrasound (US) contrast agents and drug delivery vehicles, with potential applications in pancreatic cancer. However, their mechanisms of cellular internalization and the resulting biological responses need to be better understood before they can be effectively utilized as theranostic agents. Here, we analyzed the internalization kinetics, endocytic pathways, acoustic responses, and cell-stress-related protein expression in perfluorocarbon-filled NBs in two pancreatic cancer cell lines: KRAS-mutant PANC-1 and KRAS wild-type BxPC-3 cells showed distinct NB uptake profiles. Flow cytometry demonstrated approximately 1.5-fold higher TR-NB uptake in PANC-1 cells compared with BxPC-3 cells, suggesting enhanced cellular association and/or intracellular retention. Higher NB signal in PANC-1 cells was accompanied by weaker and less punctate LysoTracker staining, whereas BxPC-3 cells displayed brighter, more granular acidic vesicles, suggesting differences in intracellular trafficking and compartmentalization. Pharmacological inhibition of endocytosis revealed that clathrin-mediated endocytosis contributes predominantly to uptake in BxPC-3, whereas macropinocytosis appears to play a greater role in PANC-1 cells. Upon US exposure, NBs exhibited strong initial acoustic activity that declined over time. Analysis of stress-response-associated protein expression revealed cell-specific differences: PANC-1 cells exhibited higher levels of FABP-1, HSP60, SOD2, Thioredoxin-1, and SIRT2, whereas BxPC-3 cells displayed increased COX-2 and PON-2. Collectively, our findings demonstrate that NB internalization and fate differ between PDAC subtypes, potentially reflecting cell type dependent variations in endocytic, lysosomal and adaptive pathways, underscoring the importance of developing cell-tailored nanocarrier designs to enhance delivery precision and therapeutic efficacy. - Source: PubMed
Publication date: 2026/09/07
Appak-Baskoy SilaKhan Muhammad SaadPatel DhruviLodyga MonikaExner Agata AKolios Michael CCoe Imogen R - Intervertebral disc degeneration (IDD) is a primary cause of low back pain, closely associated with the senescence of nucleus pulposus cells (NPCs). Energy metabolism disorders and lactate accumulation are observed in degenerated intervertebral discs. However, the molecular mechanism through which lactate accumulation induces IDD and its upstream regulatory factors remain unclear. - Source: PubMed
Zhang WenshengMo LingGuo HaiweiZhang XibingTang HanwuLi WenchaoLiu Caijun - A pig's ability to convert consumed feed into saleable meat is an important component of production efficiency in the swine industry. Given the polygenic and environmentally influenced nature of feed efficiency and body composition traits, conventional selection approaches have limited ability to pinpoint causal genetic factors driving variation. In this study, we performed a single-step genome-wide association study, with whole-genome sequence data (imputed from 50 to 60K SNP arrays), for feed efficiency and body composition traits using a multi-generational crossbred swine population. Overall, the three-generation pedigree consisted of 14,242 pigs, of which 9,336 pigs were phenotyped and 7,339 were genotyped. Whole-genome sequence variants were clustered into 705,923 linkage disequilibrium (LD) blocks, ranging from 0.001 to 9981.80 kb in size. A total of 133 LD blocks were significantly associated with the studied traits, several with potentially large pleiotropic effects. A total of 453 candidate genes were identified in the genomic regions of significant LD blocks. Four functional candidate genes (SIRT2, RYR1, MC4R, and LEPR) were found to harbor moderate to high impact variants, expected to affect protein function. - Source: PubMed
Publication date: 2026/09/29
Keel B NBradford H LOliver W TLindholm-Perry A KRohrer G A - Lung adenocarcinoma (LUAD) is a highly aggressive malignancy originating from the bronchial epithelium or glandular tissues and represents the most rapidly increasing subtype of lung cancer worldwide. Its high incidence and mortality rates contribute to an overall unfavorable prognosis. Therapeutic options for patients with advanced-stage LUAD remain limited, emphasizing the urgent importance of identifying reliable prognostic biomarkers and novel therapeutic targets. Silent information regulator 2 (SIRT2), a member of the mammalian sirtuin family, has been implicated in multiple cancer types; however, its functional relevance in LUAD has not yet been comprehensively defined. - Source: PubMed
Publication date: 2026/09/11
Zhang WeiRen Li-ShaBai HuanMu Ying-YingQian YueChen Hongyu - Berberine (BBR), a natural isoquinoline alkaloid, has been shown to specifically bind to sirtuin 2 (SIRT2) and exhibit anticancer activity. This study aimed to elucidate the therapeutic mechanisms of BBR in non-small cell lung cancer (NSCLC). - Source: PubMed
Publication date: 2026/09/25
Wu MingliangYang GuobiaoYang JianyeXu Mengmin