RARa
- Known as:
- RARa
- Catalog number:
- 000463A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- RARa
Related genes to: RARa
- Gene:
- RARA NIH gene
- Name:
- retinoic acid receptor alpha
- Previous symbol:
- -
- Synonyms:
- RAR, NR1B1
- Chromosome:
- 17q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1988-06-09
- Date modifiied:
- 2019-04-23
Related products to: RARa
Related articles to: RARa
- Aging drives metabolic decline and the accumulation of senescent cells that evade immune clearance. The mechanisms linking host-microbiome co-metabolism to peripheral tissue deterioration remain unclear. We hypothesized that age-dysregulated enterohepatic bile acid (BA) signaling directly promotes systemic aging and immune senescence. - Source: PubMed
Publication date: 2026/07/28
Tan JinzhuoXiong WenyanFeng YingnaLi XingjieJiang HongyuZhang Zongde - Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia characterized by the PML-RARA fusion gene and a high risk of coagulopathy. Type 2 diabetes mellitus (T2DM) is increasingly diagnosed in children and adolescents. To our knowledge, the concomitant diagnosis of these two conditions in the pediatric population has not been previously reported. We report the case of a 10-year-old girl presenting with fatigue, abdominal pain, and fever. Laboratory investigations revealed severe thrombocytopenia, leukocytosis, and 63% circulating blasts on peripheral blood smear. Bone marrow aspiration, immunophenotyping, and molecular analysis confirmed APL through detection of the t(15;17)(q24.1;q21.2) translocation and PML-RARA fusion gene. Based on a white blood cell count of 16.9 × 10⁹/L and a platelet count of 10 × 10⁹/L, the patient was classified as high-risk APL according to the Sanz classification. Severe disseminated intravascular coagulation was present at diagnosis. Concurrent metabolic evaluation demonstrated marked hyperglycemia, elevated HbA1c (8.1%), hyperinsulinemia, atherogenic dyslipidemia, and negative pancreatic autoantibodies, supporting a concomitant diagnosis of T2DM in the setting of overweight status, acanthosis nigricans, and a positive family history. Treatment was initiated according to the AML-MA 2011 induction protocol, comprising cytarabine and daunorubicin combined with all-trans retinoic acid (ATRA), intensive transfusion support, and a basal-bolus insulin regimen. At 18 months of follow-up, the patient remained in complete hematological remission under joint hematological and endocrinological surveillance. This case highlights the importance of considering metabolic disorders in children with hematologic malignancies who present with risk factors for insulin resistance. Emerging evidence suggests potential biological links between metabolic dysregulation and hematological malignancies. Early multidisciplinary management enabled successful control of both conditions and a favorable clinical outcome. - Source: PubMed
Publication date: 2026/06/28
El Hachmi IkramGhanam AyadElouali AzizaSeddik RachidRkain Maria - Lung cancer is the leading cause of cancer-related mortality worldwide, with LUAD being characterized by high incidence and mortality rates. Despite the use of various treatments, including surgery, chemotherapy, immunotherapy, and molecular targeted therapy, the prognosis in LUAD patients remains unfavorable. As a result, the diagnosis and management of LUAD still present major challenges. There is an urgent need to identify novel therapeutic targets. In this study, we analyzed to explore single-cell transcriptomic data (GSE253013 dataset) to investigate epithelial cells heterogeneity in LUAD. Tumor-specific epithelial subpopulations were identified, and the signature genes were evaluated for prognostic, diagnostic potential across several GEO datasets. Functional assays were conducted to validate the role of CRABP2 in lung cancer cells. Xenograft mouse models, rescue experiments and mechanistic analyzes involving ATRA-RAR signaling were further performed to elucidate the molecular mechanism. CRABP2 expression was positively correlated with MDK in LUAD. Functional assays demonstrated that CRABP2 promoted cell proliferation, migration, invasion, and vasculogenic mimicry through activation of the MDK/VEGF/MMP2/9/AKT signaling axis. In vivo xenograft experiments further confirmed that CRABP2 knockdown suppressed tumor growth and angiogenesis. Rescue experiments identified MDK as a critical downstream effector of CRABP2. Mechanistically, CRABP2 enhanced MDK transcription via activation of the ATRA-RAR signaling pathway and increased RARA occupancy at the MDK promoter. Clinically, elevated CRABP2 expression was associated with poor prognosis and showed strong diagnostic performance in LUAD. Collectively, our findings identify CRABP2-ATRA-RAR-MDK signaling axis that drives LUAD progression and angiogenesis. CRABP2 promotes MDK transcription through activation of RAR signaling, thereby enhancing malignant phenotypes and vasculogenic mimicry. These results establish CRABP2 as a promising diagnostic and prognostic biomarker and suggest that targeting the CRABP2-MDK axis may represent a potential therapeutic strategy for LUAD. - Source: PubMed
Publication date: 2026/07/19
Zhang JingshunZhang CuiJiang GuopengLiu XiaLi YifanWang FumanSun XuefeiSun Peidao - To evaluate the safety and effectiveness of irreversible electroporation (IRE) as salvage therapy for locally advanced pancreatic cancer (LAPC). - Source: PubMed
Publication date: 2026/07/09
Azevedo RicardoImagawa DavidRara MarianneCho HannahCho KellieValerin JenniferLee Fa-ChyiDayyani FarshidFernando DayanthaAbi-Jaoudeh Nadine - Histoplasmosis is an endemic fungal infection caused by Histoplasma species. Disseminated forms, although rare, often involve the gastrointestinal tract and primarily affect immunocompromised patients. This article presents an unusual case of gastrointestinal histoplasmosis with jejunal perforation. A 57-year-old man presented with chronic abdominal pain, intermittent fever, cough, diaphoresis, nausea, and rapid weight loss. Findings on computed tomography scans showed thickening and malignant lesions in the intestine, further evaluated through laparotomy, in addition to pulmonary involvement. Jejunal perforation and septic shock were identified and treated with antibiotics. The clinical course was unfavorable, resulting in patient's death. Peritoneal liquid cultures and hemocultures were negative, but the biopsy histological analysis revealed the presence of intracellular yeasts compatible with Histoplasma spp. This case highlights the importance of considering invasive fungal infections in apparently immunocompetent critically ill patients and reassessing diagnostic methods to ensure timely and effective treatment. - Source: PubMed
Publication date: 2026/04/28
Gaviria-Delgado Diana-MarcelaOlaya NataliaNocua-Báez Laura Cristina