SERCA1
- Known as:
- SERCA1
- Catalog number:
- 000388A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- SERCA1
Related genes to: SERCA1
- Gene:
- ATP2A1 NIH gene
- Name:
- ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
- Previous symbol:
- ATP2A
- Synonyms:
- SERCA1
- Chromosome:
- 16p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1990-09-10
- Date modifiied:
- 2016-10-05
Related products to: SERCA1
Related articles to: SERCA1
- Clinical and epidemiological evidence has suggested a potential association between kidney dysfunction and bladder cancer (BC). One hypothesis for this comorbidity is the presence of a common genetic etiology. However, little is known about the shared genetics and causality of this association. Thus, we aimed to investigate shared genetic architecture and the causal link between kidney dysfunction and bladder cancer. - Source: PubMed
Lin YifeiXiang NanyanYang YongHuang ShujunSu ShiqiFu TingtingLuo YuruiWang ZengShi RuiZheng TaoLiao BanghuaHuang Jin - Intervertebral disc degeneration is the principal pathological basis of low back pain. Currently, there are limited therapeutic strategies to regeneration intervertebral disc. - Source: PubMed
Publication date: 2026/07/04
Du YongjunLv YanLiu XiangZheng QiXu RuiTang ShaofengLiu XiongLiu FengLiang YimingMa ChengjiePeng ZhiLu Sheng - Brucellosis is a zoonotic disease caused by species. Its pathogenesis is closely associated with bacterial evasion of macrophage-mediated killing, induction of a pro-inflammatory cytokine storm, and immune-mediated pathological damage. Accumulating evidence indicates that polysaccharides (CPPS) inhibit inflammatory signaling, enhance macrophage phagocytosis, and exert immunomodulatory effects across multiple organs. However, the therapeutic potential of CPPS in brucellosis remains largely unexplored. This study aimed to investigate the effects of CPPS on the inflammatory response induced by outer membrane protein 19 (OMP19). , CPPS significantly alleviated tissue damage and simultaneously downregulated the expression of high mobility group box 1 protein (HMGB1), E-cadherin, and paxillin. , CPPS inhibited SYK/FAK/AKT phosphorylation, PKC activation, and WNT-1 signaling pathway transduction. Additionally, CPPS modulated the cytokine profile by downregulating pro-inflammatory cytokines (, ) while increasing the level of the anti-inflammatory cytokine IL-10. Furthermore, CPPS decreased the expression levels of E-cadherin and paxillin and reduced the intracellular calcium ion (Ca) concentration. was identified as a key differentially expressed gene through transcriptome sequencing. Knockdown experiments further confirmed that CPPS exerts anti-inflammatory effects by regulating . Collectively, CPPS attenuates the inflammatory response in macrophages induced by OMP19 via regulating to modulate cell adhesion and calcium signaling. - Source: PubMed
Publication date: 2026/06/02
Wang XuxuZhou ZhiyongZhang NanZhang ZiyingQi XingyueZhang XingguangGong ZhiguoZhong WuzhiLiu KunShen Yuan - The calcium ion (Ca) is a fundamental intracellular messenger involved in the transduction of diverse receptor signaling pathways. Transient increases in cytoplasmic Ca concentration ([Ca]) regulate many cellular functions, including the contraction of vascular smooth muscle cells (VSMCs), which are active components of the blood vessels. A key protein in intracellular Ca handling is the sarco/endoplasmic reticulum (SR/ER) Ca ATPase, or SERCA pump. This transmembrane protein belongs to the P-type ATPase family and uses energy from ATP hydrolysis to transport Ca from the cytoplasm into intracellular reservoirs within the SR of VSMCs. By lowering [Ca], SERCA activity promotes vasorelaxation. In mammals, three genes, ATP2A1, ATP2A2, and ATP2A3, encode at least twelve SERCA pump isoforms. Alternative mRNA splicing is the primary mechanism for generating most isoforms, leading to tissue-specific expression patterns. In VSMCs from the aorta and mesenteric arteries, the expression of SERCA2a, SERCA2b, and, more recently, SERCA3 has been reported. This chapter will review the structure, mechanism of action, and physiological role of the SERCA pump in the intracellular Ca handling of VSMCs, as well as its alterations in metabolic syndrome. - Source: PubMed
Arriero-Carrillo Cristian JRueda Angélica - Skeletal muscle is a fundamental tissue as it is found throughout the body, sustains posture, and produces movement. Yet, skeletal muscle disorders, such as myopathies, affect a large percentage of the population, degrading an individual's quality of life. A recent study links myopathy progression to the decline in chaperone-mediated autophagy that occurs during aging. Underscoring the importance of a balanced CMA pathway in maintaining skeletal muscle function and integrity, the study also provides mechanistic insights into the pathways that are dysregulated due to defective CMA and presents an approach to reverse the age-dependent decline in this process.: ATP2A1, ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1; CMA, chaperone-mediated autophagy; HSPA8, heat shock protein family A (Hsp70) member 8; LAMP2A, lysosomal associated membrane protein 2A. - Source: PubMed
Publication date: 2026/04/19
Dialynaki DimitraKlionsky Daniel J