SAA2
- Known as:
- SAA2
- Catalog number:
- 000387A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- SAA2
Related genes to: SAA2
- Gene:
- SAA2 NIH gene
- Name:
- serum amyloid A2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 11p15.1
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-12
- Date modifiied:
- 2016-10-05
Related products to: SAA2
Related articles to: SAA2
- Non-glycosylated liver-derived acute-phase amyloid A1 and A2 proteins (SAA1 and SAA2, 104 amino acids), generated by two different genes in humans (/) and other mammalian species, are considered the prime acute-phase reactants following inflammatory conditions during host defense in cells, tissues, and the circulation. While human has been identified as a pseudogene, genes in other mammalian species are coding for primarily extrahepatically expressed Saa3 proteins that also may act as suitable inflammatory markers. The discovery of SAA4 (112 amino acids, carrying an octapeptide insert) in humans and mice has paved a new avenue for the exploration of different functions of this so far unknown member of the SAA superfamily. SAA4 has originally been termed a "constitutively" expressed SAA protein, apparently due to its nature not to act as an inflammatory marker. The present overview aimed to cover possible functions-so far identified-for human SAA4 (following its expression in various diseases on mRNA and protein level) and to work out whether SAA4 might be considered-at least in part-an acute-phase protein. Alternatively, we are raising the question whether SAA4 may solely act as a bystander or even underdog within the whole SAA family, where SAA1 and SAA2 proteins (commonly termed acute-phase SAA) hold undoubtedly an eminent status during inflammatory conditions, not only as host defense reactants but also as long-lasting markers for chronic diseases and malignancies in humans. - Source: PubMed
Publication date: 2026/04/28
Malle ErnstMadreiter-Sokolowski CorinaWindpassinger Christian - Latent autoimmune diabetes in adults (LADA) shares core genetic and immunological features with type 1 diabetes (T1D) but is frequently misdiagnosed as type 2 diabetes (T2D). With few biomarkers for its timely diagnosis and management, this study integrated proteome-wide Mendelian randomisation (MR) and observational clinical analysis to identify potential LADA biomarkers. - Source: PubMed
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Yang YuanqinLu JiawenWang ZhenqianLu TianyuanDing JinWang RuofanZhou SiruiZhou ZhiguangHu Jingyi - The potential multidimensional molecular alterations during recovery of severe patients with coronavirus infectious disease (COVID-19) remain to be elucidated. Early assessment of the prognosis of severe COVID-19 may facilitate appropriate medical interventions. - Source: PubMed
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Wang QianWang DelongHu XujuanLong GangyuTang YunRen LehaoFang XiangzhiShang YouZhang DingyuHan YangGong Rui - The search for new biomarkers that allow an early diagnosis in sepsis has become a necessity in medicine. This study aims to identify protein biomarkers that differentiate sepsis from non-infectious systemic inflammatory response syndrome (NISIRS), addressing the need for early sepsis diagnosis. - Source: PubMed
Publication date: 2026/04/24
Ruiz-Sanmartín AdolfoRibas VicentSuñol DavidChiscano-Camón LuisMartín LauraBajaña IvánBastida JulianaLarrosa NievesGonzález Juan JoséCarrasco María DoloresCanela NúriaFerrer RicardRuiz-Rodríguez Juan Carlos - Chronic kidney disease (CKD) affects approximately 14% of the UK population and is associated with significant exercise intolerance, partly due to skeletal muscle dysfunction. While exercise is a potential therapeutic strategy, the molecular response of skeletal muscle to exercise in CKD remains poorly understood. This study aimed to characterise transcriptomic changes in skeletal muscle 24 hours after aerobic (AE) or combined aerobic and resistance exercise (CE) in non-dialysis CKD. - Source: PubMed
Publication date: 2026/02/25
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