FKBP1B
- Known as:
- FKBP1B
- Catalog number:
- 000367A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- FKBP1B
Related genes to: FKBP1B
- Gene:
- FKBP1B NIH gene
- Name:
- FKBP prolyl isomerase 1B
- Previous symbol:
- FKBP1L
- Synonyms:
- OTK4, FKBP12.6, PPIase, FKBP9
- Chromosome:
- 2p23.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-02-15
- Date modifiied:
- 2018-11-01
Related products to: FKBP1B
Related articles to: FKBP1B
- Despite significant advancements in atopic dermatitis (AD) treatment, the underlying pathogenesis remains unclear. Understanding flare and remission mechanisms is essential for understanding disease course, evaluating treatment and developing therapeutic strategies. Although biomarkers show promise for assessing disease severity, their identification, validation and clinical utility demand further research. - Source: PubMed
Publication date: 2026/04/20
Olydam Jill IsabelleLitman ThomasNijsten TamarHoof IlkaKoopmann WittePardo Luba MilenaHijnen DirkJan - Early detection of Alzheimer's disease (AD) is critical for preventing disease progression. Blood platelets have emerged as a useful peripheral source for AD diagnosis. However, the identification of proteomics-based platelet biomarkers of mild cognitive impairment (MCI) and AD in relation to amyloid β (Aβ) deposition remains largely unexplored. In this study, we compared four groups from 18 participants: subjective memory impairment (SMI, n = 4) as cognitive normal controls, MCI without Aβ deposition (MCI-A(+), n = 5), MCI with Aβ deposition (MCI-A(-), n = 5), and AD (n = 4). We conducted in-depth platelet protein profiling using high-throughput LC-MS/MS with tandem mass tag labeling. Among the total 4,524 proteins detected, we identified both unique and overlapping differentially expressed proteins in MCI-A(+), MCI-A(-), and AD compared with SMI. Hierarchical clustering analysis revealed seven distinct patterns of proteomic alterations across groups. Functional network and gene ontology enrichment analyses indicated that each cluster was associated with specific processes, including platelet activation, AD, and apoptotic signaling pathways. Notably, upregulated proteins in MCI-A(-) and AD were linked to endomembrane system organization. Furthermore, we quantified the relative abundance of multiple protein candidates that were significantly altered in MCI-A(-) and AD compared with SMI and MCI-A(+). Our findings highlight several platelet proteins-ATP6V0C, AP4B1, RAB2B, PSMD9, FKBP1B, and mTOR-as potential molecular targets for predicting AD at the stage of MCI with Aβ deposition, providing new insights into amyloid-related neurodegeneration. - Source: PubMed
Publication date: 2026/03/28
Cho Yeong EunKim AndrewLee Hyeong MinOh Jae WonSon Sang JoonRoh Hyun WoongJung Yi-SookHong Chang HyungLee Sang YoonKim Kwang Pyo - The digestion of food is known to have significant hemodynamic and metabolic effects where many have not been fully investigated. The potential effect of food intake could be interesting both from a physiological point of view and from a methodological point of view, as it could affect when blood samples are collected. The objective of this study was to investigate the effect of food intake on 143 different predominantly inflammatory but also some organ damage biomarkers. Twenty-two healthy subjects (11 male and 11 female aged 25.9 ± 4.2 years) were investigated. A total of 143 biomarkers were measured before a standardized meal as well as 30 and 120 min afterwards with the Proseek Multiplex Inflammation I, and Multiplex Organ Damage panels, both using the Olink's Proximity Extension Assay. The levels for 23 biomarkers were significantly ( < 0.001) changed due to food intake. A total of 14 biomarkers decreased 30 min and 120 min after food intake. Four biomarkers were increased only at 120 min after food intake. The changes for the biomarkers were between 2% and 105%. This study shows that food intake has some effect on 143 different biomarkers. The timing of blood sampling in relation to food intake could be a concern when investigating Interleukin-6, Anterior gradient protein 2 homolog, BH3-interacting domain death agonist, Tyrosine-protein kinase Fes/Fps, Syntaxin-8, Probetacellulin, Peptidyl-prolyl cis-trans isomerase FKBP1B, Ribonucleoside-diphosphate reductase subunit M2 B, and Enteropeptidase, which all changed more than 30%. - Source: PubMed
Publication date: 2026/02/14
Dencker MagnusBjörgell OlaHlebowicz Joanna - Respiratory tract infections (RTIs) remain a major global cause of morbidity, yet the causal role of circulating plasma proteins in RTI susceptibility is unclear. We aimed to systematically identify plasma proteins that causally influence the risk of upper and lower respiratory tract infections (URTIs, LRTIs) using a proteome-wide Mendelian randomization (MR) framework. - Source: PubMed
Publication date: 2026/02/11
Yuan YuhuaLiu BinChen ShuhuiWang ManliZhao ShuyueMao Yingying - Hypertension (HTN) has been linked to changes in DNA methylation. However, longitudinal epigenome-wide analyses are still limited. - Source: PubMed
Publication date: 2026/02/04
Lai LiyeJong Angelina Shin YeeDelerue ThomasLin JieshengThorand BarbaraHeier MargitProkisch HolgerFarzeen AimanWinkelmann JulianeThiering ElisabethGieger ChristianPeters AnnetteWaldenberger Melanie