VEGF_D
- Known as:
- VEGF_D
- Catalog number:
- 000280A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- VEGF_D
Related genes to: VEGF_D
- Gene:
- VEGFD NIH gene
- Name:
- vascular endothelial growth factor D
- Previous symbol:
- FIGF
- Synonyms:
- VEGF-D
- Chromosome:
- Xp22.2
- Locus Type:
- gene with protein product
- Date approved:
- 1997-03-27
- Date modifiied:
- 2016-10-05
Related products to: VEGF_D
13.6 kDa protein,C-X-C motif chemokine 17,Cxcl17,Mouse,Mus musculus,Vcc1,VEGF co-regulated chemokine 1A-human VEGF IgG fr mon 100µgABT-869 ABT-869(Linifanib) is a structurally novel, potent RTK and VEGF and PDGF receptor families inhibitor with IC50 of 0.2, 2, 4, and 7 nM for human endothelial cells, PDGFR-beta, KDR, and CSF-1R,Anti- VEGF-Apan AntibodyAnti- VEGF-Apan antibodyAnti-bovine VEGF (164aa), liquid (PAB), Source: Polyclonal Rabbit, PABAnti-bovine VEGF (164aa), liquid (PAB), Source: Polyclonal Rabbit, PABAnti-Bovine VEGF-A (RABBIT) Antibody TRIAL SIZE (25ul)Anti-bovine VEGF-A PAbAnti-bovine VEGF-A PAbAnti-equine VEGF-A PAbanti-FLK1 (VEGF-R2) (FLK-6)anti-FLK1 (VEGF-R2) (FLK-6)anti-FLK1 (VEGF-R2) (FLK-6) type: Primary antibodies host: Mouseanti-FLT4 VEGF Receptor 3 (AFL4) Related articles to: VEGF_D
- The current number of emerging contaminants worldwide may reach tens of thousands. However, research on the extra-pulmonary toxicity induced by combined exposure of extremely low-dose emerging pollutants remains extremely limited. This study examined testicular injury induced by intratracheal instillation of two prevalent and frequently co-occurring emerging contaminants at ambient levels: polystyrene nanoparticles (PS) and perfluorooctane sulfonate (PFOS). With a 3 × 3 factorial design, male mice were intratracheally instilled with PS (0, 1.5 and 7.5 mg/kg) and/or PFOS (0, 5 and 25 μg/kg) once a week for 4 weeks. The instillation of PS in combination with PFOS induced more severe testicular histopathological injury, impairment of sperm counts and quality, reduced serum testosterone (T) levels and disruption of the blood-testis barrier (BTB). Furthermore, the testicular transcriptomic analysis identified the differentially expressed genes (DEGs) in the PS and PFOS co-exposure group, especially with Ldlr and Vegfd downregulation, and the DEGs were significantly enriched in vascular morphogenesis and development pathways and cholesterol metabolism pathways. In parallel, the protein expression of LDLR was decreased, the expression of testicular vascular endothelial markers (CD31 and VEGF) and tight junction proteins (ZO-1 and OCLN) was significantly reduced in the PS and PFOS co-exposure group compared with the control group (p < 0.05). Moreover, the testicular steroidogenic enzymes (StAR, CYP11A1, CYP17A1) were significantly reduced in the PS and PFOS co-exposure group compared with the control group (p < 0.05). Surprisingly, PS was detected in the testicular tissue in both PS and PS+PFOS groups. Our findings highlight an underappreciated risk of inhaling trace emerging pollutants mixtures on male fertility. - Source: PubMed
Publication date: 2026/04/23
Zhao LuweiChen YuweiPang GuanhuaLi YifeiHu RuokunXiao YuxinHe Miao - - Source: PubMed
Publication date: 2026/03/31
Saluja PrachiAtaya AliKircher KristenDiaz BriannaHelman DonaldGomez Rojas Olga RRuoss StephenWang Bonnie RKazerooni EllaGupta Nishant - Severe dengue is influenced by the virus serotype, viral load, host exposure status, immune response, host genetics, and other host factors. The objective of the present study was to identify a panel of prognostic markers for severe dengue during the viraemic phase. We investigated 326 real-time RT-PCR positive dengue cases to find out the association of viral load, antibody titers, and immune status. Plasma levels of 27 cytokines, chemokines, and endothelial cell-related factors were estimated in a subset of 206 patients. Viral load was lower in DENV-3 cases compared to DENV-1 and DENV-2 cases (p < 0.0001). Viral load was lower in secondary infections compared to primary infections, irrespective of serotypes (p < 0.0001). Viral load was not different between dengue patients without warning signs (DWOWS), dengue with warning signs (DWWS), and severe dengue. The total number of cytokines, chemokines, and growth factors produced above the assay detection threshold was higher in severe cases compared to DWOWS and DWWS (p < 0.05). Penalized multivariate regression identified significant associations between dengue serotype and IgM OD ratio, viral load (log₁₀), granulocyte colony-stimulating factor, interferon (IFN)-γ induced protein-10 (IP-10), and macrophage inflammatory protein-1β (MIP-1β) (p < 0.05), with good discrimination between DENV-1 and DENV-2 infections (area under the curve [AUC] = 81.11%). IgA OD ratio, viral load (log₁₀), interleukin-10 (IL-10), MIP-1α, syndecan-1 (SDC-1), and vascular endothelial growth factor-A were significantly associated with immune status, accurately distinguishing primary and secondary infections (AUC = 92.56%). IFN-γ, IL-1β, IL-1RA, IL-2, IL-6, IL-8, IL-10, IL-18, and TPO were significantly elevated in severe dengue cases compared to DWOWS and DWWS (p < 0.05). Exploratory penalized regression results suggested higher odds of the dengue severity with increasing levels of IgA, IgE, G-CSF, GM-CSF, IFN-α, IFN-γ, IL-1β, IL-1RA, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-17A, IL-18, IP-10, MCP-1, resistin, SDC-1, TNF-α, and VEGF-D (OR > 1 per standard deviation increase). To conclude, the present study suggests that a dysregulated immune response, indicated by elevated levels of cytokines, chemokines, and endothelial cell-related factors, occurs in the viraemic phase of severe dengue cases and can be exploited to design a panel of prognostic markers. - Source: PubMed
Alagarasu KalichamyGurav Yogesh KPulinchani AnishaBachal RupaliBhadale PradnyaTelmore AishwaryaKakade MahadeoSambhare SusmitSonare PratikshaNagvekar VasantBorse R TDravid AmeetSonali PalkarBarsode SupriyaPravin SoniDeepali AmbikePandve HarshalKale NarendraShinde VarshaMane ShailajaKanitkar ShubangiMakashir PracheeShah ParthNatarajan SripriyaAhmed Sheikh MinhajBagare PrasadBirru JoshuaKulkarni RajeshSalunkhe Shradha - Marrow-isolated adult multilineage inducible (MIAMI) cells are a subpopulation of mesenchymal stem/stromal cells (MSC) with enhanced self-renewal, multilineage plasticity, and anti-inflammatory properties, suggesting that their extracellular vesicles (MIA-EVs) may confer advantages over conventional MSC-EVs. MIAMI cells were transcriptionally profiled and expressed regenerative markers, including , , and . We report the first successful isolation and characterization of MIA-EVs. EVs were isolated by ultracentrifugation and characterized by nanoparticle tracking analysis, transmission electron microscopy, flow cytometry, and surface markers. Cargo analysis identified growth factors (, , ) and 19 highly expressed miRNA targeting survival, regenerative, and immune regulatory pathways. MIA-EVs were efficiently internalized, enhanced keratinocyte wound closure and suppressed osteosarcoma proliferation in vitro. Conditioned MIA-EVs reshaped pathway weighting without altering core regulatory identity, as a conserved 15-miRNA backbone persisted across naïve, irradiated, and cytokine-primed states. In contrast, a 9-miRNA core shared with MSC-EVs defined a basal mesenchymal framework, while MIA-EVs expanded regenerative, survival, and immune network connectivity. Similar to embryonic stem cell (ESC)-EVs, both MIA- and cytokine-primed EVs promoted M2 macrophage polarization, selectively upregulating and /, respectively. Meanwhile, MSC-EVs induced heterogeneous responses. These findings establish MIA-EVs as a conditioning-resistant, systems-regulated, cell-free platform with regenerative, immunomodulatory, and cytoprotective potential under hostile microenvironments. - Source: PubMed
Publication date: 2026/02/24
Ley Michelle B R GTemple H ThomasJackson Alicia RBest Thomas MKouroupis DimitriosD'Ippolito Gianluca - Disorders in pulmonary vascular integrity are a prominent feature in many lung diseases. Paracrine signaling is highly enriched in the lung and plays a crucial role in regulating vascular homeostasis. However, the specific local cell-cell crosstalk signals that maintain pulmonary microvascular stability in adult animals and humans remain largely unexplored. - Source: PubMed
Publication date: 2026/03/13
Yoon YongdaeSharma LokeshTang WenwenKirk ShannonRaredon Micha Sam BrickmanAhangari FaridaKhoury JohadQian HongKe YunboTulapurkar Mohan ELiu RuyaLuan YiYuan QianyingChen LujiaBirukov Konstantin GSimons MichaelWu DianqingNiklason Laura EKaminski NaftaliYuan Yifan