FOXO3
- Known as:
- FOXO3
- Catalog number:
- 000062A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- FOXO3
Related genes to: FOXO3
- Gene:
- FOXO3 NIH gene
- Name:
- forkhead box O3
- Previous symbol:
- FKHRL1, FOXO3A
- Synonyms:
- AF6q21, FOXO2
- Chromosome:
- 6q21
- Locus Type:
- gene with protein product
- Date approved:
- 1998-03-23
- Date modifiied:
- 2015-08-25
Related products to: FOXO3
Related articles to: FOXO3
- Cigarette smoke-mediated chronic pulmonary damage constitutes a critical predisposing factor for chronic obstructive pulmonary disease and lung cancer pathogenesis. Polydatin, a naturally occurring stilbenoid characterized by its potent anti-inflammatory and antioxidant properties, has yet to be fully elucidated regarding its protective role and the underlying molecular mechanisms in CSE-induced pulmonary injury. - Source: PubMed
Publication date: 2026/08/03
Lv LongfeiLu TianyuWang RuiLi XiangCui YoubinRen LiZhang Jie - Faced with the complexity and diversity of skin aging, it is critical to investigate multi-target synergistic anti-aging products. Herein, a novel composite hydrogel with anti-aging activity was developed based on Dendrobium polysaccharide, hyaluronic acid (HA), and nicotinamide (NMN). The hydrogen bond and van der Waals force were the main driving forces in the self-assembly interaction between Dendrobium polysaccharides (DDAM-1 and DOMOS), HA, and NMN. They also were important molecular mechanisms for the gel formation of the composite hydrogel, and the results have been confirmed by ITC and molecular docking. The composite hydrogel demonstrated potent anti-aging effect on the skin in vivo and in vitro, including inhibited elastase/collagenase, promoted type I collagen secretion, prevented ROS, and reduced the expression of IL-6/MMP-3. In addition, the anti-aging mechanism of the composite hydrogel may be associated with FOXO and TGF-β/Smad- SIRT1 signaling pathways mediated by FOXO3, SIRT1, SMAD3 and TGF-β. Briefly, this study demonstrates the potential of HA-infused composite hydrogels for use as anti-aging cosmetic products due to their synergistic anti-aging strategies for anti-aging applications. - Source: PubMed
Publication date: 2026/10/01
Zhang YanyeWang YuanheShao HuiyanGuo XingliXu PengchengLi YanlangJia JiankeDong FawuHu Jiang-MiaoYang Liu - Sarcopenia is a significant complication of chronic pancreatitis (CP), contributing to increased morbidity and adverse outcomes. Chronic inflammation and metabolic dysregulation may promote skeletal muscle wasting through catabolic signaling activation, though underlying molecular mechanisms remain incompletely understood. This study investigated molecular pathways associated with sarcopenia in CP. - Source: PubMed
Publication date: 2026/09/17
Lohani NeelamQamar SumairaVerma DeepikaGopi SrikanthSingh NidhiGunjan DeepakSharma Meher ChandaKanga UmaChauhan S SSingh NamrataDash N RPal SujoyKhan Imteyaz AhmadAgarwal SamagraSaraya Anoop - Ischemic stroke remains associated with substantial neurological disability, and effective strategies for cerebral ischemia-reperfusion injury (CIRI) are limited. Dihydromyricetin (DHM) has shown neuroprotective properties in experimental neurological disorders, but its effects and associated molecular mechanisms in CIRI remain incompletely understood. This study therefore evaluated the protective effects of DHM pretreatment and examined the signaling events associated with these effects in experimental CIRI. - Source: PubMed
Publication date: 2026/09/25
Tang YingyingWang XiaodanYe JiayuChen XiaopingLi JiamengZhu FangfangYang YingjieZhou XuelongChen Xinzhong - Primordial follicle activation is a critical determinant of female reproductive lifespan. Although forkhead box O3 (FOXO3) conservatively regulates primordial follicle dormancy in mammals, its role in avian species remains unknown. Using the herpes simplex virus thymidine kinase/ganciclovir (HSV-TK/GCV)-mediated germ cell ablation system, we generated germline chimeric chickens carrying FOXO3-overexpressing (OE-FOXO3) primordial germ cells (PGCs). Overexpression was confirmed by RT-qPCR and Western blot. Compared with WT, OE-FOXO3 PGCs showed inhibited proliferation but retained germline identity and migration. In vivo, OE-FOXO3 chimeras exhibited delayed primordial follicle activation. Quantitative follicle staging at 3, 4, 7, and 21 days post-hatch (dph) revealed that OE-FOXO3 ovaries consistently maintained a higher proportion of primordial follicles and fewer growing follicles. By 21 dph, this difference was most evident: OE-FOXO3 follicles remained dormant with sustained nuclear/perinuclear FOXO3, whereas control follicles progressed, showing cytoplasmic or peripheral granulosa cell FOXO3 staining. At 3 dph, OE-FOXO3 ovaries contained fewer germ cell clusters and reduced apoptosis. By 4 dph, coinciding with the onset of primordial follicle activation, Western blot analysis revealed that the PI3K/AKT signaling was significantly activated in the control ovaries, whereas this activation was suppressed in the OE-FOXO3 ovaries. Collectively, these findings provide the first in vivo evidence that FOXO3 functions as a negative regulator of primordial follicle activation in chickens. Notably, this suppressed activation state was associated with reduced PI3K/AKT signaling. This study extends the functional conservation of FOXO3 beyond mammals, offering new insights into avian ovarian reserve establishment. - Source: PubMed
Publication date: 2026/09/21
Lan MeiyuPeng RuiYang YaoyanJi NaJia XiaoxuanLiu XingtingPu LipingRan MingxiaLu Yangqing