Nod2
- Known as:
- Nod2
- Catalog number:
- 000055A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- Nod2
Related genes to: Nod2
- Gene:
- NOD2 NIH gene
- Name:
- nucleotide binding oligomerization domain containing 2
- Previous symbol:
- IBD1, CARD15
- Synonyms:
- BLAU, CD, PSORAS1, CLR16.3, NLRC2
- Chromosome:
- 16q12.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-07-10
- Date modifiied:
- 2019-04-23
Related products to: Nod2
Related articles to: Nod2
- Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) are critical intracellular pattern recognition receptors that orchestrate innate and adaptive immune responses. Their dysregulated activation is mechanistically linked to the pathogenesis of numerous inflammatory diseases. In endodontics, pulpitis and apical periodontitis represent highly prevalent inflammatory conditions, primarily caused by bacterial invasion, which significantly impact patients' quality of life. Current studies demonstrate that NLR-mediated immunity plays a significant role in driving pulpal inflammation and periapical bone resorption. - Source: PubMed
Publication date: 2026/09/01
Zhang XinyeLi YuanyuanLi HuiliLin ChenTao Huangheng - Yersinia enterocolitica and Yersinia pseudotuberculosis have been identified as microbiological factors in the multifactorial pathophysiology of inflammatory bowel disease (IBD). Although conventionally associated with self-limiting gastroenteritis, Yersinia has been increasingly investigated for its potential role in IBD, particularly in genetically predisposed individuals. Whether this reflects causality, opportunistic colonization, or secondary enrichment within inflamed tissue, however, remains unresolved. Polymerase chain reaction (PCR)-based studies have detected Yersinia DNA in the intestinal tissues of patients with IBD, and epidemiological studies have suggested an association between prior Yersinia infection and an increased long-term risk of disease. However, because most evidence is based on PCR detection, with limited culture-based confirmation of viable organisms and infrequent sequencing of PCR amplicons, these findings do not establish active infection or a causal relationship. These pathogens exploit abnormalities in the epithelial barrier and compromised mucosal immunity through type III/VI secretion systems to disrupt host responses, activate inflammasomes, and induce pyroptosis. Polymorphisms in autophagy-related genes, such as NOD2 and ATG16L1, impair pathogen clearance and increase susceptibility. While antibiotics continue to be effective against invasive diseases, the rise of resistance highlights the necessity for alternatives. Probiotic-based strategies have demonstrated immunomodulatory, antimicrobial, and barrier-protective effects in preclinical models, although their therapeutic efficacy in IBD requires further clinical validation. Comprehending Yersinia-host genetic interactions could facilitate precision diagnostics and microbiota-targeted treatments in IBD. - Source: PubMed
Sabzehali FattanehZerbato VerenaBella Stefano DiMorabito StefanoZali Mohammad RezaYadegar Abbas - One of the key hallmarks of aging is the age-related decline in immune system function, accompanied by a chronic low-grade inflammation, or "inflammaging". Simultaneously, a reduced capacity of immune cells to recognize and eliminate pathogens, along with immune exhaustion, is also defined as a sign of aging. Cynomolgus macaques () belong to a group of non-human primates evolutionarily close to humans and are often used for preclinical research. - Source: PubMed
Publication date: 2026/08/13
Petrova Viktoria MBulgin Dmitry VRadomskaya Elena YuShevelov Vsevolod AZhukova Darya SChzhu Olga PManakhov Andrey DPopov Alexander VRybtsov Stanislav A - The gut microbiota plays a crucial role in immune regulation and metabolic homeostasis in ruminants; however, the systemic effects of rumen fluid transfer (RFT) on the gut-liver axis remain unclear. In this study, Xizang sheep were used as the animal model to investigate the effects of RFT using multi-omics approaches, including transcriptomics, metabolomics, and 16S rRNA sequencing. The results showed that RFT was associated with changes in immune- and metabolism-related genes (e.g., TLR4, NOD2, PPARA, and ABCG2) and alterations in several key metabolites, including tryptophan-related compounds, amino acids, and bile acid-associated metabolites. RFT was also associated with shifts in gut microbial composition, as reflected by changes in the relative abundance of genera such as Prevotella, Ruminococcus, and Lactobacillus. Integrated multi-omics analysis indicated coordinated associations among gut microbiota, metabolites, and host gene expression along the gut-liver axis. These findings indicate that RFT may be linked to immune and metabolic regulation in Xizang sheep, providing a systems-level framework for understanding microbiota-host interactions. - Source: PubMed
Publication date: 2026/08/24
Luo XiaofengZhaxi YangzongPan JunruZhang ZhenzhenLi JingjingChen TingxianYe WenruiLi HaiyanMa HongcaiShahzad KhuramLuosang Wang GaofuSong TianzengZhao Wangsheng - Sepsis is a life-threatening condition characterized by severe organ dysfunction resulting from an uncontrolled host response to infection. Sepsis treatment poses a challenge due to its complexity and the need for effective therapeutic approaches. The objective of this study was to evaluate the immunomodulatory and antimicrobial effects of exopolysaccharides (EPS) from Auricularia auricula in a murine model of lethal sepsis. Our findings demonstrated that treatment with EPS significantly enhances the proliferation of circulating lymphocytes and granulocytes, which is associated with improved host defense mechanisms. Additionally, EPS administration effectively mitigates sepsis-induced pulmonary damage, as evidenced by preserved lung function. Furthermore, EPS treatment significantly reduces microbial translocation to the bloodstream, maintaining a lower colony-forming unit (CFU) count and thereby restricting systemic infection. The polysaccharides also prevent the development of thrombocytopenia in septic animals, thereby preserving platelet homeostasis. The compound modulates serum cytokine profiles, contributing to a more regulated inflammatory response. The interactome analysis reveals that the Dectin-1 → Syk pathway activates NF-κB/AP-1 and involves p38 MAPK, thereby explaining the observed cytokine modulation. The presence of Nod2/Ripk2 suggests that the EPS primes leukocytes to effectively combat both fungi and bacteria, leading to a reduced bacterial load and increased survival. Collectively, these data indicate that EPS, a prebiotic agent, represents a novel therapeutic strategy with potential for modulating immune responses, controlling microbial proliferation, and improving survival outcomes in a model of severe sepsis. - Source: PubMed
Viana Jesse Pereira MachadoCoelho Luisa CoutinhoMendes Priscila MVale André Alvares MarquesCasarin Jeferson NoslenSousa Joicy Cortez de SáPereira Paulo Vitor SoeiroLeal Maria Carolina B Di MedeirosBocca Anamelia LMaciel Márcia C G