AKT1
- Known as:
- AKT1
- Catalog number:
- 000039A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- AKT1
Related genes to: AKT1
- Gene:
- AKT1 NIH gene
- Name:
- AKT serine/threonine kinase 1
- Previous symbol:
- -
- Synonyms:
- RAC, PKB, PRKBA, AKT
- Chromosome:
- 14q32.33
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
Related products to: AKT1
Related articles to: AKT1
- Postoperative delirium (POD) and Alzheimer's disease (AD) are increasingly recognized as related neurocognitive conditions, but the aging-associated cell states that may connect them remain poorly defined. Here, we integrated two brain transcriptomic discovery datasets analyzed at single-cell/single-nucleus resolution, including a POD-related cohort (GSE291019) and an AD cohort (GSE129308), together with two independent peripheral-blood bulk transcriptomic datasets (GSE163943 and GSE63060), to identify aging-associated cellular programs and prioritize convergent molecular candidates. Across 184,168 high-quality cells, inhibitory neurons showed the most consistent aging-associated perturbation across the POD- and AD-related datasets. Re-clustering further identified three inhibitory-neuron subtypes, Inh_Neurons2, Inh_Neurons3, and Inh_Neurons5, with relatively high aging-related gene activity and preferential localization to later pseudotime states. Cross-platform integration of aging-associated inhibitory-neuron genes with a shared bulk DEG set identified four convergent candidates: RGL2, AKT1, SYK, and TNFSF13B. Among them, RGL2 emerged as the leading candidate, with the strongest downstream support concentrated in AD-related analyses. In two-sample Mendelian randomization, genetically predicted higher RGL2 expression was associated with increased AD risk, whereas the estimate for the delirium genome-wide association study proxy used for POD-related analyses was not significant. Pathway analyses further linked higher RGL2 expression to complement/coagulation and innate immune-inflammatory programs in AD-related analyses. These findings suggest a model in which POD and AD may partially intersect through aging-vulnerable inhibitory-neuron states and identify RGL2 as a prioritized candidate for downstream mechanistic investigation. - Source: PubMed
Publication date: 2026/08/29
Fan WeiHan ShuaiWang CunjingGao Ju - This study investigated the molecular characteristics and functions of buffalo prolactin (PRL) in the lactation. The buffalo gene's complete coding sequence (CDS) is 690 bp, encoding 229 amino acids, with structure and function highly consistent with other Bovidae species. expression was significantly higher in the buffalo mammary gland during lactation compared to the non-lactating period, highlighting its crucial role in lactation. overexpression in buffalo mammary epithelial cells (BuMECs) promotes cell proliferation and increases the casein secretion and triglyceride (TAG) accumulation. This occurs through the activation of the JAK2-STAT5 (cell differentiation, casein () gene transcription, and lipid factor transcription), PI3K-AKT-mTOR (cell growth, milk protein gene translation, and lipid factor activation), and mitogen-activated protein kinase (MAPK; cell proliferation and stress mitigation) signaling pathways. Specifically, overexpression upregulated the mRNA expression of genes in these pathways, such as , , , , , , and , while decreasing and . Overexpression also increased the expression of cell cycle genes (, , /), and enhanced cell viability. Furthermore, overexpression led to increased expression of casein genes (, ) and milk-fat-synthesis-related genes (, , , , ). Population genetic analysis identified five single-nucleotide polymorphisms (SNPs) in the buffalo CDS, with c.34C T and c.430T C being non-synonymous substitutions that were predicted to affect protein function. This research provides a theoretical foundation for genetic interventions aimed at improving buffalo lactation traits. - Source: PubMed
Publication date: 2025/12/03
Huang LigeFan XinyangTeng XiaohongQian LindongBao ZhipengMiao Yongwang - Diabetes mellitus is commonly featured with cardiac microvascular dysfunction and chronic low-grade inflammation, contributing to the progression of diabetic cardiomyopathy (DCM). Finerenone confers cardio-renal protection in diabetic settings, yet its underlying mechanisms remain incompletely defined. - Source: PubMed
Li SuZhang HexiLiu MuyinZhu WentaoYan XiaopeiQiu WenyanTian YuanLian XiaoyuLu DanboChen ZhangweiChen ChaoChen YuqiongQian Juying - Cerebral infarction (CI) represents a central nervous system vascular disorder characterized by high risks of disability and fatality. Quercetagetin (RG, 6-Hydroxyquercetin), a flavonoid isolated from Carthami Flos, has therapeutic potential against cerebral infarction. This research investigates its action mechanisms. - Source: PubMed
Publication date: 2026/08/27
Ren YuleLi HongmiaoLi CongWang YahongJia Wenyan - Euphorbia members (Euphorbiaceae) are valuable sources of lead compounds for potential drug discovery. This study was conducted to evaluate, for the first time, the phytoconstituents, antioxidant capacity, enzyme inhibitory, and cytotoxic properties of . Extracts were prepared from the aerial parts using ethyl acetate (EtOAc), ethanol (EtOH), 70% EtOH, and water. Results showed that the 70% EtOH and EtOH extracts contained the highest levels of total phenolics (68.12 mg GAE/g) and flavonoids (45.49 mg RE/g). UPLC-ESI-MSn analysis revealed a variety of phytochemicals, including flavonoids, cinnamic acid derivatives, tannins, triterpenoids, and saponins, with 24 metabolites tentatively identified. PCA grouped these metabolites into three clusters, and their distribution was visualized with a heatmap. Polar extracts demonstrated strong antioxidant activity, with the 70% EtOH extract showing the highest values in most assays (DPPH = 385.50 mg TE/g; ABTS = 466.31 mg TE/g; CUPRAC = 439.95 mg TE/g; FRAP = 305.07 mg TE/g; PBD = 2.45 mmol TE/g). The EtOH and EtOAc extracts exhibited the strongest anti-acetylcholinesterase (2.83 mg GALAE/mg) and anti-butyrylcholinesterase (2.18 mg GALAE/mg) activities, respectively. Both the 70% EtOH and EtOH extracts showed the best anti-tyrosinase effects (54.40 and 53.39 mg KAE/g; ≥ 0.05). The EtOAc extract was more toxic toward SHSY5Y cells, with a viability of 4.31%, compared to 8.18% in normal KEK293 cells. Network pharmacology identified 11 common targets for metabolites, with AKT1, EGFR, GSK3B, ESR1/ESR2, and CCND1 serving as key hubs. Pathway enrichment analysis highlighted PI3K-Akt, EGFR, and hormone-related pathways. Docking and molecular dynamics simulations confirmed stable multi-target binding. These findings suggest that could be a promising source of antioxidants and compounds with potential anticancer and enzyme-inhibitory activities relevant to human diseases. - Source: PubMed
Publication date: 2026/08/26
Yagi SakinaElhawary Esraa AEldahshna Omayma ASingab Abdel Nasser BCetiz Mehmet VeysiUba Abdullahi IbrahimYapıcı IsmailGulcin IlhamiFernandes ElianaCustódio LuísaRodrigues Maria JoãoYildiztugay EvrenZengin Gokhan