Flna
- Known as:
- Flna
- Catalog number:
- 065389A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- Flna
Related genes to: Flna
- Gene:
- FLNA NIH gene
- Name:
- filamin A
- Previous symbol:
- FLN1, FLN, OPD2, OPD1
- Synonyms:
- ABP-280
- Chromosome:
- Xq28
- Locus Type:
- gene with protein product
- Date approved:
- 1993-03-18
- Date modifiied:
- 2019-04-23
Related products to: Flna
Anserine Filamin A, Alpha Elisa Kit (FLNa)Anserine anti - Filamin A, Alpha Elisa Kit (FLNa)anti-FLNA FMD (4E10-1B2)anti-FLNA FMD (4E10-1B2) type: Primary antibodies host: MouseAnti-FLNA (4E10-1B2), Mouse Monoclonal to FLNA, Isotype IgG1, Host Mouseanti-FLNA / FMDanti-FLNA / FMD (4E10-1B2)Bovine Filamin A, Alpha ELISA , FLNaBovine Filamin A, Alpha ELISA , FLNaBovine Filamin A, Alpha Elisa Kit (FLNa)CAMK2G & FLNA Protein Protein Interaction Antibody PairCAMK2G & FLNA Protein Protein Interaction Antibody Pair pairsCanine Filamin A, Alpha ELISA , FLNaCanine Filamin A, Alpha ELISA , FLNaCanine Filamin A, Alpha Elisa Kit (FLNa) Related articles to: Flna
- Filamin A (FLNA) is an actin-binding protein that regulates mechanosensitivity and functions as an intracellular signaling scaffold in various cell types. It has also been implicated in tumor growth. We recently reported FLNA expression in human ovarian granulosa cells and in KGN cells, a granulosa cell tumor (GCT) line. - Source: PubMed
Publication date: 2026/05/20
Jiang YuhaoCaban Karolina MagdalenaPeitzsch MirkoHerrmann CarolaMayr DorisStöckl Jan BerndFröhlich ThomasMayerhofer ArturMüller-Taubenberger AnnetteWelter Harald - Intramuscular fat (IMF) plays an important role in determining meat quality traits such as flavor, tenderness, and juiciness. While numerous studies have investigated the genetic basis of IMF in commercial pig breeds, data on local breeds remain rather limited. In this study, we used RNA-sequencing to characterize the transcriptomic differences between high-IMF and low-IMF Black Slavonian pigs, a native Croatian breed known for superior meat quality. Muscle samples (Longissimus thoracis et lumborum) from 14 pigs with divergent IMF levels were collected shortly after slaughter, preserved in liquid nitrogen, and stored at - 80 °C until RNA extraction. Intramuscular fat content was determined from the same muscle 24 h post mortem using the Soxhlet extraction method (ISO 1443:1973). These samples were then analyzed to identify differentially expressed genes (DEGs) and enriched pathways. A total of 519 genes were differentially expressed (p ≤ 0.05), with 457 remaining significant after false discovery rate correction. The high-IMF group exhibited upregulation of genes associated with lipid metabolism (e.g., SCD, ADIPOQ, CIDEC, FABP4), PPAR signaling, and adipogenesis, while genes linked to muscle structure and oxidative metabolism were downregulated. Functional enrichment and gene set enrichment analyses highlighted coordinated regulation of pathways related to fatty acid biosynthesis, extracellular matrix (ECM) remodelling, angiogenesis, and Notch signaling. Notably, several ECM-related genes (LAMA1, TIMP4) and angiogenic factors (FGF2, NRP1) were significantly upregulated, suggesting that adipocyte expansion in muscle requires parallel vascular and structural adaptations. Importantly, several of the top 30 DEGs, including EHD2, NRG4, UTRN, FLNA, and HMCN1, represent novel candidate genes not previously linked to IMF in pigs, pointing to potential breed-specific mechanisms. These genes are associated with membrane trafficking, paracrine signalling, cytoskeletal re-modelling, and ECM dynamics. Our findings contribute new molecular insights into IMF regulation in local pig breeds and provide a foundation for developing targeted breeding strategies to improve pork quality through intramuscular fat enhancement. - Source: PubMed
Publication date: 2026/05/20
Lukic BorisLipavić GoranBulaić MatejaIno CurikRadišić ŽarkoLužaić RasRaguž Nikola - Diabetic retinopathy (DR) is a major cause of severe visual impairment, where early diagnosis and intervention are crucial to prevent irreversible damage. Given that obtaining biomarkers from ocular fluids is highly invasive, we here leverage bioinformatic approaches to identify novel biomarkers and potential therapeutic drugs in the peripheral blood of patients with DR. - Source: PubMed
Publication date: 2026/05/14
Chen DiWu GuanrongLiao ShuoxinZhu HaoxianLi FangfangLiu ChangZhao HongyueMeng QianliFang Xiang - Bisphenol A (BPA), a prevalent endocrine-disrupting chemical, is associated with osteoporosis (OP). However, the key molecular targets and mechanisms remain unclear. - Source: PubMed
Publication date: 2026/05/12
Wang ZhenyangChen YongqinMa JilingYang YuxuanLi KeJiao XiejiaXu BitengShi GuidongWang LiangQi Lei - Extracellular vesicles (EVs) are promising to provide chemical predictors toward clinical diagnosis and prognosis. However, the isolation of high-purity EVs from complex bodily fluids is a little complex. To address this issue, a choline phosphate (CP)-functionalized adsorbent, designated as SCF@CP-Et, was prepared by grafting 2-(isopropylacryloyloxy)ethyl choline phosphate (CP-Et) from the surface of sulphydryl cotton fiber (SCF) via thiol-ene click polymerization. The SCF@CP-Et indicates a high-efficiency EV enrichment capability arising from the multivalent coordination interaction between the CP groups and phosphatidylcholine (PC) on EV membrane surface, meanwhile possesses an excellent anti-protein adsorption performance derived from the abundant hydroxyl groups of cotton fiber and zwitterionic property of CP-Et. Besides, this cotton fiber is easily assembled into a cotton fiber-in-syringe solid-phase extraction (SPE) device. This device shows simple and convenient operation during the isolation of EVs from various samples, including cell culture medium, plasma and urine. Meanwhile, the released EVs can maintain their biological activity. Taking advantage of these properties, this method was employed to isolate EVs in the plasma of colorectal cancer (CRC) patients and healthy donors, and 69 up-regulated and 18 down-regulated proteins are identified by proteomics analysis. Most of these up-regulated proteins, such as TLNA, FLNA, ITGB3 and MYH9, are associated with the progression of CRC, demonstrating the potential of this carbon fiber-based SPE method in the EV-based early diagnosis of diseases. - Source: PubMed
Publication date: 2026/04/17
Chen MengxiTang YingyingJiang ZiyiZhang JingZhang HaiyangWei Yinmao