Gata3
- Known as:
- Gata3
- Catalog number:
- 060166A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- Gata3
Related genes to: Gata3
- Gene:
- GATA3 NIH gene
- Name:
- GATA binding protein 3
- Previous symbol:
- -
- Synonyms:
- HDR
- Chromosome:
- 10p14
- Locus Type:
- gene with protein product
- Date approved:
- 1992-11-03
- Date modifiied:
- 2016-10-05
Related products to: Gata3
Related articles to: Gata3
- Papillary renal neoplasm with reverse polarity (PRNRP) is a rare renal tumor with distinct histomorphologic features and a strong association with KRAS exon 2 mutations, typically at codon 12. We report two cases that expand the molecular spectrum of this entity. The first tumor, a 3.5 cm mass in a 51-year-old female, harbored the classic KRAS codon 12 mutation (p.G12V), whereas the second, a 2.0 cm mass in a 77-year-old female, exhibited a KRAS p.Q61K mutation, rarely reported in PRNRP. Both tumors showed characteristic histology (tubulopapillary architecture, eosinophilic cytoplasm, apical nuclear polarity) and immunoprofile (GATA3+, CK7+, SDHB-retained, FH-retained). Next-generation sequencing using a 505-gene cancer panel also detected additional alterations in FLT3, POLD1, KMT2C, and WHSC1, the significance of which remains uncertain currently but may emerge with more molecular data from additional PRNRP cases. These findings underscore the value of integrated histopathologic and molecular evaluation, highlight KRAS Q61K as a rare variant, and provide a foundation for future genomic studies in this tumor type. - Source: PubMed
Publication date: 2026/07/15
Zhou GangDong XiuhuaLiu Lina - Hypoparathyroidism, deafness, and renal dysplasia (HDR) syndrome is a rare autosomal dominant disorder caused by GATA-binding protein 3 (GATA3) haploinsufficiency. Although the clinical triad is well recognized, the phenotype is often incomplete, making clinical diagnosis challenging. This study aimed to elucidate the clinical and genetic characteristics of HDR syndrome in a kidney disease cohort. - Source: PubMed
Publication date: 2026/08/13
Tanaka YuNagano ChinaAsagai YoshikiHanafusa HiroakiHorinouchi TomokoSakakibara NanaYamamura TomohikoIshimori ShingoKaito HiroshiIijima KazumotoNozu KandaiMorisada Naoya - Primary breast neuroendocrine carcinomas (NECs) are rare, high-grade malignancies that are frequently grouped with invasive breast carcinomas with neuroendocrine differentiation (IBC-NED), despite uncertain biological equivalence. We sought to define the clinicopathologic, immunophenotypic, and genomic features of breast NEC and to determine whether they represent a biologically distinct entity. - Source: PubMed
Publication date: 2026/08/13
Schwartz Christopher JMack TannerTravis WilliamZhang HongAbuhadra NourKiernan RisaMontagna GiacomoBrogi EdiPareja FresiaWen Hannah YRoss Dara S - Benign multicystic peritoneal mesothelioma is a rare mesothelial neoplasm with fewer than 200 reported cases, typically arising on peritoneal or pelvic surfaces in premenopausal women. We describe a 21-year-old woman with a 2-week history of left lower abdominal pain. Magnetic resonance imaging showed a multiloculated cystic retroperitoneal mass adherent to the sigmoid colon, with normal ovaries and uterus. CA-125 was mildly elevated. At laparotomy, the mass was confirmed to be retroperitoneal without ovarian involvement, requiring en-bloc excision with sigmoid colectomy and primary anastomosis. Histopathology showed flat-to-cuboidal mesothelial cells with a hobnailing pattern in fibromyxoid stroma; immunohistochemistry was positive for calretinin and WT-1, and negative for SALL4, GATA3, and CD31, confirming benign multicystic peritoneal mesothelioma. At 6-month follow-up she remained asymptomatic with no recurrence on imaging. This case highlights BMPM as a mimicker of primary retroperitoneal neoplasms and the potential need for bowel resection to achieve complete excision. - Source: PubMed
Publication date: 2026/08/12
Amaireh Enas AAl-Natour OsamaNour Maen AbdelMahfouz Ismaiel Abu - Primary small cell neuroendocrine carcinoma (SCNC) of the bladder is an exceptionally aggressive malignancy. We report the case of an 80-year-old male, a chronic smoker, presenting with an 8-month history of intermittent total hematuria. Cystoscopy revealed a 72 mm mass infiltrating the bladder dome, posterior, and lateral walls. Histopathological analysis of transurethral resection specimens demonstrated a necrotic diffuse proliferation of monomorphic small cells infiltrating the muscularis propria. Immunohistochemistry showed positivity for synaptophysin, chromogranin A, CD56, and TTF1, whereas GATA3 and p63 were negative. The Ki-67 index exceeded 90%. Systemic staging (cT3bN0M0) confirmed the primary bladder origin. Although multimodal management, including neoadjuvant chemotherapy and radical cystoprostatectomy, was recommended, the patient-initiated chemotherapy but declined surgery. Primary bladder SCNC is a highly invasive entity requiring early diagnosis and multidisciplinary care. The diagnosis is strictly anatomopathological. Differentiating this entity from primary pulmonary small cell carcinoma is a critical challenge, making systemic radiological staging mandatory. - Source: PubMed
Publication date: 2026/08/12
Mesmoudi SihamMiko Ali MohammedBencheikh SalmaAaboudech Taha YassineDerqaoui SabrineJahid AhmedBernoussi ZakiyaBouhnib AyoubMesbahi SaadIbrahimi AhmedZnati Kaoutar