Ccl11
- Known as:
- Ccl11
- Catalog number:
- 057717A
- Product Quantity:
- 250ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- Ccl11
Related genes to: Ccl11
- Gene:
- CCL11 NIH gene
- Name:
- C-C motif chemokine ligand 11
- Previous symbol:
- SCYA11
- Synonyms:
- eotaxin, MGC22554
- Chromosome:
- 17q12
- Locus Type:
- gene with protein product
- Date approved:
- 1996-04-24
- Date modifiied:
- 2016-10-05
Related products to: Ccl11
Anti-human Eotaxin (CCL11), bt, Source: Polyclonal bt. Goat, PABAnti-human Eotaxin (CCL11), bt, Source: Polyclonal bt. Goat, PABAnti-human Eotaxin (CCL11), bt, Source: Polyclonal bt. Goat, PABAnti-human Eotaxin (CCL11), bt, Source: Polyclonal bt. Rabbit, PABAnti-human Eotaxin (CCL11), bt, Source: Polyclonal bt. Rabbit, PABAnti-human Eotaxin (CCL11), bt, Source: Polyclonal bt. Rabbit, PABAnti-human Eotaxin (CCL11), Source: Polyclonal Goat, PABAnti-human Eotaxin (CCL11), Source: Polyclonal Goat, PABAnti-human Eotaxin (CCL11), Source: Polyclonal Goat, PABAnti-human Eotaxin (CCL11), Source: Polyclonal Rabbit, PABAnti-human Eotaxin (CCL11), Source: Polyclonal Rabbit, PABAnti-human Eotaxin (CCL11), Source: Polyclonal Rabbit, PABAnti-Mouse CCL11 (Eotaxin) Purified 50 ugAnti-Mouse CCL11 (Eotaxin) Purified 500 ugAnti-murine Eotaxin (CCL11), bt, Source: Polyclonal bt. Rabbit, PAB Related articles to: Ccl11
- Allergic conjunctivitis (AC) is a prevalent ocular surface inflammatory disorder with limited therapeutic options. In this study, we investigated the role of colony-stimulating factor 1 receptor (CSF1R) in an ovalbumin (OVA)-induced murine model of AC. Conjunctival expression of CSF1R and its ligands, interleukin-34 (IL-34) and colony-stimulating factor 1 (CSF1), was significantly upregulated following OVA challenge. Pharmacological inhibition of CSF1R with BLZ945 alleviated clinical symptoms, reduced the infiltration of CD45⁺ leukocytes and eosinophils, and attenuated an M2-associated macrophage phenotype in the conjunctiva. Similar suppression of eosinophil infiltration was observed with a second CSF1R inhibitor, AZD7507. In addition, conjunctival CD206⁺ macrophages with an M2-associated phenotype expressed C-C motif chemokine ligand 11 (CCL11), which was elevated in AC and downregulated by CSF1R inhibition. Recombinant CCL11 significantly restored eosinophil infiltration in BLZ945-treated mice, supporting a role for CCL11 as a downstream effector of CSF1R signaling in this model. Collectively, these findings support a contributory role for CSF1R signaling in macrophage-associated eosinophilic inflammation in murine AC and suggest that targeting CSF1R may represent a potential therapeutic strategy for ocular allergic disease. - Source: PubMed
Publication date: 2026/05/08
Du JinghengWu JiaxinTan XiukuiXie JingbinZhuang ZhudanLan HuifeiXue YunxiaFu TingGu JingyiLi ZhijieLiu Jun - Heat stress (HS) affects female reproductive efficiency by disrupting redox homeostasis and activating inflammatory responses in the corpus luteum (CL), a metabolically active tissue essential for pregnancy maintenance. This study reveals the protective effect of resveratrol against HS-induced luteal injury in pregnant mice through the regulation of oxidative stress and cytokine-chemokine-mediated inflammatory and immune responses. The pregnant mice were divided into three groups: control, HS, and resveratrol +HS. Heat stress was applied at 40 ± 0.5 °C for 7 days, with resveratrol (10 mg/kg) given orally 2 h before exposure to HS. The results showed that heat exposure reduced serum total superoxide dismutase activity and increased malondialdehyde level, causing significant disruption of luteal morphology with cellular disorder and vacuolization, which was partially overcome by resveratrol pretreatment. Transcriptomic profiling showed that HS induced a strong immunological and inflammatory response, involving cytokine-cytokine receptor interaction and chemokine signaling. Resveratrol significantly attenuated HS-induced transcriptional changes. The RT-qPCR results showed that HS increased chemokine ligands (, , ) and cytokine receptors , , ), which were suppressed by resveratrol. The chemokine-based inflammatory module is one of the most important regulatory properties of the HS response, according to the network analysis. Stable binding of resveratrol with major chemokine receptors was supported by molecular docking and molecular dynamics simulations. Collectively, HS induces oxidative, structural, and inflammatory alterations in luteal tissue, while resveratrol attenuates these changes by being associated with improved antioxidant status and suppression of cytokine-chemokine-mediated responses. - Source: PubMed
Publication date: 2026/04/14
Tariq MuhammadQuddus AbdulVictor Kossinga Koulet André SaintBeshah Kebede HabtegiorgisYan YexiaoMao Dagan - To identify candidate biomarkers of blood stasis syndrome (BSS) associated with coronary artery disease (CAD) and explore the underlying inflammatory mechanisms. - Source: PubMed
Hongzheng L IGuosheng LinYuxuan PengAlexey Viktorovich ChurovWenwen YangJie WangJieming L UFeifei LiaoRuotong Y UYue WeiZhiru ZhaoAimei L UPeng L IAling ShenLinzi LongHua Q UChanggeng F U - - Source: PubMed
Publication date: 2026/04/21
Yang Hyun-WooJo Yeong-InYang Hwa-EunPark Joo-HooSon Hyeong-GukMoon Jee WonPark Il-Ho - Recent studies have highlighted the critical role of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) in inflammation, with inhibitors like 3PO showing therapeutic potential in various inflammatory diseases. However, its effect on asthma inflammation remains unclear. - Source: PubMed
Publication date: 2026/04/02
Huang SiqingWei ShunaLuo FangCheng Yuanxiong