CD95 _ FAS
- Known as:
- CD95 _ Fas Cell Surface Death Receptor
- Catalog number:
- MC103
- Product Quantity:
- 100 Tests
- Category:
- -
- Supplier:
- ACR
- Gene target:
- CD95 _ FAS
Related genes to: CD95 _ FAS
- Gene:
- FAS NIH gene
- Name:
- Fas cell surface death receptor
- Previous symbol:
- FAS1, APT1, TNFRSF6
- Synonyms:
- CD95, APO-1
- Chromosome:
- 10q23.31
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-25
- Date modifiied:
- 2019-04-23
Related products to: CD95 _ FAS
Related articles to: CD95 _ FAS
- Elevated saturated fatty acids (SFAs) have generally been associated with higher cardiovascular risk, whereas emerging evidence suggests that long- and very-long-chain SFAs (LVLSFAs) may be inversely associated with cardiometabolic outcomes. - Source: PubMed
Publication date: 2026/08/05
Ramezankhani AzraHadaegh PartoAbiri BehnazHadaegh Farzad - In natural environments, animals must detect behaviorally relevant odors despite variability in both odor mixture composition and stimulus intensity. Although mice can identify salient odors embedded in complex mixtures, how target concentration and background complexity jointly constrain discrimination remains unclear. We trained mice in a two-alternative forced choice task to identify target odors embedded in mixtures containing up to 16 background components. After performance stabilized, we systematically varied target odor concentration. Discrimination accuracy declined with decreasing target concentration but showed little additional dependence on background complexity. Using a biophysically grounded model of olfactory bulb glomerular responses, we show that linear decoding reproduces behavioral performance when intrinsic neural noise dominates over background-driven variability. Manifold capacity analysis revealed that neural representations remain efficiently structured for odor discrimination despite variation in background complexity. These results define a noise-limited regime of olfactory discrimination in which target detectability is primarily constrained by neural sensitivity rather than background interference. - Source: PubMed
Publication date: 2026/08/20
McCalmon HannahCai GeorgeTsibouris ConstantineHamou NoéHoskins JoPashakhanloo FarhadChung SueYeonKapoor VikrantMurthy Venkatesh N - Fatty acids (FAs) play critical neurodevelopmental roles, yet associations with executive function among children affected by perinatal HIV remain poorly characterized. This prospective cohort study examined associations between serum FAs and caregiver-reported executive function and evaluated effect modification by perinatal HIV status among 6-10-year-old Ugandan children who had perinatal HIV infection (CPHIV; n = 84), were HIV exposed but uninfected (CHEU; n = 78), or were HIV unexposed and uninfected (CHUU; n = 81). Serum FAs were measured at enrollment, and executive dysfunction was assessed at enrollment, 6, and 12 months (Executive Functioning Index (EFI) and Global Executive Composite (GEC)). Multivariable linear mixed models estimated overall and HIV-specific mean differences (MDs) and 95% confidence intervals (CIs) in executive dysfunction z-scores by FA tertiles. Moderate versus low arachidonic acid (MD [95% CI] EFI: -0.40 [-0.71, -0.09]; GEC: -0.30 [-0.58, -0.03]) and highly unsaturated FAs (HUFAs; EFI: -0.41 [-0.72, -0.11]) associated with lower executive dysfunction. Among CPHIV, high Mead acid (20:3 (n-9)) associated with higher executive dysfunction (EFI: 0.56 [0.11, 1.01]). Among CHEU, lower executive function was associated with high docosatetraenoic acid (EFI: -0.93 [-1.71, -0.15]) and docosahexaenoic acid (GEC: -0.78 [-1.26, -0.31]). These results showed that higher HUFAs associated with better executive function, particularly among CHEU, supporting further nutritional intervention research for children affected by perinatal HIV. - Source: PubMed
Cardino Vanessa NGiordani BrunoSikorskii AllaZalwango Sarah KFenton Jenifer IEzeamama Amara E - BackgroundChronic Achilles tendon rupture (CATR) is a debilitating condition affecting activities such as walking and jumping. Surgical reconstruction remains preferred for larger defects, with local tendon transfers including the flexor hallucis longus (FHL) and peroneus brevis (PB). However, these techniques carry risks of donor-site morbidity and neurovascular injury, particularly in high-risk patients.ObjectivesThis article describes a novel minimally invasive endoscopic technique and reports 3 cases of CATR reconstruction using peroneus longus (PL) tendon transfer as an alternative.MethodsThis technique employs standard posterolateral and posteromedial hindfoot portals without requiring additional peroneal tendoscopy portals. A small incision is made near the calcaneocuboid joint to perform tenodesis between PB and PL tendons, with the foot in maximum eversion to maximize tendon harvest. The PL tendon is then pulled through the posterolateral portal with the aid of the tag sutures, then passed through a calcaneal tunnel, and secured using an interference screw under fluoroscopic guidance.ResultsThe procedure was performed in 3 patients with complete CATR (2 insertional, 1 noninsertional). At 1-year follow-up, all patients demonstrated clinical improvement in American Orthopaedic Foot & Ankle Society (AOFAS) and Achilles tendon Total Rupture Score (ATRS) measurements, with no gross clinical weakness in ankle eversion or lateral instability. One patient developed localized plantar heel hypoesthesia, while no major neurovascular complications or lateral ankle instability were observed.ConclusionEndoscopic PL transfer was feasible in 3 patients with CATR and was associated with improved short-term clinical scores. This technique may be considered a potential alternative or salvage option when FHL transfer is unsuitable. However, larger comparative studies are needed before definitive conclusions can be made regarding this technique.Levels of Evidence:. - Source: PubMed
Publication date: 2026/08/21
Saleh AhmedHawila Ahmed MaherEltabbaa Ayman Youssef - Appropriate weight gain during pregnancy is essential, as inappropriate weight gain (too much or too little) has complications for both mother and baby, and the ideal amount depends on the mother's body mass index. Balanced nutrition and exercise are the main foundations of a healthy pregnancy, and counseling during this period is an opportunity to promote maternal and fetal health and reduce risks such as preterm birth, gestational diabetes, and hypertension caused by excessive weight gain. This study aims to evaluate the effect of a combined counseling intervention program based on the fogg behavioral model using mobile phone technology (whatsapp or eta) on total gestational weight gain and perinatal outcomes. A randomized controlled trial in qom, iran, will recruit pregnant women to develop a whatsapp platform for individualized, continuous pregnancy weight management services based on the fogg behavior model. All participants will be included in the full analysis set (fas), while the per-protocol set (pps) will consist of women who completed the intervention and provided all outcome data. This study highlights the effectiveness of consultations utilizing the fogg model in managing appropriate weight gain during pregnancy. If the findings confirm that the fogg model-based counseling promotes healthy weight gain in pregnant women, this approach could be implemented during pregnancy to effectively minimize instances of excessive or inadequate weight gain to significantly reduce cases of excessive or insufficient weight gain. - Source: PubMed
Publication date: 2026/07/31
Farid FatemehOmidvar ShabnamAbedi Samakoosh ShayanMohsenzadeh-Ledari FaridehGholamnia-Shirvani ZeinabAdib-Rad HajarBehmanesh FereshtehAhangari RoghayyehKhafri Soraya