CD95 _ FAS
- Known as:
- CD95 _ Fas Cell Surface Death Receptor
- Catalog number:
- MC103
- Product Quantity:
- 100 Tests
- Category:
- -
- Supplier:
- ACR
- Gene target:
- CD95 _ FAS
Related genes to: CD95 _ FAS
- Gene:
- FAS NIH gene
- Name:
- Fas cell surface death receptor
- Previous symbol:
- FAS1, APT1, TNFRSF6
- Synonyms:
- CD95, APO-1
- Chromosome:
- 10q23.31
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-25
- Date modifiied:
- 2019-04-23
Related products to: CD95 _ FAS
Related articles to: CD95 _ FAS
- With the application of high-fat diets (HFDs) leading to increased prevalence of fatty liver in aquaculture, plant extracts such as olive () leaf extract (OLE) have attracted much attention due to their potential bioactive effects. In the present study, five experimental groups were established with HFD (15.5% crude lipid) supplemented with 0.0%, 0.5%, 1.0%, 1.5%, and 2.0% OLE, respectively, and each was fed to three replicate cages containing 20 juvenile (initial body weight: 11.57 ± 0.19 g) per cage. Fish fed HFD supplemented with 1.0% OLE showed significantly increased growth and survival and reduced lipid content in whole fish and triglyceride (TG) and cholesterol contents in serum compared to fish fed HFD ( < 0.05). Analysis of liver gene expression showed that reduced lipid content might be associated with reduced expression of genes associated with lipid synthesis (sterol regulatory element binding protein 1 [], fatty acid synthase [], acetyl-CoA carboxylase [], and diacylgycerol acyltransferase 1 []), and increased expression of genes associated with fatty acid oxidation (peroxisome proliferator-activated receptor α [], hormone-sensitive lipase [], and carnitine palmitoyl transferase-1 []) and lipid transport (CD36 molecule [] and fatty acid binding protein 1 []). Inclusion of OLE not only significantly lowered serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities but also increased activities of serum alkaline phosphatase (AKP) and superoxide dismutase (SOD) and total antioxidant capacity (TAOC), while serum malondialdehyde (MDA) decreased in fish fed HFD with 0.5%-1.0% OLE compared to fish fed HFD ( < 0.05). Additionally, 0.5%-1.0% dietary OLE significantly enhanced the integrity of intestinal morphology, reduced intestinal lipase activity and expression of inflammatory factors (interleukin-1 [] and ), and increased the diversity of intestinal microbiota ( < 0.05). The abundance of beneficial bacterial taxa () was increased, while harmful bacterial taxa () decreased in fed diets with OLE compared to fish fed HFD. The data suggested that dietary OLE (particularly 1.0%) alleviated the negative effects of HFD in , which has highlighted the positive impacts of dietary OLE in fish and provided a new development opportunity for the olive industry through utilization of production waste. - Source: PubMed
Publication date: 2026/08/21
Xie JiayingShen JiajianTocher Douglas RLi YuanyouHao YansenLin ZelingZhan HanLin FanWang ShuqiChen Cuiying - Vitamin D and marine-derived long-chain n-3 (omega-3) fatty acids (FAs) may represent a novel intervention to prevent anemia of inflammation. We report the results of an ancillary study of the larger Vitamin D and Omega-3 Trial (VITAL), which looked at the effect of vitamin D and/or omega-3 FA supplementation on incidence of anemia in midlife and older adults. VITAL is a randomized, double-blinded, placebo-controlled trial, with a 2 × 2 factorial design. We focus on a subcohort of 839 participants without baseline anemia evaluated at the Boston Clinical and Translational Science Center. The primary end point was incidence of anemia (hemoglobin <13 g/dL for men, and <12 g/dL for women measured, at 2 years). The secondary end point was change in hemoglobin from baseline to 2 years. Incidence of anemia in our cohort was 9.3% over 2 years. Neither vitamin D nor omega-3 FAs had significant effect on anemia incidence (odds ratio [OR], 0.94 [95% confidence interval (CI), 0.59-1.51] and 1.31 [95% CI, 0.82-2.09], respectively) or change in hemoglobin from baseline to 2 years. There were no significant differences when stratified by race, sex, body mass index, or baseline vitamin D level. Omega-3 FAs had a statistically significant effect on change in hemoglobin in participants with baseline C-reactive protein >3 mg/L ( interaction = 0.047), whereas vitamin D had an effect in participants with lower than median baseline total fish intake ( interaction = .001). Supplementation with vitamin D or omega-3 FAs, or their combination, did not reduce incidence of anemia in midlife and older adults. The trial was registered at www.ClinicalTrials.gov as #NCT01169259. - Source: PubMed
Publication date: 2025/12/09
Cho Hae LinLi ChunyingManson JoAnn ECook Nancy RLee I-MinBuring Julie EBerliner Nancy - Elevated saturated fatty acids (SFAs) have generally been associated with higher cardiovascular risk, whereas emerging evidence suggests that long- and very-long-chain SFAs (LVLSFAs) may be inversely associated with cardiometabolic outcomes. - Source: PubMed
Publication date: 2026/08/05
Ramezankhani AzraHadaegh PartoAbiri BehnazHadaegh Farzad - In natural environments, animals must detect behaviorally relevant odors despite variability in both odor mixture composition and stimulus intensity. Although mice can identify salient odors embedded in complex mixtures, how target concentration and background complexity jointly constrain discrimination remains unclear. We trained mice in a two-alternative forced choice task to identify target odors embedded in mixtures containing up to 16 background components. After performance stabilized, we systematically varied target odor concentration. Discrimination accuracy declined with decreasing target concentration but showed little additional dependence on background complexity. Using a biophysically grounded model of olfactory bulb glomerular responses, we show that linear decoding reproduces behavioral performance when intrinsic neural noise dominates over background-driven variability. Manifold capacity analysis revealed that neural representations remain efficiently structured for odor discrimination despite variation in background complexity. These results define a noise-limited regime of olfactory discrimination in which target detectability is primarily constrained by neural sensitivity rather than background interference. - Source: PubMed
Publication date: 2026/08/20
McCalmon HannahCai GeorgeTsibouris ConstantineHamou NoéHoskins JoPashakhanloo FarhadChung SueYeonKapoor VikrantMurthy Venkatesh N - Fatty acids (FAs) play critical neurodevelopmental roles, yet associations with executive function among children affected by perinatal HIV remain poorly characterized. This prospective cohort study examined associations between serum FAs and caregiver-reported executive function and evaluated effect modification by perinatal HIV status among 6-10-year-old Ugandan children who had perinatal HIV infection (CPHIV; n = 84), were HIV exposed but uninfected (CHEU; n = 78), or were HIV unexposed and uninfected (CHUU; n = 81). Serum FAs were measured at enrollment, and executive dysfunction was assessed at enrollment, 6, and 12 months (Executive Functioning Index (EFI) and Global Executive Composite (GEC)). Multivariable linear mixed models estimated overall and HIV-specific mean differences (MDs) and 95% confidence intervals (CIs) in executive dysfunction z-scores by FA tertiles. Moderate versus low arachidonic acid (MD [95% CI] EFI: -0.40 [-0.71, -0.09]; GEC: -0.30 [-0.58, -0.03]) and highly unsaturated FAs (HUFAs; EFI: -0.41 [-0.72, -0.11]) associated with lower executive dysfunction. Among CPHIV, high Mead acid (20:3 (n-9)) associated with higher executive dysfunction (EFI: 0.56 [0.11, 1.01]). Among CHEU, lower executive function was associated with high docosatetraenoic acid (EFI: -0.93 [-1.71, -0.15]) and docosahexaenoic acid (GEC: -0.78 [-1.26, -0.31]). These results showed that higher HUFAs associated with better executive function, particularly among CHEU, supporting further nutritional intervention research for children affected by perinatal HIV. - Source: PubMed
Cardino Vanessa NGiordani BrunoSikorskii AllaZalwango Sarah KFenton Jenifer IEzeamama Amara E