CD95 _ FAS
- Known as:
- CD95 _ Fas Cell Surface Death Receptor
- Catalog number:
- GTX82928
- Product Quantity:
- 200 µg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- CD95 _ FAS
Related genes to: CD95 _ FAS
- Gene:
- FAS NIH gene
- Name:
- Fas cell surface death receptor
- Previous symbol:
- FAS1, APT1, TNFRSF6
- Synonyms:
- CD95, APO-1
- Chromosome:
- 10q23.31
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-25
- Date modifiied:
- 2019-04-23
Related products to: CD95 _ FAS
Related articles to: CD95 _ FAS
- Bovine viral diarrhea virus (BVDV), one of the most important viral pathogens in cattle, causes serious economic losses due to immunosuppression and persistent infections. Previous studies have shown a tight connection between virus infection and lipid metabolism, particularly in the formation and degradation of lipid droplets (LDs). However, the pathogenic mechanism of BVDV infection and the molecular mechanisms by which viral proteins reprogram lipid metabolism remain unclear. We found that BVDV increased cellular LD accumulation by enhancing the production of new lipids, accelerating exogenous fatty acid uptake, and elevating diacylglycerol acyltransferase (DGAT)-dependent esterification of fatty acids (FAs). The generated LDs subsequently release free fatty acids (FFAs) via adipose triglyceride lipase/hormone-sensitive lipase (ATGL/HSL)-dependent lipolysis. This lipolysis-dependent release of FFAs is accelerated and transferred to mitochondria for oxidation by increasing contact between LDs and mitochondria, thereby promoting viral replication. Furthermore, BVDV core protein targets the surface of LDs, increasing and recruiting fatty acid synthase (FASN) and ATGL to promote LD mobilization. Meanwhile, the core protein interacts with mitochondria, linking mitochondria to LDs and facilitating the release of FAs for efficient fatty acid oxidation. Collectively, this study demonstrates that the BVDV core protein regulates cellular lipid metabolism to support BVDV replication, contributing to understanding the pathogenetic mechanisms by which BVDV interacts with host cells. - Source: PubMed
Publication date: 2026/09/19
Xiong XiaoranLiu YiZhu YaohongWang JiufengYang Guiyan - Stimulator of interferon genes (STING) not only plays an important role in innate immunity, but also acts as a regulator of lipid metabolism in insects. AMP-activated protein kinase (AMPK) serves as a crucial cellular energy sensor that regulates lipid homeostasis. However, the interplay between STING and AMPK remains largely unknown in insects. In this study, STING was cloned from Tribolium castaneum. Spatial-temporal expression analysis revealed that TcSTING was highly expressed in the fat body and in 7-day-old adult females, respectively. Knockdown of TcSTING significantly reduced TAG levels, decreased neutral-lipid storage in fat body lipid droplets, and lowered FAS activity concomitantly with the downregulation of genes encoding sterol regulatory element binding protein (SREBP) and fatty acid synthase (FAS1-5) in 15-day-old larvae and 2-day-old females. Conversely, knockdown of TcAMPK in 2-day-old females significantly increased the levels of TAG and neutral-lipid storage in fat body as well as FAS activity accompanied by the upregulation of TcSREBP and FAS1-5. Mechanistically, knockdown of TcSTING activated AMPK by inactivating TBK1, leading to the upregulation of phosphorylation level of acetyl-CoA carboxylase (ACC) and inhibition of the transcription of TcSREBP, whereas dsTcAMPK treatment suppressed ACC phosphorylation and activated the transcription of TcSREBP. These results demonstrate that TcSTING modulates lipid metabolism via phosphorylation regulation of AMPK, thereby altering the TAG storage. - Source: PubMed
Publication date: 2026/09/19
Li HaiWang ZhichaoZheng QunWei JiapingQian KunZhang HainanWang Jianjun - Fusaric acid (FA) is a mycotoxin produced by multiple Fusarium species and is a frequent contaminant of maize and other cereal grains. Its toxicological effects are closely tied to its structural characteristics, particularly its weak acid nature and strong metal-chelating ability, with iron being a critical target. By disrupting iron homeostasis, FA contributes to oxidative stress by enhancing reactive oxygen species (ROS) production and modulating antioxidant defence pathways. Furthermore, FA's interaction with iron positions it as a potential regulator of ferritinophagy and ferroptosis, two interconnected processes that link iron metabolism to cellular survival and death. Although FA has been associated with other cellular pathways, its precise role in iron-dependent pathways remains insufficiently defined. This review seeks to consolidate current knowledge on FA, emphasising its iron-chelating properties and their impact on iron-dependent mechanisms, including oxidative stress, ferritinophagy, and ferroptosis. - Source: PubMed
Publication date: 2026/09/19
Govender Anthia CGhazi Terisha - Human milk is the gold standard for infant nutrition. This study aimed to develop a camel milk fat-based human milk lipid mimetic whose fatty acid (FA) composition, structural properties, and digestibility more closely resemble those of human milk fat than conventional vegetable oil-based formulas. Camel milk (CM) fat was physically blended with sunflower, rapeseed, palm kernel, fish oils, and 1,3-dioleoyl-2-palmitoylglycerol using a computational optimization model to approximate the total and FA profiles of Egyptian human milk. The resulting formulation, together with three commercial formulas and human milk, was compared for total and FAs by gas chromatography, similarity indices, FTIR, DSC characteristics, and dynamic gastrointestinal digestion, including lipolysis degree and free FA release. IFCM contained 29 detectable fatty acids, matching human milk and exceeding commercial formulas ( ≤ 19), and reduced fatty acid mismatches with human milk to 11 vs. 12-19 in commercial products. Total saturated fatty acids reached 50.99%, and sn-2 palmitic acid 34.76%, closer to human milk than in commercial formulas. Intestinal lipolysis at 120 min was 66.47% for IFCM vs. 69.93% for human milk and 60.28%-65.43% for commercial formulas, while FTIR and DSC profiles of IFCM aligned more closely with human milk than with vegetable oil-based formulas. Combining CM fat with selected oils resulted in an infant formula with improved compositional and structural resemblance to human milk fat, as well as enhanced lipid digestion, compared to conventional formulas. IFCM represents a promising candidate human milk fat mimetic, warranting evaluation of its effects on infant growth, mineral absorption, and metabolic outcomes. - Source: PubMed
Publication date: 2026/09/04
Bakry Ibrahim AWei WeiLi NingAbouzid MohamedWang XingguoGolshany HazemElbarbary AbdelazizNafea Alaa EGohary Amal - The use of autologous growth factors, such as those contained in Hypoxia-Preconditioned Serum (HPS) and Platelet-Rich Plasma (PRP), represents a promising strategy to enhance regenerative processes in injured nerves. As an initial study, we investigated the effects of these secretomes on the neuroblastoma cell line N2a. - Source: PubMed
Publication date: 2026/09/04
Jiang JunSafa DonyaKnoedler SamuelAltammar JannatFalkner FlorianHanschen MarcKükrek HaydarDornseifer UlfSchilling Arndt FMachens Hans-GüntherMoog Philipp