CD95 _ FAS
- Known as:
- CD95 _ Fas Cell Surface Death Receptor
- Catalog number:
- GTX82928
- Product Quantity:
- 200 µg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- CD95 _ FAS
Related genes to: CD95 _ FAS
- Gene:
- FAS NIH gene
- Name:
- Fas cell surface death receptor
- Previous symbol:
- FAS1, APT1, TNFRSF6
- Synonyms:
- CD95, APO-1
- Chromosome:
- 10q23.31
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-25
- Date modifiied:
- 2019-04-23
Related products to: CD95 _ FAS
Related articles to: CD95 _ FAS
- Acute respiratory failure (ARF) requiring invasive mechanical ventilation affects approximately 1.5 million adults in the United States annually. Whereas ARDS is well characterized, non-ARDS ARF-comprising most patients who are mechanically ventilated-lacks systematic characterization of clinical features, biological profiles, and long-term outcomes. - Source: PubMed
Publication date: 2026/05/07
Kitsios Georgios DBain William GEvankovich John WPrendergast NiallHensley MatthewSuber TomekaInman KyleSchaefer CaitlinSaul MelissaChen XiaopingHaque MenaalLee JanetRizzo AliciaQin ShulinZhang YingzeMorris AlisonCruz Charles DelaNouraie Seyed MehdiMcVerry Bryan JShah Faraaz A - Heart-type fatty acid-binding protein (H-FABP), a principal intracellular transporter of long-chain fatty acids (FAs), has been investigated as an early diagnostic biomarker for acute myocardial infarction (MI) and acute coronary syndrome. However, evidence regarding its associations with long-term risk of cardiac events and potential interaction with omega-3 FAs remains scarce. Therefore, we aimed to investigate these associations in the general population. - Source: PubMed
Publication date: 2026/10/01
Lyu Jie-QiongQian Yu-WenXu ZiruiLiu Zhong-YueFang FeiMiao Meng-YuanQin Li-QiangSong Cheng-LinWang Hai-PengChen Guo-Chong - PTPN22, a protein tyrosine phosphatase (PTP) family member, has recently emerged as an intracellular regulator in adaptive immune cells. However, its function in natural killer (NK) cells remains unclear despite its high expression in innate immune cells. - Source: PubMed
Publication date: 2026/10/01
Uong Tung Nguyen ThanhYoon MeesunNguyen Nhat Phuoc Nguong MinhLee MijeongKoh Seung KwonJeong Jae-UkKim Yong-HyubCho Duck - Fas-associated protein with death domain (FADD) is a crucial adaptor protein in the insect Immune Deficiency (IMD) signaling pathway. Although its role in regulating antimicrobial peptide (AMP) synthesis has been established in Drosophila, its function in Ostrinia furnacalis remains unclear. In this study, we identified a FADD (designated Of-FADD) with a full-length cDNA of 971 bp, containing a 666 bp open reading frame encoding a 221-residue protein with a characteristic death effector domain (DED) and a death domain (DD). Expression profiling showed the highest transcript levels in fifth-instar larvae, with significant enrichment in the midgut and hemocytes. Bacterial infection experiments demonstrated that both Escherichia coli and Staphylococcus aureus significantly induced Of-FADD expression, with peak upregulation observed at 12 h and 24 h post-infection, respectively. Concurrently, the expression of Relish and AMP genes was also significantly upregulated. RNA interference (RNAi) revealed that knockdown of Of-FADD significantly downregulated the expression of Relish and AMP genes. Following RNAi and subsequent bacterial infection, Of-FADD expression exhibited a compensatory response. Subcellular localization analysis indicated that Of-FADD is distributed in the cytoplasm. Of-FADD can form oligomers but does not assemble into amyloid fibril structures independently under the tested conditions. This study provides transcript-level evidence in a lepidopteran pest that Of-FADD positively modulates AMP-mediated immune responses, likely via the IMD signaling pathway, and that its signal transduction mechanism does not rely on amyloid fibril formation under our experimental conditions. These findings contribute to our understanding of immune mechanisms in lepidopteran pests and offer potential molecular targets for developing novel pest control strategies. - Source: PubMed
Publication date: 2026/10/01
Bi HonglunLiu YulinGuo WenlongQi YanzheDong MengyaoSun YuanHan ZhaoyangLi ShuzhongFeng Congjing - The effects of multi-enzyme supplementation (ES) in diets with 10% ahiflower seed (AS) or presscake (APC) on growth, nutrient digestibility, intestinal morphology, gizzard weight, bone characteristics, and meat fatty acids (FAs) in broiler chickens were evaluated. One-day-old Ross 308 broiler chicks were housed 15/pen and assigned to six diets in a 3 × 2 factorial arrangement, including a corn-soybean control (CON), CON+10%AS, and CON+10%APC, with or without ES, for 35d, in a randomized complete block design with six pens/treatment. Overall, body weight (BW) and BW gain (BWG) were reduced by 10%AS and 10%APC (P = 0.0001), while only 10%AS reduced feed intake. Without ES, 10%APC increased FCR, but with ES, no negative effect of APC was observed. Compared to CON, 10%AS increased the duodenal villus height (VH; P = 0.0064), jejunal VH (P = 0.0488), and jejunal villus height: crypt depth (VH:CD; P = 0.0284), while 10%APC increased VH:CD in the ileum (P = 0.0332). Phosphorus digestibility was reduced by 10%AS (P = 0.0381) and ES (P = 0.0396), whereas calcium digestibility was unaffected by diet, ES, or interaction. Crude protein digestibility showed a diet × ES interaction (P = 0.0211), where lower value was observed for 10%AS than CON, only when enzyme was supplemented. Gizzard weight was increased in birds fed 10%APC compared with CON (P = 0.0020), with no ES effect. The bone breaking strength of the right tibia was higher in 10%AS than in 10%APC (P = 0.0211). Compared to CON, tibia weights were lower in 10%APC (P = 0.0207 and 0.0491, for right and left tibia, respectively), with no ES effect. In the breast meat, 10%AS increased stearidonic acid (SDA; P = 0.0467) and improved omega-6:omega-3 (P < 0.0001). In the thigh meat, 10%AS increased (P < 0.001) the contents of SDA, gamma linolenic acid, and total polyunsaturated FAs, compared to CON. Both 10%AS and 10%APC increased (P < 0.0001) the contents of alpha-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, and total omega 3 FAs in the thigh meat, while improving the omega-6:omega-3, compared to CON (P < 0.0001). There was a significant interaction (P = 0.0002) between ES and diet in Omega-6:Omega-3, with a better ratio in CON+ES than CON-ES. In conclusion, though 10%AS and 10%APC reduced BW and BWG, they increased the concentrations of polyunsaturated FAs in the thigh meat, with 10% AS also increasing SDA concentration in the breast meat and increasing right tibia breaking strength. While 10%AS improved intestinal morphology in the duodenum and jejunum, 10%APC improved it only in the ileum. - Source: PubMed
Publication date: 2026/09/28
Lawrence-Azua Ann SewueseOgory Roseline OAdewole Deborah