CD95 _ FAS
- Known as:
- CD95 _ Fas Cell Surface Death Receptor
- Catalog number:
- GTX82928
- Product Quantity:
- 200 µg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- CD95 _ FAS
Related genes to: CD95 _ FAS
- Gene:
- FAS NIH gene
- Name:
- Fas cell surface death receptor
- Previous symbol:
- FAS1, APT1, TNFRSF6
- Synonyms:
- CD95, APO-1
- Chromosome:
- 10q23.31
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-25
- Date modifiied:
- 2019-04-23
Related products to: CD95 _ FAS
Related articles to: CD95 _ FAS
- Pulmonary arterial hypertension (PAH) is a fatal complication of systemic lupus erythematosus (SLE), yet the mechanisms linking autoimmune dysregulation to progressive pulmonary vascular remodeling are poorly defined, leading to inadequate therapies. This study investigated BAFF (B-cell activating factor), a key cytokine in SLE, as a potential driver of SLE-PAH pathogenesis. - Source: PubMed
Publication date: 2026/09/24
Jiang XuehanMa LeyaoLi YutongDeng XiaoyueYuan QizhiZhang JunweiHu HuiyuanGao YidanDong XingbeiTao YuhuanZhang WenjiaQian JunyanXing YanjiangHu YufeiZhang HongZhao JiuliangWang QianZeng XiaofengYang YuanhuaSong WanluLi MengtaoYang PeiranWang Chen - Lipases (E.C. 3.1.1.3) are enzymes that catalyze the hydrolysis of triacylglycerols (TAGs) into glycerol and fatty acids (FAs), making them essential for various industrial applications, including food processing, detergents, pharmaceuticals, and biofuels. This chapter focuses on methods used to assess true lipase activity, specifically those for measuring the release of FAs from long-chain triglycerides with varying saturation levels (e.g., C8:0, C10:0, C12:0, C14:0, C16:0, C18:0, C18:1), as well as complex, standardized lipid substrates such as oils, mayonnaise, lipstick, sebum, beef fat, and butterfat. These are assessed using the non-esterified free fatty acid (NEFA/FFA) colorimetric assay. The combined use of triglycerides, standardized test materials (e.g., stained fabrics), and the NEFA assay provides a more practical and realistic evaluation of true lipase activity, particularly relevant for industrial applications such as detergents. - Source: PubMed
Vidal PaulaAlmendral DavidFernandez-Lopez LauraV Cervantes FadiaMolina-Espeja PatriciaBargiela RafaelFerrer Manuel - Mechanosensing enables cells to perceive and interpret their mechanical microenvironment, including forces, stiffness and topography. Although focal adhesions (FAs) are central to this process, their structural adaptation to mechanical stimuli remains poorly understood. Here, we uncover FA tilting - the inclination of the FA plane relative to the substrate - as a mechanically regulated architectural feature. Using reverse cell imprinting and atomic force microscopy, we reveal a strong inverse correlation between FA tilting angle and substrate stiffness. A two-dimensional clutch model shows that tilting emerges from force distribution across the FA-substrate interface and contributes to cell mechanosensing. By engineering rigid substrates with defined curvatures, we impose specific tilting angles independently of stiffness and modulate the cellular mechanostate, revealing a curvature-stiffness mechanical equivalence principle. This enables the construction of a correlation map linking curvature values to equivalent stiffness levels.Together, our results identify FA tilting as a geometrical and mechanical transducer and a powerful design parameter for instructive biomaterials in physio-pathological tissue engineering. - Source: PubMed
Publication date: 2026/08/25
Frascogna CrescenzoPanzetta ValeriaMollo ValentinaMarotta RaffaeleStrano SalvatoreFusco SabatoNetti Paolo A - CD30-positive large-cell proliferations arising in patients with mycosis fungoides can be diagnostically challenging, particularly when they show variable T-cell receptor expression or gamma/delta (γδ) phenotype. We present two cases of mycosis fungoides (MF) with CD30-positive large cell transformation (LCT)/progression exhibiting γδ T-cell phenotypic evolution. Case 1, a 50-year-old woman, initially presented with hyperpigmented patches and papulonodular lesions showing epidermotropic small-cell MF alongside dermal CD30-positive large cells with a γδ phenotype. Over ten years, she developed recurrent cutaneous and eventually nodal disease with phenotypic shifts between γδ and αβ expression, while molecular studies confirmed a single clonal process across all biopsies. Potentially pathogenic variants in FAS and CD70 were identified. Case 2, a 72-year-old man with longstanding MF, developed CD30-positive LCT initially with an αβ phenotype that subsequently acquired γδ expression and DUSP22 rearrangement. Oncoscan microarray revealed shared copy-number alterations including CDKN2A/B loss across temporally distinct biopsies, and sequencing identified KMT2C and TET1 variants. Both cases illustrate that MF can exhibit dynamic T-cell receptor phenotypic evolution, posing significant diagnostic challenges with lymphomatoid papulosis and primary cutaneous γδ T-cell lymphoma. Clonal identity confirmation through molecular studies is essential for accurate classification. - Source: PubMed
Publication date: 2026/09/23
Chaudhary SahilAdekunle FolashadeRoberts NathanCropley ThomasMarchi EnricaFan JinboObiorah Ifeyinwa E - Acute infected wounds remain a major clinical challenge owing to persistent inflammation, oxidative stress, and impaired angiogenesis. While natural phenolic compounds, like ferulic acid (FA), have antioxidant properties, their role in coordinating wound repair across immune and vascular cells remains unclear. - Source: PubMed
Publication date: 2026/09/16
Amona Fructueux ModesteChen XiaohanYang ShiqingZhang ZhuoxuanLiu ZiluWang YuenanChen WenxinZhou RongChen XiPang YipengXu JiabinFang Xingtang