CDH5 _ Cadherin_5 _ CD144 Antibody
- Known as:
- CDH5 _ Cadherin_5 _ CD144 Antibody
- Catalog number:
- 50192-RP01
- Product Quantity:
- 200
- Category:
- -
- Supplier:
- Smart Serology
- Gene target:
- CDH5 _ Cadherin_5 CD144 Antibody
Related genes to: CDH5 _ Cadherin_5 _ CD144 Antibody
- Gene:
- CDH5 NIH gene
- Name:
- cadherin 5
- Previous symbol:
- -
- Synonyms:
- 7B4, CD144
- Chromosome:
- 16q21
- Locus Type:
- gene with protein product
- Date approved:
- 1992-11-20
- Date modifiied:
- 2016-10-05
Related products to: CDH5 _ Cadherin_5 _ CD144 Antibody
Related articles to: CDH5 _ Cadherin_5 _ CD144 Antibody
- Lagopsis supina is a traditional Chinese medicinal herb used for activating blood circulation and nourishing the blood. This study aims to investigate the pro-angiogenic constituents of L. supina and their mechanisms of their action. 30 compounds derived from the active fraction LS-D (L. supina 60% ethanol-water extract) were screened, of which 15 showed angiogenesis-promoting activity, were screened in a PTK787-induced vascular injury zebrafish model. The active constituents were primarily phenolic acids and phenylpropanoids, among which compounds LS21 (vanillic acid) and LS22 (syringic acid) exhibited the most potent pro-angiogenic effects. These constituents (LS21 and LS22) were selected for further investigation of mechanisms of promoting angiogenesis. Transcriptomic analysis followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment revealed differentially expressed genes and predicted involved pathways. Molecular docking simulated interactions between compounds and key pathway proteins, and RT-qPCR validated gene expression patterns. Mechanistic studies integrating transcriptomics, molecular docking, and RT-qPCR revealed that both LS21 and LS22 downregulated immune-related cell adhesion molecules, while upregulating cdh5 and pecam1a. Additionally, LS21 specifically downregulated the signaling molecules smad2 and smad3a, and upregulated the transcriptional corepressors skila and ncor1. In contrast, LS22 downregulated extracellular matrix-related adhesion molecules and itga2b, while upregulating thbs1a and integrin itgb3b. In conclusion, the L. supina constituents LS21 and LS22 that are primarily phenolic acids and phenylpropanoids, exert their angiogenesis-promoting effects mainly via modulating cell adhesion and suppressing TGF-β signaling pathway. - Source: PubMed
Publication date: 2026/07/06
Yu JiahaoWang XiaoyiJia LiyanFu LuluHe JunweiZhang ShanshanHe QiuxiaLiu KechunLi XiaobinLi Na - Given the high relevance of human cardiac valve disease, recent research aims to differentiate human induced pluripotent stem cells (hiPSCs) into valve endothelial-like cells (VELCs) and, through endothelial-to-mesenchymal transition (EndMT), into valve interstitial-like cells (VILCs). - Source: PubMed
Publication date: 2026/07/02
Farzaneh ZBrückner AFleischmann B KRieck S - Tumor-associated endothelial cells (TAECs) are integral components of the clear cell renal cell carcinoma (ccRCC) microenvironment, but their gene expression-based prognostic value and functional relevance remain to be defined. - Source: PubMed
Publication date: 2026/07/02
Liu QingCao WenxingHao Zhouhua - Obesity-induced insulin resistance contributes to metabolic dysfunction and type 2 diabetes, yet the endothelial mechanisms involved remain incompletely understood. Here, we identify endothelial natriuretic peptide receptor C (NPR-C) as a key regulator of insulin transport and insulin sensitivity. NPR-C expression was increased in endothelial cells from adipose tissue and skeletal muscle of obese mice. Endothelial-specific deletion of NPR-C improved insulin sensitivity, whereas endothelial NPR-C overexpression aggravated insulin resistance, as demonstrated by glucose tolerance, insulin tolerance, and hyperinsulinemic-euglycemic clamp. Mechanistically, NPR-C impaired insulin uptake and transendothelial transport by reducing insulin receptor (IR) membrane localization and altering intracellular trafficking. NPR-C directly interacted with Caveolin-1 and promoted Tyr14 phosphorylation-dependent K48-linked ubiquitination and proteasomal degradation of Caveolin-1, disrupting caveolae function and impairing IR trafficking. Importantly, Cdh5 promoter-driven adeno-associated virus-mediated NPR-C knockdown improved insulin sensitivity in mice with established obesity. Together, these findings identify endothelial NPR-C as a regulator of Caveolin-1 stability and IR trafficking and suggest NPR-C as a potential therapeutic target for obesity-associated insulin resistance. - Source: PubMed
Publication date: 2026/06/30
Xu Zi-QiYu Xin-YiWei Jin-QiuDeng Qian-WanZhai Wen-HuiRong Wu-WeiLi Meng-YaoZhang Qi-RongGao Ping-JinLi Xiao-DongWang Ji-Guang - Oral squamous cell carcinoma (OSCC) is characterized by high aggressiveness. This study aims to elucidate the role of NDRG1 in the evolutionary heterogeneity and spatial microenvironmental remodelling of OSCC. By integrating bulk transcriptomics, single-cell RNA sequencing (scRNA-seq), and spatial transcriptomics (ST), complemented by in vivo and in vitro functional assays, we systematically explored the regulatory logic of the MSTRG.47889/miR-1299/NDRG1 axis. The MSTRG.47889/miR-1299/NDRG1 ceRNA regulatory axis was identified and validated, demonstrating its significant role in promoting OSCC proliferation and invasion while impairing cellular adhesion. Single-cell analysis revealed a significant expansion of the NDRG1-high subpopulation in tumour tissues, which drives cellular evolution along a pseudotime trajectory toward a partial epithelial-mesenchymal transition (p-EMT) and a high glycolytic state. Spatial transcriptomics analysis revealed that NDRG1 is highly expressed within 'hypoxia-metabolic' niches. Our integrative analysis suggests that these regions may coordinate with endothelial cells, highlighting a potential role for the ANGPTL4-CDH5 signalling axis in promoting a proangiogenic microenvironment. These findings provide preliminary insights into how NDRG1 serves as a pivotal regulator driving p-EMT and coordinating niche remodelling. NDRG1 serves as a pivotal regulator driving p-EMT and proangiogenic niche remodelling, representing a potential novel target for the diagnosis and treatment of OSCC. - Source: PubMed
Publication date: 2026/06/27
Feng LeiOu YiTian LinqingJiang WenjieZhang MinSheng Xun