TIMD3 _ TIM3 _ HAVCR2 Antibody
- Known as:
- TIMD3 _ TIM3 _ HAVCR2 Antibody
- Catalog number:
- 10390-MM04
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Smart Serology
- Gene target:
- TIMD3 _ TIM3 HAVCR2 Antibody
Related genes to: TIMD3 _ TIM3 _ HAVCR2 Antibody
- Gene:
- HAVCR2 NIH gene
- Name:
- hepatitis A virus cellular receptor 2
- Previous symbol:
- -
- Synonyms:
- Tim-3, TIM3, FLJ14428, TIMD3, CD366
- Chromosome:
- 5q33.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-12-04
- Date modifiied:
- 2018-06-27
Related products to: TIMD3 _ TIM3 _ HAVCR2 Antibody
Related articles to: TIMD3 _ TIM3 _ HAVCR2 Antibody
- The Warburg effect is one of the most important metabolic alterations in tumor cells. Hypoxia-inducible factor 1-alpha (HIF-1α) targets a broad range of gene promoters in normoxic and hypoxic conditions in cancers. Herein, we investigate the effects of HIF-1α inhibition on cell viability and messenger RNA (mRNA) expression of immune checkpoint receptors (ICRs) in acute myeloid leukemia cell lines. K-562 and HL-60 cells were treated with silibinin as an HIF-1α inhibitor. Cell viability was evaluated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, followed by quantification of V-domain immunoglobulin suppressor of T-cell activation (VISTA), T-cell immunoglobulin and mucin domain 3 (TIM3), and Galectin-9 mRNA expression via quantitative reverse-transcription polymerase chain reaction (qRT-PCR). The expression levels of VISTA, TIM3, and Galectin-9 decreased after silibinin treatment within both K-562 and HL-60 cells; however, there were some disparities in gene expression levels between the two cell lines. VISTA and TIM3 expression were reduced by approximately 70% in K-562 at the 40% inhibitory concentration (IC40), while no significant changes were observed in HL-60 cells. Conversely, Galectin-9 expression was decreased significantly at both the IC30 and IC40 in HL-60, whereas it was almost consistent in K-562 cells. Collectively, we have shown that silibinin could serve as a cytotoxic small-molecule inhibitor and regulate the expression of ICRs, potentially counteracting T-cell exhaustion. - Source: PubMed
Publication date: 2026/08/12
Kahrizi AmirAkbar ArminNajafi AhmadAsgarian-Omran HosseinValadan RezaMehri MohammadTehrani Mohsen - Immune checkpoint receptors (ICRs) are widely used as markers of T-cell exhaustion, yet their interpretation remains context-dependent and is poorly described in γδ T cells. Here, we investigated the dynamics, functional impact, and differentiation-associated distribution of ICRs across human γδ and αβ T-cell subsets. - Source: PubMed
Publication date: 2026/09/30
Corsale Anna MariaDi Simone MartaCerapio Juan PabloLo Presti ElenaPizzolato GabrieleAvellone ClaudiaDieli CostanzaMarchiafava SalvatoreDi Paola LauraDieli FrancescoMeraviglia Serena - RNA sequencing (RNA-seq) analysis revealed transcriptional features indicative of sustained immunosuppression within regulatory T cells (Tregs) isolated from atherosclerotic tissues, highlighting the critical contribution of immune checkpoint (ICP) receptor-ligand interactions to atherosclerosis progression. To comprehensively characterize the roles of ICP signaling in this context, we integrated transcriptomic profiling, quantitative RT-PCR, and flow cytometry analysis, yielding several key findings: (1) Multiomics integration revealed global transcriptomic alterations in ICP receptors and ligands across diverse tissues, immune cell types, and disease stages in both human and murine models of atherosclerosis; (2) Several ICP components demonstrated functional relevance, including dual-function ligand CD155 (PVR); inhibitory ligands Lgals3 and Itgb1; stimulatory ligands Tnfrsf9 and CD48; and inhibitory receptors Havcr2 and Lair1. These molecules act as microenvironmental sensors, dynamically responding to atherosclerotic cues; (3) Experimental validation confirmed upregulation of the CD155-TIGIT axis within immune cells of atherosclerotic plaques. Notably, CD155 expression positively correlated with CD206 expression in both CD11bCD11c and CD11bCD11c cells, irrespective of tissue context; and (4) The CD206+ macrophages/DCs-CD155-TIGIT Treg axis emerged as a potential ICP-mediated pathway that confers immunoregulatory protection against atherosclerosis progression. Collectively, these findings uncover novel immunomodulatory roles for ICP ligands in atherosclerosis, expanding their known functions beyond adaptive immune regulation to include modulation of innate immune responses within atherosclerotic lesions. - Source: PubMed
Publication date: 2026/09/17
Shao YingSaaoud FatmaIssa Mohammed BenXu KemanLu YifanHung Shih-YuLiu JuanjuanYuan BoWei JunchengWu ShengMohsin SadiaZhou ZhengjieKosmider BeataMartinez LaiselVazquez-Padron RobertoWang HongYang Xiaofeng - Panniculitis in adolescents often poses a diagnostic challenge for physicians. We report an adolescent girl presenting with recurrent steroid-responsive lymphocytic septal panniculitis, genital ulcer, and constitutional symptoms, later complicated by macrophage activation syndrome and steatohepatitis. Extensive evaluation excluded infectious, autoimmune, and malignant causes. Histopathology revealed septal panniculitis without vasculitis or atypical lymphoid cells. Whole-exome sequencing identified a heterozygous variant (c.595A>G; p.Thr199Ala) and a homozygous variant (c.290T>C; p.Ile97Thr); the latter has not been reported in a homozygous state in existing genomic databases and is predicted to be deleterious. The coexistence of panniculitis, haemophagocytic lymphohistiocytosis (HLH)-like manifestations, and histologically lymphocytic rather than neutrophilic infiltrates suggests a distinct panniculitis-HLH overlap syndrome associated with the mutation, which does not fit within the subcutaneous panniculitis-like T-cell lymphoma spectrum. A potential contribution (gene dosage effect) from the heterozygous mutation was uncertain, as parental testing was not feasible. The patient achieved sustained remission on corticosteroids and tacrolimus. This case broadens the phenotypic spectrum of -associated immune dysregulation and documents a novel homozygous variant (p.Ile97Thr), underscoring the importance of comprehensive genetic evaluation in patients with unexplained recurrent panniculitis. - Source: PubMed
Publication date: 2026/09/15
Mukherjee SayanSahu Rajat KChandra Nidhish MDhakad UrmilaKumar Puneet - Mechanical ventilation is associated with acute and long-term cognitive dysfunction, yet the molecular pathways linking ventilator-induced lung injury (VILI) to brain injury remain poorly characterized. We previously demonstrated that peripheral IL-6 signaling mediates delirium-like phenotypes in a murine VILI model. Here, we use unbiased aptamer-based proteomics to determine whether this model exhibits proteomic signatures consistent with neurodegenerative processes in the brain and plasma. - Source: PubMed
Publication date: 2026/09/29
Winzey Kevin DGuzman SamuelYang EdwardMoreira DebbieWang XingyuGu XuesongDillon Simon TEly E WesleyKarumanchi S AnanthLibermann Towia ALahiri Shouri