Granzyme B _ GZMB Antibody (Antigen Affinity Purified)
- Known as:
- Granzyme B _ GZMB Antibody (Antigen Affinity Purified)
- Catalog number:
- 10345-RP04
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Smart Serology
- Gene target:
- Granzyme _ GZMB Antibody (Antigen Affinity Purified)
Related genes to: Granzyme B _ GZMB Antibody (Antigen Affinity Purified)
- Gene:
- GZMB NIH gene
- Name:
- granzyme B
- Previous symbol:
- CTLA1, CSPB
- Synonyms:
- CCPI, CGL-1, CSP-B, CGL1, CTSGL1, HLP, SECT
- Chromosome:
- 14q12
- Locus Type:
- gene with protein product
- Date approved:
- 1989-05-12
- Date modifiied:
- 2016-10-05
Related products to: Granzyme B _ GZMB Antibody (Antigen Affinity Purified)
Related articles to: Granzyme B _ GZMB Antibody (Antigen Affinity Purified)
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Yang ZongqiangYue XuefengLiu QiangGu ZhanguiMa LongTao ZhenyongWang KunWei DaihaoHuang RuiHu JinNiu NingkuiShi Jiandang - Huayu Wan (HYW), a Traditional Chinese Medicine (TCM) formulation widely used in the clinical treatment of cancer, has demonstrated anti-tumor activity and augments chemotherapy efficacy by improving intratumoral drug delivery in non-small cell lung cancer. However, its efficacy and role in enhancing the response to immune checkpoint inhibitors (ICIs) for the treatment of triple-negative breast cancer (TNBC) remain unclear. - Source: PubMed
Publication date: 2026/05/19
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Publication date: 2026/06/03
Li XinLiu WeihongZhang YucuiXiang GuohanBi QianyuLin XinLiu YangBa TejinKong LiLiu YangHao Hao - Plant pathogenic fungi pose a significant threat to global food security. Hence, discovering targeted (bio)chemical methods to combat plant diseases is a critical research avenue. Recent work has implicated copper radical oxidases (CROs) from Auxiliary Activity Family 5 (AA5) in fungal morphogenesis and pathogenesis, including in appressorium penetration by foliar phytopathogens in the genera and . We identified orthologous AA5-encoding genes in species; however, it was not clear that the functions of the corresponding CROs would be conserved in these vascular wilt pathogens. Using JR2 as an exemplar, recombinant protein production and detailed enzyme kinetic analyses revealed predominant aryl-alcohol oxidase activity of the AA5 subfamily 2 (AA5_2) homolog, and predominant aldehyde oxidase activity of the AA5 subfamily 1 (AA5_1) homolog. Transcriptomics and reverse genetics experiments on both CROs and three putative peroxidases/catalases (known activators of CROs) in JR2 failed to indicate direct roles in phytopathogenesis. Taken together, the data indicate that the biological roles of CROs and AA5_2 members, in particular, are not broadly conserved between foliar and vascular wilt phytopathogens. However, the biochemical characterization of an AA5_1 aldehyde oxidase and an AA5_2 aryl-alcohol oxidase from , as well as an AA5_2 ortholog from VL43, provides a foundation for further functional elucidation, as well as new biocatalysts for biotechnological applications.IMPORTANCEPlant pathogens constitute a considerable burden to human society by attacking crops and reducing agricultural yields. Oxidative enzymes are often key weapons in the arsenal deployed by phytopathogens in the effort to breach cell walls and extract nutrients. Here, the characterization of the biochemical specificities of copper radical oxidases (CROs) from Verticillium wilt/stripe fungi defines a range of possible alcohol and aldehyde substrates and outlines the potential of these enzymes for their biotechnological application for chemical valorization. Although specific gene knockouts did not reveal a biological function for these CROs, we now know that the molecular mechanism of CRO-mediated pathogenesis previously observed in foliar phytopathogens from the genera and is not conserved in the vascular wilt pathogen . - Source: PubMed
Publication date: 2026/06/03
Fong Jessica KChen Ying-YuHarting RebekkaKlein MoritzLewandowski SimoneMathieu YannHaon MireilleBissaro BastienBerrin Jean-GuyFeussner IvoBraus Gerhard HBrumer Harry - Adoptive cellular immunotherapy (ACT) such as CAR‑T therapy holds promise for cancer treatment. However, genetically engineered T cells often undergo terminal differentiation during ex vivo expansion, which limits their persistence and antitumor efficacy . Early‑differentiated T‑cell subsets exhibit better survival and proliferative capacity after infusion. In our previous work, we isolated four T‑cell subsets at different differentiation stages: naïve T cells (T), stem cell‑like memory T cells (TSCM), central memory T cells (T), and effector memory T cells (T), and obtained their miRNA expression profiles via high‑throughput sequencing. In the present study, we found that hsa‑miR‑142‑5p is highly expressed in TSCM cells and gradually decreases during T‑cell differentiation. - Source: PubMed
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