SerpinE1 _ PLANH1 _ PAI1 Antibody
- Known as:
- SerpinE1 _ PLANH1 _ PAI1 Antibody
- Catalog number:
- 10296-RP01
- Product Quantity:
- 200
- Category:
- -
- Supplier:
- Smart Serology
- Gene target:
- SerpinE1 _ PLANH1 PAI1 Antibody
Related genes to: SerpinE1 _ PLANH1 _ PAI1 Antibody
- Gene:
- SERPINE1 NIH gene
- Name:
- serpin family E member 1
- Previous symbol:
- PLANH1, PAI1
- Synonyms:
- PAI
- Chromosome:
- 7q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
Related products to: SerpinE1 _ PLANH1 _ PAI1 Antibody
Related articles to: SerpinE1 _ PLANH1 _ PAI1 Antibody
- Recurrent respiratory papillomatosis (RRP) is an HPV-associated airway disease with incompletely defined inflammatory and tissue-remodeling programs. - Source: PubMed
Publication date: 2026/08/11
Ma YunWang XiaojieZhang YongjuLi QingliangDou Fenfen - This study aimed to identify steroid metabolism-related molecular subtypes, investigate the gene expression patterns of these subtypes, and construct a prognostic risk model as well as predict therapeutic response in gastric cancer. - Source: PubMed
Publication date: 2026/08/07
Li LinenZhu HuilingGao GuangChen Hao - Pseudomyogenic hemangioendothelioma is rare, usually indolent vascular tumor characterized immunohistochemically by SERPINE1-FOSB fusion, presenting as multiple bone and soft tissue lesions, affecting males in their 3rd-4th decades. - Source: PubMed
Publication date: 2026/08/08
Moghaddam Amin MaysamSükösd ÁkosAntal ImreSápi ZoltánPápai ZsuzsannaSzendrői Miklós - Esophageal squamous cell carcinoma (ESCC) exhibits heterogeneous responses to immune checkpoint blockade, highlighting the need to define tumor-intrinsic mechanisms driving resistance to PD-L1 inhibition. Here, we identified GTP-binding protein overexpressed in skeletal muscle (GEM) as a tumor cell-intrinsic regulator associated with poor response to anti-PD-L1 therapy in ESCC. GEM expression in tumor cells drove tumor-associated macrophage (TAM)-mediated immunosuppression, leading to reduced CD8⁺ T cell infiltration and impaired cytotoxic function. Mechanistically, GEM induced SERPINE1 expression that was secreted and acted on macrophage LRP1 to drive alternative activation and suppress antitumor immunity. GEM enhanced SERPINE1 expression through a MKK3-RACK1-p38-MEF2A cascade. GEM signaling was reinforced by a metabolically coupled feedback mechanism. Macrophages exposed to GEM-high tumor cells promoted tumor cell glycolysis and lactate production, which drove AARS1-dependent lactylation of GEM and strengthened its interaction with RACK1 to amplify downstream signaling. Disruption of the SERPINE1-LRP1 axis restored CD8⁺ T cell activity and enhanced response to PD-L1 blockade in vivo. Pharmacological perturbation of GEM-dependent signaling remodeled the tumor immune microenvironment and improved responses to PD-L1 blockade. Together, these findings define a GEM-SERPINE1-LRP1 signaling axis that drives macrophage-mediated immune suppression and suggest that targeting this pathway may enhance the efficacy of PD-L1 blockade in ESCC. - Source: PubMed
Publication date: 2026/08/06
Wu LinfengRen ChanghaoZhang YifeiWang GaojiaZhou Kai-QianGuo KechenZhao ZhiwangJiang DongxianLiu YanboZhou YuningZhou YanjunWang MengtingDing HanRuan YuanyuanZhou PinghongZhang Yiqun - Coagulation and inflammation play crucial roles in the initiation and progression of cancer, and they exhibit a synergistic effect. However, a hematological biomarker and risk model based on coagulation and inflammatory have not yet been established in breast cancer. - Source: PubMed
Publication date: 2026/07/22
Li FuchengGao TianXia JingqiWang JiananSu QiuyueChen YurongBa YulingJia SiyuanLi ZhaotingWang YilinXiao Min