PRLR _ Prolactin receptor Antibody
- Known as:
- PRLR _ Prolactin receptor Antibody
- Catalog number:
- 10278-R101
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Smart Serology
- Gene target:
- PRLR _ Prolactin receptor Antibody
Related genes to: PRLR _ Prolactin receptor Antibody
- Gene:
- PRLR NIH gene
- Name:
- prolactin receptor
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 5p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1989-12-01
- Date modifiied:
- 2016-10-05
Related products to: PRLR _ Prolactin receptor Antibody
Related articles to: PRLR _ Prolactin receptor Antibody
- Cushing syndrome (CS) during pregnancy is rare but is associated with substantial maternal and fetal risks. Although aberrant activation of G protein-coupled receptors (GPCRs), particularly the luteinizing hormone/human chorionic gonadotropin receptor, has been implicated in pregnancy-related hypercortisolism, non-GPCR mechanisms remain incompletely defined. We report a case of adrenocorticotropic hormone-independent CS during pregnancy caused by a cortisol-producing adrenocortical adenoma. Integrative molecular analyses of the resected tumor, including ribonucleic acid sequencing and immunohistochemistry, demonstrated increased expression of the prolactin receptor (PRLR) compared with adjacent normal adrenal tissue. PRLR is a member of the type I cytokine receptor family and is expressed in normal adrenal glands; however, its potential role in adrenal tumors has not been well characterized. To examine its functional relevance, primary cell cultures derived from independent cortisol-producing adenomas from nonpregnant women were treated with recombinant prolactin (PRL). PRL induced a dose-dependent increase in both cortisol secretion into the culture medium and intracellular cortisol levels. Following unilateral adrenalectomy, hypercortisolism resolved, and maternal and neonatal outcomes were favorable. These data provide molecular and functional evidence supporting a contributory role of PRLR in pregnancy-associated hypercortisolism, potentially triggered by physiological PRL elevations during gestation. - Source: PubMed
Publication date: 2026/07/02
Naka MasamitsuIshiwata KazukiSuzuki SawakoKouchi YusukeKishimoto TakashiYokote Koutaro - Non-functioning pituitary adenoma (NFPA) is the most common pituitary tumor. Due to the lack of hormone hypersecretion, it is often diagnosed when the tumor enlarges and gives compression symptoms. Surgical resection is the primary treatment modality; however, complete remission rates remain suboptimal. In this study, we aimed to investigate differentially expressed genes (DEGs) that may be involved in NFPA pathogenesis. - Source: PubMed
Uzkul Nisa DevrimAkkoyunlu Deniz SunnetciCabuk BurakIsik Elif BusraIskenderoglu Elmas TunaKeskin Seda ErenCine NaciSavli Hakan - To elucidate the central mechanism of pituitary-derived prolactin (PRL) in hepatic lipid homeostasis and identify therapeutic targets for metabolic dysfunction-associated fatty liver disease (MASLD). - Source: PubMed
Publication date: 2026/06/03
Zhu YeWu KexinWu TianyuFang DaZhang PengziWang JinBi Yan - Hyperprolactinemia is commonly caused by pituitary prolactinomas or medications and is typically managed with dopamine agonists (DAs). However, ectopic prolactin secretion from non-pituitary sources is rare and often unresponsive to medical therapy. Disseminated peritoneal leiomyomatosis (DPL), a benign condition characterized by diffuse intra-abdominal smooth muscle nodules, has not been previously reported as a source of ectopic prolactin production. The pathogenesis of DPL remains unclear, and no standardized treatment exists. Here we report a rare case of hyperprolactinemia in a female patient caused by DPL, who was successfully managed by surgical resection and postoperative leuprorelin therapy. - Source: PubMed
Publication date: 2025/12/19
Liu ZilingShen YangmeiHe Xiang - Heat stress (HS) is among the most economically consequential environmental challenges to global dairy production, causing progressive declines in milk yield, compositional quality, and mammary cellular integrity. The temperature-humidity index (THI) is the primary thermal load metric, with performance-impairment thresholds typically beginning at THI 68 in Holstein cattle, with severe impacts manifesting beyond THI 72; breed-specific thresholds for Jersey, Brown Swiss, and Simmental cows differ owing to their lower metabolic heat load and greater inherent thermotolerance. At the molecular level, HS activates heat shock protein networks-notably , , and -through / transcriptional activation, while simultaneously suppressing casein genes (, , ), lipogenic genes (, , ), amino acid transporters (, ), and mTOR-AKT-STAT5 translational machinery, collectively impairing milk biosynthetic capacity. Pro-apoptotic signaling (, upregulation; downregulation) and mitochondrial dysfunction further compromise mammary epithelial viability. Post-transcriptional regulation through miRNA, circRNA, and lncRNA competing endogenous RNA networks, alongside epitranscriptomic m6A modifications, adds further regulatory complexity. Genome-wide association studies have identified SNPs in , , , and as thermotolerance candidates compatible with sustained milk production. Nutritional supplementation with methionine, arginine, and taurine partially restores cellular synthetic capacity. Integrating multi-trait genomic selection with introgression, precision cooling, and targeted nutrition offers the most viable path toward climate-resilient, high-producing dairy cattle. - Source: PubMed
Publication date: 2026/05/21
Ma QingshanTharwat MohamedAlshanbari Fahad AKhan Muhammad Zahoor