CD32b _ FCGR2B Antibody
- Known as:
- CD32b _ FCGR2B Antibody
- Catalog number:
- 10259-RP01
- Product Quantity:
- 200
- Category:
- -
- Supplier:
- Smart Serology
- Gene target:
- CD32b _ FCGR2B Antibody
Related genes to: CD32b _ FCGR2B Antibody
- Gene:
- FCGR2B NIH gene
- Name:
- Fc fragment of IgG receptor IIb
- Previous symbol:
- FCG2, FCGR2
- Synonyms:
- CD32, CD32B
- Chromosome:
- 1q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-21
- Date modifiied:
- 2016-10-05
Related products to: CD32b _ FCGR2B Antibody
Related articles to: CD32b _ FCGR2B Antibody
- N-glycans are essential components of glycoproteins, influencing their properties and functions. While biochemical pathways of glycosylation are well-characterized, their genetic regulation remains poorly understood. This study utilizes matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS) and ultra-high performance liquid chromatography-fluorescence detection (UHPLC-FD) to strengthen replication and further characterize previously identified genome-wide association signals for the total human plasma N-glycome (TPNG). Univariate and multivariate genetic association meta-analyses involved 3385 samples across 143 N-glycome traits from the Hoorn Diabetes Care System and DiaGene cohorts as well as 3224 samples across 117 N-glycome traits from TwinsUK, CEDAR, QMDiab and SABRE cohorts. We successfully replicated ten previously identified but not replicated glycosylation quantitative trait loci (glyQTLs) and prioritized five high-confidence putative causal genes, including the glycosyltransferase MGAT4B and inflammation-related genes - C3 and FCGR2B. The linkage-specific sialic acid derivatization in MALDI-MS enabled delineation of genetic effects on α2,3- and α2,6-sialylation. Mass spectrometry analysis, triggered and guided by association to a locus containing B3GAT1 glucuronosyltransferase, provided evidence for hexuronic acid-containing glycans in human blood plasma. These findings advance our understanding of the genetic regulation of protein N-glycosylation and highlight the complementarity of different analytical approaches in glycomics research. - Source: PubMed
Publication date: 2026/04/20
Timoshchuk AnnaNaber AnnemiekeSlieker RoderickSoplenkova AnnaMaslov DenisPotapova Nadezhda ANicolardi SimoneElders P J MSijbrands Eric J GSharapov SodboHart Leen M 'tHoek MandyWuhrer ManfredAulchenko Yurii S - High-grade serous ovarian cancer (HGSOC) is characterized by a complex tumor microenvironment and poor prognosis, yet the roles of specific tumor-associated macrophages (TAMs) subpopulations in driving disease progression remain elusive. - Source: PubMed
Publication date: 2026/04/06
Zhou JialuZeng TaoLiu YiYe MingxiaLi MingxiaZhang ZheMeng Yuanguang - Epithelial ovarian cancer (EOC) encompasses five major histological subtypes with marked genetic, immunological, and clinical heterogeneity. While genome-wide association studies (GWAS) have identified subtype-specific risk loci, a critical gap remains in understanding how plasma proteins influence immune-cell traits and contribute to EOC pathogenesis. - Source: PubMed
Publication date: 2026/04/03
Zhou JialuZeng TaoYe MingxiaLi MingxiaWen LiangLiu XinyiZhang ZheMeng Yuanguang - Ankylosing spondylitis (AS) is a chronic immune-mediated arthritis marked by persistent inflammation and progressive structural damage. Although dysregulation of programmed cell death (PCD) is increasingly recognized in AS pathogenesis, the full spectrum of transcript-level regulation remains unclear. Here, we employed Oxford Nanopore Technologies (ONT) long-read RNA sequencing to comprehensively profile peripheral blood transcriptomes from six AS patients and six matched healthy controls. Our analysis identified 1,088 differentially expressed genes (DEGs) and 1,812 differentially expressed transcripts (DETs), with upregulated transcripts enriched in apoptosis, autophagy, and transcriptional regulation. We further detected 50 transcripts with significant differential usage and 304 alternative splicing events affecting immune- and PCD-related genes, including , , and . Integrative multilayered analysis revealed 26 core genes, such as , , and , showing consistent dysregulation at gene, isoform, and splicing levels, highlighting convergent regulatory networks underlying immune imbalance and cell death in AS. These findings provide the first isoform-resolved transcriptomic landscape of PCD regulation in AS, which unveils extensive regulatory complexity and nominates a set of core genes for future mechanistic and therapeutic exploration. - Source: PubMed
Publication date: 2026/03/06
Cao XueLi PanlongPeng HaoranChen QiaoShi LipuChen DongChu TianshuCheng Yanwei - Nerve injury triggers complex molecular responses involving immune activation and neuronal damage, yet the key regulatory genes and their mechanisms remain poorly understood. Here, we integrated multi-transcriptomic datasets and machine learning to identify and validate novel biomarkers of nerve injury and elucidate their functional roles. - Source: PubMed
Cao ShumingYu ChengyueWang NanaXu JianhuaXu Weiguo