CD146 _ MCAM Antibody
- Known as:
- CD146 _ MCAM Antibody
- Catalog number:
- 10115-MM05
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Smart Serology
- Gene target:
- CD146 _ MCAM Antibody
Related genes to: CD146 _ MCAM Antibody
- Gene:
- MCAM NIH gene
- Name:
- melanoma cell adhesion molecule
- Previous symbol:
- -
- Synonyms:
- MUC18, CD146, MelCAM, METCAM, HEMCAM
- Chromosome:
- 11q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 1995-12-18
- Date modifiied:
- 2019-04-16
Related products to: CD146 _ MCAM Antibody
Related articles to: CD146 _ MCAM Antibody
- In recent years, some fibroblast growth factors (FGFs) have been reported to be promising therapeutic targets for neovascular age-related macular degeneration (nAMD). Interestingly, we found that the FGFR2b inhibitor bemarituzumab (FPA144) exerts a beneficial effect in a mouse choroidal neovascularization (CNV) model. Our current study aims to uncover the potential molecular mechanism by which FPA144 alleviates CNV. The effect of FPA144 was evaluated in a laser-induced CNV mouse model. Fundus fluorescein angiography (FFA), optical coherence tomography (OCT), and choroidal flat mounts were carried out for the quantitative assessment of CNV. Label-free quantitative proteomics analysis was performed to assess changes in molecular pathways. Primary cultured human umbilical vein endothelial cells (HUVECs) were used for further confirmation of the target pathway in vitro. FFA, OCT, and choroidal flat mounts demonstrate the protective effect of FPA144 in a mouse CNV model. Compared to the control group, the treated group has smaller vascular leakage areas or smaller CNV lesions. Proteomic analyses indicate that the melanoma cell adhesion molecule (MCAM, CD146)-Yes-associated protein 1 (Yap1) pathway may be involved in the effect of FPA144. Immunostaining of choroidal flat mounts and cryosections reveals decreased expression of CD146 and Yap1 in the vascular endothelial cells of the treated animals. Experiments on HUVECs further verify the inhibitory effect of FPA144 on vascular endothelial cells. Our findings demonstrate that FPA144 can efficiently inhibit the development of choroidal neovascularization in mice by downregulating CD146 and Yap1. - Source: PubMed
Publication date: 2026/04/27
Ding LiujunXie BintaoLv JinengZhou ZhonglouZhou XinWu KunchaoZhang QinLu FanWang CongQu JiaXiang LueChen Qi - French Guiana is home to one of the highest mosquito diversities in the world, with currently 242 species recorded, nearly half of them belonging to the genus Culex. These mosquitoes include vectors of human parasites and viruses, some of which are of significant public health concern. Understanding the host preferences of female Culex mosquitoes is essential but knowledge is still limited. The Zoo of French Guiana was chosen as an experimental site for its constant availability of diverse captive animals and a potential sentinel role for monitoring infectious diseases. - Source: PubMed
Publication date: 2026/05/13
Guidez AmandineLacour GuillaumeTalaga StanislasCarinci RomualdGaborit PascalRousset DominiqueBremand LaetitiaTirera SourakhataRouges CeliaDuval LindaAriey FrédericLavergne AnneDusfour IsabelleDuchemin Jean-Bernard - A growing body of evidence suggests that male infertility is a precursor to future health problems. This study aimed to develop a unique circulating biomarker that could contribute to the diagnosis of male infertility. - Source: PubMed
Publication date: 2026/05/12
Kikuchi RyosukeShibata TakahiroNakatochi MasahiroSei HarukaKobayashi YumikoKidoya HiroyasuMuramatsu FumitakaFurusawa NaomiKano KeikoMishiro-Sato EmiIshida HidekazuKatagiri YasuoSuzuki AtsuoMatsubara HirokazuTakano KyoheiFurui TatsuroKajiyama HiroakiOkura Hiroyuki - Microneedle (MN) technology is an appealing route for treating skin cancers, but remains many challenges, such as accommodating multiple theranostic functionalities and configuring personalized sensing, particularly given that MNs typically collect sample volumes from microliters to milliliters, necessitating suitable trace analysis techniques. In this study, we developed a versatile, multilayer, detachable MN administration system capable of simultaneous photocontrolled drug delivery therapy that operated based on real-time in situ conditions monitored by droplet-based PCR (dPCR). The detachable MN consisted of an innermost poly (ethylene glycol) diacrylate extraction layer, an outer gelatin methacryloyl drug-loaded layer containing Vemurafenib and black phosphorus (BP), and a polyvinyl alcohol connection layer designed for thermal detachment. The outer layer enabled light-responsive drug release through BP's photothermal properties, achieving 78% release within 24 h. Subsequently, the significant mechanical strength and swelling characteristics facilitated the effective extraction of approximately 26 µL of interstitial fluid within 10 min. Both in vitro and in vivo studies on melanoma demonstrated the platform's capability to enhance therapeutic efficacy while minimizing systemic toxicity. It enabled dPCR-based monitoring of MCAM and BRAF genes, including the drug-resistant V600E polymorphism, with detection limits of 223 copies/µL, along with digital proximity ligation assay detection of the protein markers IL-6, VEGF, and Ki-67 at 0.64 pg/mL. This well-designed biosystem highlighted its capability to interact with the pathophysiological environment, providing a preclinical proof-of-concept for minimally invasive theranostics in superficial tumors. - Source: PubMed
Publication date: 2026/05/11
Cheng YunLuan XiParvin RokshanaHu DingmengWu NanLin KeWang GanglingLi HuaqiongZhang LexiangYe Fangfu - Dental-derived mesenchymal stem cells show considerable variability in their differentiation potential due to the use of nonspecific surface markers and technical limitations in isolation protocols. This study aimed to employ single-cell RNA sequencing to compare the cellular composition of cultured stem cells from apical papilla (SCAPs) and dental pulp (DPSCs), with the goal of detecting subpopulations underlying their divergent regenerative behaviour and identifying markers that can facilitate future isolation and functional targeting. - Source: PubMed
Publication date: 2026/05/05
Shah Maanas SSayegh Mohamed AlKhalil Mennatullah MSundarabupathi ManoAlKhnbashi OmerSamaranayake LakshmanKhyriem CosterwellSultana MeharEgusa HiroshiJamal Mohamed