IL1R2 _ IL1RB _ CD121b Antibody
- Known as:
- IL1R2 _ IL1RB _ CD121b Antibody
- Catalog number:
- 10111-R020
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Smart Serology
- Gene target:
- IL1R2 _ IL1RB CD121b Antibody
Related genes to: IL1R2 _ IL1RB _ CD121b Antibody
- Gene:
- IL1R2 NIH gene
- Name:
- interleukin 1 receptor type 2
- Previous symbol:
- IL1RB
- Synonyms:
- CD121b
- Chromosome:
- 2q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1992-11-30
- Date modifiied:
- 2016-10-05
Related products to: IL1R2 _ IL1RB _ CD121b Antibody
Related articles to: IL1R2 _ IL1RB _ CD121b Antibody
- Piroplasmosis, including Theileriosis and Babesiosis, poses a threat to livestock health and productivity worldwide. However, the molecular mechanisms underlying breed-specific differences in resistance to piroplasmosis remain poorly understood. Compared to Bos taurus, Bos indicus generally exhibits greater resistance to diseases such as piroplasmosis and trypanosomiasis, as well as enhanced adaptability to hot and humid environments. Yunnan humped cattle, an indigenous B. indicus breed, are well adapted to coarse feed and harsh environments, yet the molecular basis of their disease resistance has not been systematically investigated. - Source: PubMed
Publication date: 2026/04/30
Chen YumingChen XiaonaLiu RongLi ChunqingXiao HengChen Shanyuan - Tertiary lymphoid structures (TLSs) are increasingly recognized as important components of the tumor immune microenvironment, yet their prognostic and immunological implications in clear cell renal cell carcinoma (ccRCC) remain incompletely characterized. In this study, we performed an integrated bioinformatic and translational analysis to investigate TLS-associated molecular features in ccRCC. Using TCGA-KIRC transcriptomic data, we identified three TLS-related molecular subtypes with distinct survival outcomes and immune microenvironment characteristics. Based on prognostic TLS-associated genes, we developed a four-gene TLS-derived score (CSF2, CXCL13, IL1R2, and SGPP2) that stratified patients into groups with significantly different overall survival. The TLS score remained an independent prognostic factor after adjustment for clinical variables. Interestingly, higher TLS scores were associated with increased immune infiltration but poorer survival outcomes, suggesting that TLS-associated transcriptional patterns may reflect heterogeneous immune functional states rather than uniformly effective antitumor immunity. Computational analyses indicated potential differences in predicted immunotherapy response and mutation landscapes between TLS score groups. Limited experimental validation using fresh ccRCC specimens supported the feasibility of TLS score assessment and provided preliminary histopathological context for TLS-associated immune features. Overall, this study proposes a TLS-derived transcriptional signature that may help capture immune heterogeneity in ccRCC and may provide a complementary framework for prognostic assessment. Further studies are required to validate its biological and clinical relevance. - Source: PubMed
Publication date: 2026/04/28
Zhou XuanyuZhao ZhongweiHuang KaiMa Guangxin - This study utilized a multi-omics and computational biology framework to investigate the therapeutic potential of the Traditional Chinese Medicine (TCM) formula Buti Huatan Tang (BTHTT) against chronic obstructive pulmonary disease (COPD). Significant physiological improvements were observed in a rat model following BTHTT intervention. Histological analysis showed a reversal of lung pathological damage, while biochemical assays, and transcriptomics confirmed the normalization of IL-1β and IL-1R2 levels. Additionally, metabolic profiling revealed that BTHTT corrected disruptions in T3 and T4 thyroid hormone levels. A negative correlation was observed between the IL-1β/IL-1R2 axis and these thyroid hormones, indicating that their regulation is associated with the formula's therapeutic effect. Beyond direct measurements, machine learning algorithms identified ten COPD signature genes from clinical databases. Pathway enrichment analysis suggests that BTHTT may act through cytokine-cytokine-receptor interactions and thyroid hormone synthesis pathways. Furthermore, while 283 components were identified in vivo, compounds such as tanshinone IIA and cryptotanshinone are currently considered candidate active substances. Their role as primary drivers is supported by a model in which they stably bind to IL-1R2; this inference is based on molecular docking and molecular dynamics (MD) simulations rather than direct experimental isolation. Overall, the data support a model in which BTHTT exerts a multi-target effect on COPD by modulating inflammation and metabolic homeostasis. This integrated approach provides a refined scientific basis for the clinical application of BTHTT and highlights specific pathways for future experimental validation. - Source: PubMed
Publication date: 2026/03/13
Zha XinGong Wen-WeiLi Xue-YingXia QingRuan Jing-HuaTan RongZhu Zhu-ShengLiu Shao-Bo - The lack of reliable diagnostic tools and relapse monitoring for latent tuberculosis infection (LTBI) constitutes a major obstacle to global tuberculosis (TB) control. This highlights an urgent need for robust animal models and predictive biomarkers. To address this, we report the successful establishment of a rapid murine model of recapitulating the active, latent, and relapse phases of TB within a compressed ten-week timeframe-hence termed the rapid multi-stage TB murine model. In this model, mice were first intravenously infected with , followed by a four-week isoniazid (INH) regimen starting at two weeks post-infection. By week six, pulmonary bacterial loads in most mice dropped below the detection limit, signifying the establishment of latency. Reactivation was subsequently triggered by a four-week administration of anti-TNF-α (Tumor Necrosis Factor-α) monoclonal antibody. Leveraging this reproducible and time-efficient model, we performed transcriptomic profiling of peripheral blood and identified a distinct sixteen-gene signature (including , , , , , , , , , , , , , , , ) that dynamically tracks disease progression. Collectively, these findings not only provide a valuable and efficient preclinical tool but also deliver transformable candidate biomarkers with immediate potential to guide the development of novel diagnostic strategies for LTBI surveillance and management. - Source: PubMed
Publication date: 2026/03/11
Li HaifengWang JunfeiWang YuLiu FanTang JunSun MengmengZhan Lingjun - Asthma is a chronic inflammatory respiratory disease characterized by significant heterogeneity, which complicates accurate patient classification and management. With the aim of defining new, reliable biomarkers, we previously evaluated the potential of 94 genes to differentiate allergic asthma (AA) from nonallergic asthma (NA) based on their expression in peripheral blood mononuclear cells (PBMCs). Here, the most promising biomarkers were further analyzed in a 2-year longitudinal cohort of 24 healthy controls (HCs), 18 NA patients, and 51 AA patients. - Source: PubMed
Publication date: 2026/03/26
Cremades-Jimeno LucíaLópez-Ramos MaríaBaos SelenFernández-Santamaría Rubénde Pedro María AMahíllo-Fernández IgnacioRosales-Ariza CristinaOlaguibel José MDel Pozo VictoriaCaballero María LLuna-Porta Juan AQuirce SantiagoBarroso BlancaBetancor DianaValverde-Monge MarcelaSastre JoaquínCárdaba Blanca