CD84 _ SLAMF5 Antibody
- Known as:
- CD84 _ SLAMF5 Antibody
- Catalog number:
- 10100-RP01
- Product Quantity:
- 200
- Category:
- -
- Supplier:
- Smart Serology
- Gene target:
- CD84 _ SLAMF5 Antibody
Related genes to: CD84 _ SLAMF5 Antibody
- Gene:
- CD84 NIH gene
- Name:
- CD84 molecule
- Previous symbol:
- -
- Synonyms:
- SLAMF5, hCD84, mCD84
- Chromosome:
- 1q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-01-18
- Date modifiied:
- 2018-03-26
- Gene:
- SLAMF9 NIH gene
- Name:
- SLAM family member 9
- Previous symbol:
- -
- Synonyms:
- CD2F-10, CD84-H1, SF2001
- Chromosome:
- 1q23.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-10-29
- Date modifiied:
- 2016-10-05
Related products to: CD84 _ SLAMF5 Antibody
Related articles to: CD84 _ SLAMF5 Antibody
- The SLAM family of human genes currently consists of seven related members of the immunoglobulin superfamily, membrane-associated proteins, including CD150 (SLAM), CD244 (2B4), CD84, CD229 ( Ly-9), BLAME, CD48, and 19A. These genes are expressed to varying degrees in subsets of immune cells (T, B, natural killer, and myeloid cells) and may function as ligands or receptors. This set of genes, related to CD2 and CD58 on Chromosome (Chr) 1p98, are found clustered close together in the human genome on Chr 1q22. Four of these family members (CD150, CD244, CD84, CD229) contain conserved tyrosine motifs in their cytoplasmic tails that enable them to bind intracellular signaling molecules SAP and EAT-2. SAP is mutated in human X-linked lymphoproliferative disease (XLP), and studies in XLP patients have shown that improper signaling via molecules that bind SAP contributes to the disease. We have identified two new members of the SLAM family (SF), which we term SF2000 and SF2001, which are expressed in immune cells and map in the SLAM gene cluster. SF2001 does not contain SAP-binding motifs in its short cytoplasmic tail. SF2000, which is co-expressed with SAP in T cells, binds both SAP and EAT-2. The data suggest that signaling through SF2000, together with CD150, CD244, CD84, and CD229, is controlled by SAP and therefore contributes to the pathogenesis of XLP. - Source: PubMed
Publication date: 2002/01/23
Fraser Christopher CHowie DuncanMorra MassimoQiu YubinMurphy CurranShen QiongGutierrez-Ramos Jose-CarlosCoyle AnthonyKingsbury Gillian ATerhorst Cox