CNDP1 _ CN1 Antibody (Antigen Affinity Purified)
- Known as:
- CNDP1 _ CN1 Antibody (Antigen Affinity Purified)
- Catalog number:
- 10077-RP04
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Smart Serology
- Gene target:
- CNDP1 _ CN1 Antibody (Antigen Affinity Purified)
Related genes to: CNDP1 _ CN1 Antibody (Antigen Affinity Purified)
- Gene:
- CNDP1 NIH gene
- Name:
- carnosine dipeptidase 1
- Previous symbol:
- -
- Synonyms:
- MGC10825, CN1, CPGL2, HsT2308
- Chromosome:
- 18q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-04-14
- Date modifiied:
- 2016-05-20
Related products to: CNDP1 _ CN1 Antibody (Antigen Affinity Purified)
Related articles to: CNDP1 _ CN1 Antibody (Antigen Affinity Purified)
- - Source: PubMed
Publication date: 2026/04/21
Hettler Steffen AMoissl AngelaDelgado Graciela ESkladny HeykoMärz WinfriedKrämer Bernhard KYard Benito AKleber Marcus E - Duck meat is highly appreciated for its unique flavor and rich nutritional value, and metabolites have become important phenotypic indicators of meat quality. The Sansui duck, a celebrated local breed from Guizhou, is known for its tender, savory meat, yet its metabolomic composition and underlying genetic basis remain unexplored. In our study, non-targeted LC-MS/MS metabolomics of 305 Sansui duck breast muscles detected 4,729 metabolic features (459 annotated) and identified 136 sex-differential metabolites enriched in fatty acid and amino acid metabolism pathways. Metabolite-based genome-wide association studies (mGWAS) further identified 355 significant LD-independent SNPs and 267 potential candidate genes associated with 103 metabolites. The signal peaks for amino acid metabolites were mainly concentrated on chromosomes 1, 5, and 20. A QTL on chromosome 2 (63.90-64.10 Mb), containing candidate genes ZNF407, CNDP1, and CNDP2, was identified for three methylglyoxal derivatives, with the lead SNP (chr2: 63928783) accounting for about 18.3 % of their variance. Additional QTLs on chromosomes 5, 20, 1, and 24 were associated with Carnosine, N-Acetylhistidine, Acetylcholine, N-Acetyl-L-aspartic acid, 11b-PGF2a, and 12(S)-HpETE. These intervals harbor BBOX1 and ACACA, two key rate-limiting enzymes in fatty acid metabolism. Our results revealed the genetic basis of breast muscle metabolites in Sansui ducks and identified associated genetic loci and candidate genes. These findings deepen our understanding of muscle metabolism and provide valuable insights for improving meat quality and nutritional breeding. - Source: PubMed
Publication date: 2026/03/18
Feng YulongXu MengruYu XintongYang ZhaoQi JingjingXi YangGuo ShihaoHan XuLi MeijuanLu YuxiDai GuotaoTian ChengchengZhao YuHuang AnqiLi LiangLiu Hehe - Berberine lowers both lipids and glucose, yet its role on cardiometabolic disease risk remain unclear. Based on a randomized controlled trial of berberine (registered in ClinicalTrials.gov on Dec 2018, NCT03770325), leveraging proteomics and sex hormones data, we built a signature reflecting response to berberine using elastic net regression. We then assessed its associations with ischemic heart disease (IHD) and diabetes in UK Biobank using logistic regression and for causal relationship, using bi-directional Mendelian randomization (MR), and estimates of each protein/hormone. The signature was related to lower IHD and diabetes risks (OR for IHD 0.85, 95% CI 0.79-0.91; diabetes 0.88, 0.80-0.96 using MR). SHBG and PRSS2 might explain the beneficial association with IHD; testosterone, SHBG, CCL5, CNDP1, F11, LCN2, and THBS4 might explain the association with diabetes, which provides insights for drug development. Our study suggests beneficial associations of berberine with IHD and diabetes, which requires confirmation in large clinical trials. - Source: PubMed
Publication date: 2026/03/25
Zhao Jie VSarsani VishalChen BingYun HuanHu JieLiang Liming - The acute gouty arthritis (AGA) to chronic gouty arthritis (CGA) transition is a critical phase leading to irreversible joint damage and systemic complications. However, current molecular mechanism investigations have remained limited to single-omics approaches that lack comprehensive multi-omics explorations. We integrate high-depth data-independent acquisition (DIA) proteomics and untargeted metabolomics to analyze serum samples from healthy controls ( =28), AGA ( = 31), and CGA ( = 14) patients to address this gap. Through differential expression analysis, we identified nine persistently dysregulated pivotal proteins with robust discriminative capacity, including the urate excretion regulator ZBTB20 and inflammation/immune-related proteins (GUCY1A2, CNDP1, LYZ, SERPINA5, GSN). Additionally, 11 consistently altered core metabolites with diagnostic potential were detected, indicating perturbations in sex hormones, thyroid hormones, gut microbiota-derived metabolites, environmental exposures, and nutritional factors. Multi-omics KEGG enrichment analysis highlighted thyroid hormone synthesis, AMPK signaling pathway, and taurine and hypotaurine metabolism as central pathways. Correlation network analysis further revealed significant immune dysregulation, illustrating an evolution from acute immune activation to chronic inflammation during AGA-to-CGA progression. Our study establishes that a coordinated disruption of the thyroid hormone-AMPK-taurine metabolic axis and concomitant immune microenvironment remodeling is associated with chronic gout development. These findings provide critical targets for developing early diagnostic indicators and targeted interventions for CGA. - Source: PubMed
Publication date: 2025/12/25
Zhu GuizhenLuo YuanZheng XiangyiMei ZhusongYe QiaoPeng JieDuan FengsenCui YueyingAn PeiyuSong YangqianLi HongxiaZhang HaitaoWang Guangyun - Metabolic diseases, associated with high morbidity and mortality rates, pose a challenge to global public health and a significant burden on society. Since the discovery of carnosinase-2(CNDP2)-mediated synthesis of lactate and phenylalanine, which subsequently forms N-Lactoyl-Phenylalanine (Lac-Phe) to inhibit food intake and obesity, the carnosine dipeptidases (CNDPs)have attracted increasing scientific interest. Although the role of CNDP in diabetic nephropathy has been extensively studied, its role in other metabolic diseases remains unclear. In this study, we have overviewed the enzymatic and other roles of CNDP proteins focusing on recent research demonstrating the regulatory roles of CNDP on various metabolic diseases. Increasing evidence indicates that carnosinase-1(CNDP1) and carnosinase-2 are crucial for the management of metabolic diseases under both physiological and pathological conditions. Moreover, interest in the pharmacological modulators of CNDP has been steadily increasing. Overall, we suggest that CNDP can be considered a promising therapeutic target for the effective treatment of metabolic diseases. - Source: PubMed
Publication date: 2025/08/13
Zhou LiangZhang ShuxiaZhang YunqiLuo YunSun Xiaobo