S100A9 _ CAGB _ P14 Protein (Native)
- Known as:
- S100A9 _ CAGB _ P14 Protein (Native)
- Catalog number:
- 11145-HNAE
- Product Quantity:
- 50
- Category:
- -
- Supplier:
- Smart Serology
- Gene target:
- S100A9 _ CAGB P14 Protein (Native)
Related genes to: S100A9 _ CAGB _ P14 Protein (Native)
- Gene:
- S100A9 NIH gene
- Name:
- S100 calcium binding protein A9
- Previous symbol:
- CAGB, CFAG
- Synonyms:
- P14, MIF, NIF, LIAG, MRP14, MAC387, 60B8AG, CGLB
- Chromosome:
- 1q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1989-05-19
- Date modifiied:
- 2018-05-02
Related products to: S100A9 _ CAGB _ P14 Protein (Native)
Related articles to: S100A9 _ CAGB _ P14 Protein (Native)
- Benzene is a well-established environmental leukemogen, but how benzene-induced myelosuppression evolves into rapid malignant transformation remains unclear. To deconstruct this progression, Mll-Af9 chimeric mice were subjected to chronic benzene inhalation. Following exposure, mice exhibited prolonged hematotoxicity, but the initially suppressed white blood cells and CD45.2⁺ pre-leukemic cells progressively rebounded, significantly exceeding control levels by week 10. Serial colony-forming assays revealed suppressed clonogenic capacity at week 8, followed by a robust enhancement at week 10 that was predominantly driven by sustained colony-forming unit-granulocyte-macrophage progenitor (CFU-GM) expansion. These phenotypic shifts pinpointed the 8-10-week interval as the critical tipping point for the suppression-to-proliferation switch. Single-cell RNA sequencing identified granulocyte-macrophage progenitors (GMPs) as the principal cellular drivers of this transformation. During the suppressive phase, a distinct GMP subset displayed cell cycle arrest yet aberrantly co-activated myeloid differentiation (CEBPA) and pro-leukemic self-renewal (HOXA9/MEIS1) programs, accompanied by marked S100a8/S100a9 upregulation. This stress-adapted phenotype transcriptional state was associated with subsequent transcriptional reversal and clonal outgrowth that ultimately shortened overall survival. Clinical relevance was further supported by The Cancer Genome Atlas cohort, where elevated S100A8/S100A9 expression correlated with poorer survival in acute myeloid leukemia patients. Collectively, these findings delineate a stress-driven evolutionary pathway linking benzene-induced marrow suppression to early pre-leukemic adaptation and highlight S100a8/S100a9-associated transcriptional programs as potential early molecular features of benzene-related leukemogenic progression. - Source: PubMed
Publication date: 2026/05/12
Zhou JinSui PinpinLi YingHe JinxuLu YedanZheng MinSong XiangrongYu TaoCheng XiurongXing Caihong - New biomarkers are needed to improve treatment selection in patients with metastatic clear cell renal cell carcinoma (CCRCC). This study aims to identify predictive biomarkers through the investigation of serum proteins related to angiogenesis and tumor immune escape, alongside metabolic patterns associated with clinical outcomes. - Source: PubMed
Publication date: 2026/04/29
Quintás GuillermoSanmartín ElenaGarcia-Gimenez AliciaMuñoz-Langa JoséCollado AidaSuárez CristinaGarcía Del Muro XavierMéndez-Vidal María JoséGarcía-Sánchez JoséSalvador-Coloma CarmenLaínez NuriaGallardo EnriqueMunárriz JavierVázquez SergioMolins CarmenFont de Mora JaimeReynés Gaspar - Relapsed/refractory (R/R) acute myeloid leukemia (AML) remains difficult to treat due to limited actionable targets and frequent drug resistance. Integrated analyses of multiple AML cohorts identified S100A9 as a candidate factor associated with disease aggressiveness and suboptimal therapeutic response in R/R AML. - Source: PubMed
Publication date: 2026/05/14
Hu ChujiaoWan JunzhaoMa DanZhu RenguangWang YijuanLi RuiyingWang PingZuo ShiTang LeiChen Tengxiang - Major depressive disorder (MDD) has been increasingly associated with low-grade inflammation, with neutrophils playing a central role. Calprotectin is a mainly neutrophil-derived inflammatory mediator. We investigated whether serum calprotectin levels are higher in patients with MDD than in healthy controls and whether the S100A9 rs3014866 polymorphism is associated with serum calprotectin levels and with MDD. - Source: PubMed
Publication date: 2026/05/13
Akbas FurkanBaykan OzgurAvcikurt Ayla SolmazBaykan Hayriye - Acute pancreatitis (AP) frequently progresses to systemic inflammation and acute lung injury, but the circulating mediators that couple pancreatic inflammation to remote organ damage remain poorly characterized. Following our finding that plasma exosomes induce AP-associated lung injury by triggering NOD-like receptor protein 3 (NLRP3)-dependent pyroptotic death in alveolar macrophages (AMs), this study aims to identify exosome-encapsulated S100A8/A9 derived from Kupffer cells (KCs) as a critical propagator of this inflammatory cascade. - Source: PubMed
Publication date: 2026/05/12
He Wen-QiLiu YiTang Ying-RuiWang RuiChen Chang-PingLv Xiao-QinSha Yuan-FeiRen Jian-Dong