Interferon omega_1 _ IFNω _ IFNW1 Protein
- Known as:
- Interferon omega_1 _ Interferonω _ IFNW1 Protein
- Catalog number:
- 10353-H01H
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Smart Serology
- Gene target:
- Interferon omega_1 _ IFNω IFNW1 Protein
Related genes to: Interferon omega_1 _ IFNω _ IFNW1 Protein
- Gene:
- IFI16 NIH gene
- Name:
- interferon gamma inducible protein 16
- Previous symbol:
- -
- Synonyms:
- IFNGIP1, PYHIN2
- Chromosome:
- 1q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 1993-09-29
- Date modifiied:
- 2016-10-05
- Gene:
- IFIT1 NIH gene
- Name:
- interferon induced protein with tetratricopeptide repeats 1
- Previous symbol:
- G10P1, IFI56, IFNAI1
- Synonyms:
- GARG-16
- Chromosome:
- 10q23.31
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2015-11-27
- Gene:
- IFNA1 NIH gene
- Name:
- interferon alpha 1
- Previous symbol:
- -
- Synonyms:
- IFNA@, IFL, IFN, IFN-ALPHA, IFNA13, IFN-alphaD
- Chromosome:
- 9p21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-01-14
- Date modifiied:
- 2016-10-05
- Gene:
- IFNA2 NIH gene
- Name:
- interferon alpha 2
- Previous symbol:
- -
- Synonyms:
- IFNA, IFN-alphaA
- Chromosome:
- 9p21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-01-14
- Date modifiied:
- 2016-10-05
- Gene:
- IFNA4 NIH gene
- Name:
- interferon alpha 4
- Previous symbol:
- -
- Synonyms:
- MGC142200, IFN-alpha4a
- Chromosome:
- 9p21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-01-14
- Date modifiied:
- 2016-10-05
Related products to: Interferon omega_1 _ IFNω _ IFNW1 Protein
Related articles to: Interferon omega_1 _ IFNω _ IFNW1 Protein
- Marek's disease (MD) is caused by the highly contagious Marek's disease virus (MDV), a tumorigenic alphaherpesvirus. The disease is presently managed through vaccination. Nevertheless, the dynamic nature of MDV presents challenges, as new virulent strains may arise that can potentially overcome existing vaccine-mediated immunity. To address this, new and more effective vaccines are crucial. The immune system's first line of defense against infections is the innate immune response, where type I interferons (IFN-I) play a key role. As with other alphaherpesviruses, MDV encodes numerous genes capable of modulating IFN-I production during infection. Ablation of these genes in MDV could result in attenuation, thereby facilitating the creation of novel vaccine strains with augmented IFN-I induction during infection. Hence, a system to identify immunomodulatory MDV gene products that impede IFN-I production in avian innate immune cells is required. Herein, we present an innovative screening method that quantifies the expression of Interferon Omega 1 (IFNω1) in an avian macrophage-like cell line expressing MDV genes via recombinant lentivirus (rLV) integration. Five MDV gene products hypothesized to inhibit IFN-I production (Meq, US3, R-LORF4, UL46, and UL48) were assayed in our screening system. Stable expression of all MDV genes was obtained when rLV was utilized to insert these genes into HD11 cells. Additionally, we established the optimal conditions for activation of the IFN-I response in HD11 cells using a 2 kb double-stranded DNA segment delivered by transfection as a stimulant. With this approach, we demonstrated that these MDV gene products significantly decreased the gene expression of IFN-I when activated by transfection with double-stranded DNA. - Source: PubMed
Publication date: 2026/03/27
Alvarez-Narvaez SonsirayConrad Steven JKim TaejoongSpatz StephenDunn John R - Feline chronic gingivostomatitis (FCGS) is a challenging disease with unclear causes and limited treatment options. The most effective treatment for FCGS is tooth extraction. However, most cats require additional drug treatment for refractory FCGS even after undergoing extractions. We hypothesized that the combination of interferon-ω (IFN) and cyclosporine (CsA) would improve clinical outcomes. This study aimed to evaluate the long-term efficacy of IFN and CsA in FCGS using Stomatitis Disease Activity Index (SDAI) scores. In this study, the treatment process was divided into two stages: in the surgical stage (Stage 1), all cats underwent tooth extraction combined with submucosal IFN injection; in the immunomodulatory stage (Stage 2), additional IFN/CsA treatment was administered to cats with refractory FCGS. - Source: PubMed
Publication date: 2025/12/16
Choe Kue HwanJang KwangsikKim Se EunJo Hyun Min - The type-I interferon family is well known for its critical role in innate immunity. It comprises several members, among which IFN-α and IFN-β are the most extensively studied, with important antiviral and immune-modulatory functions. Recent findings linking autoantibodies against type-I interferons to severe COVID-19 suggest a potential role for IFN-ω in combating SARS-CoV-2 infection. However, little is known about human IFN-ω, as most research on this interferon has been conducted in feline models. Here, we demonstrate that human IFN-ω is secreted at levels comparable to those of IFN-α or IFN-β upon stimulation with inflammatory agonists and triggers a robust antiviral response, inhibiting SARS-CoV-2 infection in vitro. Moreover, IFN-ω enhances the effector functions of antigen-specific CD8 T cells primed de novo from healthy donor cells, highlighting its capacity to promote strong cellular immunity. Our results position IFN-ω as a key member of the type-I interferon family, with promising potential for therapeutic and vaccine applications. - Source: PubMed
Nguyen Hoang OanhPinson Patricia RecordonAndreola Marie-LinePapagno LauraAppay Victor - The combination of transcriptional profiling and genotype data analyses enables the identification of genetic variants that may affect gene expression (eQTL - expression quantitative trait loci). This study aimed to identify cis-eQTL in Nellore cattle muscle tissue and determine their biological processes related to the immune system and involved eGenes. Genotypic data (SNP-Chip) and gene expression data (RNA-Seq) from a commercial population of 80 Nellore animals were evaluated. For the cis-eQTL identification, association tests were conducted for all variants near the gene (cis variants), followed by permutation tests to correct for multiple comparisons. Our analyses revealed 828 top cis-eQTL related to 1,062 genes of which most of these variants were in intronic and intergenic regions. The eQTLs rs109525554, rs109589165, rs110192253, rs133127698, rs137742430, rs41803313, rs43366333, and rs43711242 were associated with susceptibility and resistance to infections in cattle. Additionally, interferon family eGenes, such as IFNT3, IFN-TAU, IFNK, FYN, and IFNW1, and endothelial leukocyte migration, such as PRKCG and CXCL10 were found. These eGene families were linked to biological processes of innate and adaptive immune responses and associated with somatic cell scores in cattle, respectively. Our results may have implications for selecting desirable resistance traits in animals bred for production and highlight the importance of studying genetic variants involved in quantitative traits to improve our understanding of genetic mechanisms underlying gene expression regulation of adaptive traits in cattle. - Source: PubMed
Publication date: 2024/12/03
Ferreira Dos Santos Thaís CristinaSilva Evandro NevesFrezarim Gabriela BonfáSalatta Bruna MariaBaldi FernandoSimielli Fonseca Larissa FernandaDe Albuquerque Lucia GalvãoMagalhães Muniz Maria MalaneDos Santos Silva Danielly Beraldo - Glioma, a type of brain tumor, poses significant challenges due to its heterogeneous nature and limited treatment options. Interferon-related genes (IRGs) have emerged as potential players in glioma pathogenesis, yet their expression patterns and clinical implications remain to be fully elucidated. We conducted a comprehensive analysis to investigate the expression patterns and functional enrichment of IRGs in glioma. This involved constructing protein-protein interaction networks, heatmap analysis, survival curve plotting, diagnostic and prognostic assessments, differential expression analysis across glioma subgroups, GSVA, immune infiltration analysis, and drug sensitivity analysis. Our analysis revealed distinct expression patterns and functional enrichment of IRGs in glioma. Notably, IFNW1 and IFNA21 were markedly downregulated in glioma tissues compared to normal tissues, and higher expression levels were associated with improved overall survival and disease-specific survival. Furthermore, these genes showed diagnostic capabilities in distinguishing glioma tissues from normal tissues and were significantly downregulated in higher-grade and more aggressive gliomas. Differential expression analysis across glioma subgroups highlighted the association of IFNW1 and IFNA21 expression with key pathways and biological processes, including metabolic reprogramming and immune regulation. Immune infiltration analysis revealed their influence on immune cell composition in the tumor microenvironment. Additionally, elevated expression levels were associated with increased resistance to chemotherapeutic agents. Our findings underscore the potential of IFNW1 and IFNA21 as diagnostic biomarkers and prognostic indicators in glioma. Their roles in modulating glioma progression, immune response, and drug sensitivity highlight their significance as potential therapeutic targets. These results contribute to a deeper understanding of glioma biology and may inform the development of personalized treatment strategies for glioma patients. - Source: PubMed
Publication date: 2024/07/03
Cheng HongZhao YingjieHou XiaoliLing FangWang JingWang YixiaCao Yasen