CD146 _ MCAM Protein
- Known as:
- CD146 _ MCAM Protein
- Catalog number:
- 10115-H02H
- Product Quantity:
- 50
- Category:
- -
- Supplier:
- Smart Serology
- Gene target:
- CD146 _ MCAM Protein
Related genes to: CD146 _ MCAM Protein
- Gene:
- MCAM NIH gene
- Name:
- melanoma cell adhesion molecule
- Previous symbol:
- -
- Synonyms:
- MUC18, CD146, MelCAM, METCAM, HEMCAM
- Chromosome:
- 11q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 1995-12-18
- Date modifiied:
- 2019-04-16
Related products to: CD146 _ MCAM Protein
Related articles to: CD146 _ MCAM Protein
- Effects of trophic status on lake microeukaryote community dynamics remain underexplored. Spanning oligotrophic to hypereutrophic conditions, peri-urban lakes located in the Greater Paris region (France) offer unique opportunities to compare these dynamics along a eutrophication gradient. Here, community composition was characterised using 18S rRNA gene metabarcoding, and analyzed in the context of environmental parameters and chlorophyll a-derived trophic status throughout an 18-month sampling period. Microeukaryote assemblages were dominated by Cryptophyceae, Spirotrichea, Chrysophyceae, and Chlorophyceae, with mixotrophic and heterotrophic taxa dominating across all lakes. Taxa richness peaked at intermediate trophic levels, consistent with the intermediate disturbance hypothesis. Beta-diversity and network analyses revealed increasing community modularity, reduced connectivity, and enhanced temporal variability with higher trophic status. In lakes reaching the hypereutrophic status, communities diverged progressively over time. Conversely, oligo- to mesotrophic lakes maintained more connected and stable assemblages. These findings demonstrate that eutrophication fosters more diverse and increasingly divergent microeukaryote communities, underscoring its role as a central driver of microbial community restructuring in urban freshwater systems. - Source: PubMed
Duperron SébastienFoucault PierreVern Amaury LeGoto MidoliDuval CharlotteMarie BenjaminHamlaoui SahimaHalary SébastienLamy DominiqueLance EmilieTroussellier MarcBernard CécileJardillier LudwigLeloup Julie - Extracellular vesicles (EVs), including exosomes, are abundant in body fluids, and EV surface proteins can be profiled as potential minimally invasive biomarkers. CD147 (EMMPRIN/Basigin) is a tumor-associated surface glycoprotein implicated in cancer progression. CD9 and CD63 are tetraspanin membrane proteins widely used as EV markers. The present study aimed to evaluate the clinical significance of serum EV subsets double-positive for CD9 and CD63, or for CD9 and CD147 in patients with colorectal cancer (CRC) before and after tumor resection. - Source: PubMed
Adachi YukariMatsuda TakeruInubushi SachikoYasuda KeisukeIto RyotaShirakami NaotoTachibana TakaakiImai MasakiKagiyama HirokiTsuneki TakaoAndo MasayukiSaito MasafumiSugita YutakaIkeda TaroKoterazawa YasufumiAoki TomoakiHarada HitoshiOtowa YasunoriUrakawa NaokiGoto HironobuHasegawa HiroshiKanaji ShingoYamashita KimihiroHoffman Robert MKakeji Yoshihiro - Herein, we report a novel series of heterocyclic fluoro-methoxy-phenyl-substituted N-sulfonylpiperidine mono-spiro-1,2,4,5-tetraoxanes (5a-l; 50-93%) that have been successfully synthesised under metal-free and environmentally benign conditions. The inhibitory effects of all derivatives (5a-l) were determined in vitro on Plasmodium falciparum, Trypanosoma brucei, Mycobacterium, HeLa, and A2780 ovarian cancer cell cultures. The heterocyclic 1,2,4,5-tetraoxanes (5a-l; IC = 4.1-16.2 μM) displayed interesting micromolar antiplasmodial potential against chloroquine-resistant FcB1 strains of P. falciparum. Moreover, four representative analogues (5e, 5h, 5k, 5b) were evaluated in Danio rerio larvae, showing no lethality within the tested range, with sublethal morphological alterations observed at higher concentrations. As a result of a complex biological activity assessment, compounds with micromolar antiparasitic and antimycobacterial activities were identified, within an acceptable cytotoxicity range. Notably, the presented study constitutes the first evidence of a non-steroidal monomeric p-OCF-Ph-based 2-fluoro-p-OMe-phenyl ring-substituted N-sulfonylpiperidine mono-spiro-1,2,4,5-tetraoxane (5j; Pf FcB1 IC = 5.5 μM, Tbb IC = 25.6 μM, M. tuberculosis H37Ra MIC = 40 μM) exhibiting efficient multispecies-targeting susceptibilities. - Source: PubMed
Publication date: 2026/04/02
Tiwari Mohit KBakun PawelForest EmmaBola Jean-MichelMurias MarekKucinska MalgorzataZgoła-Grześkowiak AgnieszkaCicha EmiliaMarczak ŁukaszCavalier Jean-FranҫoisGrellier PhilippeGoslinski Tomasz - Here, solution NMR, gas-phase hydrogen/deuterium back-exchange (HDbX)-trapped ion mobility spectrometry (TIMS), electron capture dissociation (ECD), quantum mechanical (QM) calculations, and molecular dynamics (MD) simulations were combined for comprehensive structural elucidation of the lasso peptide syanodin I. NMR and ECD MS/MS confirmed an entangled lasso structure with Gln13 as the plug residue maintaining the lasso thread. A maximal /' ratio at Ala11 () was consistent with multiple long-range NOE correlations, identifying Ala11 in proximity to the macrolactam ring. ECD fragmentation patterns indicated a salt bridge between the C-terminus and the Gln13 side chain. TIMS resolved four distinct IMS bands for [M + 2H] ions of syanodin I and its branched-cyclic analog over a similar collision cross-sectional range. HDX-MS revealed mass shifts of ∼17 and ∼20 deuteriums for the lasso and branched-cyclic forms, respectively, consistent with the folded nature of the branched-cyclic C-terminal region. HDbX-TIMS-MS experiments ( ∼ 0.72 to ∼ 865 ms) resolved at least two distinct conformers within each IMS band, revealing intramolecular interactions inaccessible by TIMS alone. QM calculations determined the HDX rate and number of accessible hydrogens for Pro10 and Gln13; this information was used to inform the MD candidate assignment of the 2D-HDX-TIMS-MS results. This workflow provides a comprehensive framework for probing biomolecular conformational dynamics through complementary solution- and gas-phase approaches. The integration of solution-phase hydrogen/deuterium exchange (HDX) with ion mobility spectrometry-mass spectrometry (IMS-MS) offers powerful structural insights into the conformational dynamics of biological molecules. - Source: PubMed
Publication date: 2026/04/14
Santos-Fernandez MiguelJeanne Dit Fouque KevinKarki UkeshBlond AlainIdir RyaneAsgharihosseinpour NeginZirah SéverineChapagain PremMebel Alexander MHegemann Julian DFernandez-Lima Francisco - Although processing windows have been widely reported for LPBF Ti-6Al-4V, the distinct roles of laser power, scanning speed, and hatch distance remain unclear beyond VED-based comparisons. In this work, the distinct effects of laser power, scanning speed, and hatch distance on the microstructural evolution and mechanical response of laser powder bed fusion (LPBF) Ti-6Al-4V (Ti64) are investigated within a stable processing window with comparisons among different parameter combinations at a comparable VED. A total of 56 processing conditions were designed, and microstructure/texture and properties were characterized by OM/SEM, EBSD, microhardness (HV0.5), and hole-drilling residual stress measurements. Within the selected processing window, prior-β grain morphology, α' martensite thickness, texture, microhardness, and residual stress exhibit distinct sensitivities to different processing parameters. Specifically, lower scanning speeds and smaller hatch distances promote more continuous <001>β epitaxial growth, whereas higher scanning speeds or larger hatch distances produce fragmented prior-β grains. The α' lath thickness shows the strongest dependence on scanning speed with a secondary influence from hatch distance, while laser power mainly provides an overall thermal modulation. Furthermore, the macroscopic α (0002) texture is mainly governed by the β solidification texture, with α-variant selection playing a secondary, amplifying role. In addition, microhardness correlates with α' martensite thickness following a Hall-Petch equation. The peak residual stress is more sensitive to scanning speed, while bulk residual stress varies more significantly with hatch distance. These findings demonstrate that process parameters, in addition to VED, can guide microstructural control and mechanical optimization in LPBF Ti64 alloy. - Source: PubMed
Publication date: 2026/03/10
Shuai YuxinLiu JieZhu JingHuang ZhichaoZha WenhaoYang YiZhang RuifengZhang Kai