PVR _ CD155 _ NECL5 Protein
- Known as:
- PVR _ CD155 _ NECL5 Protein
- Catalog number:
- 10109-H02H
- Product Quantity:
- 100
- Category:
- -
- Supplier:
- Smart Serology
- Gene target:
- PVR _ CD155 NECL5 Protein
Related genes to: PVR _ CD155 _ NECL5 Protein
- Gene:
- PVR NIH gene
- Name:
- PVR cell adhesion molecule
- Previous symbol:
- PVS
- Synonyms:
- CD155, HVED, Necl-5, NECL5, Tage4
- Chromosome:
- 19q13.31
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-03-14
Related products to: PVR _ CD155 _ NECL5 Protein
Related articles to: PVR _ CD155 _ NECL5 Protein
- Adults with congenital heart disease affecting the right ventricular outflow tract often require repeated pulmonary valve replacements (PVR) throughout life, making prosthesis durability a critical determinant of long term outcomes. Bovine pericardial and porcine bioprosthetic valves are the most widely used in surgical PVR, yet comparative durability data remain inconsistent, partly due to reliance on nominal valve size rather than functional parameters. This study aimed to compare long term durability between both valves using indexed effective orifice area (iEOA) and analytic methods focused on prosthesis related performance. - Source: PubMed
Publication date: 2026/08/05
Pérez Nogales Eliú DavidReyes Elisabet VieraUrso StefanoPolo López María LuzTorres Maestro BlancaGonzález-Martín Jesús MaríaColunga Pablo MerasCantador Jose RuízMerino Argos Carlos - Ocular diseases, such as neovascular age-related macular degeneration (nAMD) and proliferative vitreoretinopathy (PVR), have a fibrotic component that negatively impacts vision. Unfortunately, few treatments are available to mitigate fibrosis in the eye. The clearance of inflammatory cells proceeds, at least in part, through the intrinsic cell death pathway in which Bcl-2 family members play integral roles. Here, we assessed the influence of Bcl-2 expression in mononuclear phagocytes (MP) on the engagement and clearance of inflammatory cells, choroidal neovascularization (CNV), and subsequent subretinal fibrosis in a mouse laser-induced CNV model. Lack of Bcl-2 expression in MP (Bcl-2 mice) decreased neutrophil (Gr1) and microglia (Iba1) presence without impacting M1 (CD80) and M2 (CD206) macrophage presence, CNV, or fibrosis during the first 2 weeks following laser photocoagulation. Later, after inflammation dampens, decreased later-stage fibrosis and CNV were noted in Bcl-2 mice, which were accompanied by increased presence of M2 macrophages (CD206). However, how these increased levels of CD206 M2 macrophages in the absence of Bcl-2 contribute to decreased CNV and fibrosis remains unknown. To address whether Bcl-2 expression affects other forms of ocular fibrosis, we utilized the dispase PVR model. Bcl-2 mice, or treatment of wild-type mice with Bcl-2 inhibitors, significantly decreased fibrosis in the PVR model. Furthermore, Bcl-2 inhibitors mitigated CNV and fibrosis (collagen I-defined) in wild-type mice during laser photocoagulation. Thus, inhibition of Bcl-2 activity prevents the late-stage clearance of CD206 M2 macrophages during nAMD and PVR, mitigating ocular neovascularization and fibrosis. - Source: PubMed
Publication date: 2026/08/20
Song Yong-SeokWang ShoujianDarjatmoko Soesiawati RSheibani NaderSorenson Christine M - Pulmonary vascular diseases are characterized by mean pulmonary artery pressure (mPAP) and pulmonary vascular resistance (PVR), both reflecting the steady-flow component of right ventricular (RV) afterload while neglecting pulsatile elements. Pulmonary artery compliance (PAC) and arterial elastance (E) capture complementary aspects of pulmonary vascular load, whereas stroke volume index (SVI) reflects RV functional adaptation. The prognostic significance of these integrated parameters remains incompletely understood, particularly in early-stage disease. - Source: PubMed
Publication date: 2026/08/26
Yogeswaran AthiththanFünderich MeikeKiely David GAnnis Jeffrey SBrittain EvanBogaard Harm JanBalasubramanian AparnaHassoun Paul MHoward LukeLawrie AllanWilkins Martin RThenappan ThenappanElwing JeanJose ArunLichtblau MonaUlrich SilviaHarbaum LarsKlose HansSweatt Andrew JZamanian Roham TLau Edmund MKuronuma KeiichiroMatsubara HiromiDwyer NathanSirenko YuriyTorbas OlenaEichstaedt Christina AGrünig EkkehardLavender MelanieArvanitaki AlexandraGiannakoulas GeorgeFrauendorf MarlizeWilliams Paul GZhai ZhenguoZhang ZhuAnthi AnastasiaDima EffrosyniSabbour HaniSaleh KhaledGhio StefanoScelsi LauraDe Luque Figueroa JulianaOrozco-Levi MauricioRamirez-Sarmiento AlbaSivakumaran SivaAnderson JamesChan Stephen YKing IngridOlschewski HorstGhofrani Hossein-ArdeschirGrimminger FriedrichMajeed Raphael WWilhelm JochenTello KhodrSeeger Werner - Patients with D-transposition of the great arteries (TGA) often require prostaglandin E1 (PGE) even after balloon atrial septostomy (BAS). This study builds a computer simulation that analyzes whether or not elevated pulmonary vascular resistance (PVR) could explain the profound hypoxemia seen in some patients after PGE discontinuation. - Source: PubMed
Publication date: 2026/08/04
Savorgnan FabioFlores SaulGarcia-Mancebo JuliaHassan AdelLoomba Rohit SAcosta Sebastian - To examine the effectiveness and safety of adjunctive intravitreal methotrexate (MTX) in enhancing morphological and functional results following pars plana vitrectomy (PPV) in eyes affected by rhegmatogenous retinal detachment (RRD) accompanied by proliferative vitreoretinopathy (PVR). - Source: PubMed
Publication date: 2026/08/26
Mohamed Elsayed Saad EhabElbadry Mohammed Mohammed HazemDabour Sherif AAlyan Ahmed