CNDP1 Protein
- Known as:
- CNDP1 Protein
- Catalog number:
- 10077-H03H
- Product Quantity:
- 20
- Category:
- -
- Supplier:
- Smart Serology
- Gene target:
- CNDP1 Protein
Related genes to: CNDP1 Protein
- Gene:
- CNDP1 NIH gene
- Name:
- carnosine dipeptidase 1
- Previous symbol:
- -
- Synonyms:
- MGC10825, CN1, CPGL2, HsT2308
- Chromosome:
- 18q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-04-14
- Date modifiied:
- 2016-05-20
Related products to: CNDP1 Protein
Related articles to: CNDP1 Protein
- Tea consumption may be associated with skeletal muscle health, but longitudinal evidence based on repeated assessments remains limited. We examined the associations of tea intake and serum biomarkers with repeated skeletal muscle measures and explored whether these associations might be partly explained by multi-omics features. In this prospective cohort, 3408 adults were followed for approximately 12 years. Skeletal muscle mass was measured by dual-energy X-ray absorptiometry, handgrip strength by digital dynamometry, gut microbial taxonomic and functional profiles by shotgun metagenomic sequencing, serum proteins by data-independent acquisition mass spectrometry, and fecal metabolites by targeted UPLC-MS/MS metabolomics. Linear mixed-effects models examined longitudinal associations, and mediation analyses estimated indirect effects. In longitudinal analyses, higher tea consumption frequency was associated with greater appendicular skeletal muscle mass, appendicular skeletal muscle index, and handgrip strength (β: 0.037-0.140; 95% CI: 0.002-0.205). Higher circulating flavan-3-ols showed similar associations with these muscle-related outcomes (β: 0.085-0.174; 95% CI: 0.007-0.254), whereas no significant associations were observed with walking speed. Exploratory multi-omics analyses identified tea-related differences in gut microbial species and functional pathways, fecal metabolites, and circulating proteins, including Gemmiger formicilis, amino acid biosynthesis pathways, fructose 1,6-bisphosphate, VTN, CFI, CNDP1, and ITIH4. Exploratory mediation analyses identified statistical indirect associations involving multi-omics features, with estimated proportions mediated ranging from 4.5% to 19.0%. Overall, higher tea consumption and circulating biomarkers were associated with greater skeletal muscle mass and strength, accompanied by distinct multi-omics features that may provide potential biological links between tea exposure and muscle-related outcomes. - Source: PubMed
Publication date: 2026/08/14
Hong ZhenLu ZilongShi RuiqiZheng SitingLuo JielingChen JuXie ZhiyongZheng Ju-ShengChen Yu-MingZhang Zheqing - Hepatocellular Carcinoma (HCC) is a malignant tumor originating from hepatocytes. Hirsutanonol is a secondary metabolite derived from the bark of Alnus japonica that has multiple biological activities, including anti-inflammatory, antioxidant, and antitumor effects. However, its role and underlying mechanism in hepatocellular carcinoma remain unclear. This study aimed to explore the effects of Hirsutanonol on HCC cells and its related molecular mechanism. - Source: PubMed
Publication date: 2026/07/27
Du YouwenWang XiaoXiao YueyueYang ZhengxiYi JingyuXie ZihangFeng JinxuanHao XingyunZhu JiajunWang HaichuanWang ShuominPan Linxin - Diabetic kidney disease (DKD) affects a substantial proportion of individuals with diabetes mellitus and represents the leading cause of end-stage renal disease worldwide. Familial aggregation studies consistently demonstrate that genetic factors contribute significantly to DKD susceptibility beyond metabolic and hemodynamic determinants. The carnosine dipeptidase 1 () gene on chromosome 18q22.3 has emerged as a compelling susceptibility locus, with a trinucleotide (CTG) repeat polymorphism in exon 2 that encodes the Mannheim variant, which has demonstrated protective associations in selected populations. Individuals homozygous for the shorter (CTG) allele exhibit reduced serum carnosinase-1 concentrations and activity, resulting in elevated tissue carnosine levels. Carnosine exerts multiple renoprotective effects, including antioxidant activity, inhibition of advanced glycation end-product formation, and attenuation of profibrotic signaling. Experimental models demonstrate that genetic or pharmacological reduction in carnosinase activity attenuates diabetic kidney injury. Early clinical studies of carnosine supplementation report improvements in albuminuria and oxidative stress markers, though available trials are limited in size, duration, and population scope. Therapeutic targeting of via carnosinase inhibition, therefore, represents a biologically grounded yet still emerging pharmacological strategy. This review synthesizes genetic, molecular, and translational evidence supporting as a model for genetics-informed therapeutic development in DKD, while highlighting important population-specific variation in allele frequencies that constrain universal clinical applicability. - Source: PubMed
Publication date: 2026/03/24
Delibasi Bulent TolgaSarisen Michael IsmailBelitsos Matthew ThomasErol Halil KutluDelibasi Tuncay - Homozygous carriers of the CNDP1 (CTG)5 allele with diabetes mellitus are believed to have a lower risk of developing diabetic kidney disease compared to individuals carrying alleles with higher numbers of this CTG repeat. However, recent studies claimed that homozygosity for the (CTG)5 allele increases the risk of disease progression towards end-stage renal disease and even cardiovascular mortality, at least in women. Therefore, this study sought to confirm in a prospective manner in a cardiovascular high-risk cohort if individuals with two (CTG)5 alleles indeed have an increased cardiovascular mortality. 3,201 individuals from the LURIC study were included and followed for a median of 9.9 years. CNDP1 (CTG)n genotypes were assessed and related to all-cause and cardiovascular mortality. 1,157 (36.1%) patients carried the homozygous CNDP1 (CTG)5 genotype. No significant difference for all-cause and cardiovascular mortality was detected after multiple adjustments for cardiovascular risk factors, neither for the whole cohort nor for men or women, respectively. In this prospective cardiovascular high-risk cohort, homozygosity for the CNDP1 (CTG)5 allele was not associated with increased cardiovascular mortality compared to all other genotypes together. These findings do not confirm previous reports suggesting a sex-specific increase in cardiovascular mortality among women carrying two (CTG)5 alleles. - Source: PubMed
Publication date: 2026/04/21
Hettler Steffen AMoissl AngelaDelgado Graciela ESkladny HeykoMärz WinfriedKrämer Bernhard KYard Benito AKleber Marcus E - Duck meat is highly appreciated for its unique flavor and rich nutritional value, and metabolites have become important phenotypic indicators of meat quality. The Sansui duck, a celebrated local breed from Guizhou, is known for its tender, savory meat, yet its metabolomic composition and underlying genetic basis remain unexplored. In our study, non-targeted LC-MS/MS metabolomics of 305 Sansui duck breast muscles detected 4,729 metabolic features (459 annotated) and identified 136 sex-differential metabolites enriched in fatty acid and amino acid metabolism pathways. Metabolite-based genome-wide association studies (mGWAS) further identified 355 significant LD-independent SNPs and 267 potential candidate genes associated with 103 metabolites. The signal peaks for amino acid metabolites were mainly concentrated on chromosomes 1, 5, and 20. A QTL on chromosome 2 (63.90-64.10 Mb), containing candidate genes ZNF407, CNDP1, and CNDP2, was identified for three methylglyoxal derivatives, with the lead SNP (chr2: 63928783) accounting for about 18.3 % of their variance. Additional QTLs on chromosomes 5, 20, 1, and 24 were associated with Carnosine, N-Acetylhistidine, Acetylcholine, N-Acetyl-L-aspartic acid, 11b-PGF2a, and 12(S)-HpETE. These intervals harbor BBOX1 and ACACA, two key rate-limiting enzymes in fatty acid metabolism. Our results revealed the genetic basis of breast muscle metabolites in Sansui ducks and identified associated genetic loci and candidate genes. These findings deepen our understanding of muscle metabolism and provide valuable insights for improving meat quality and nutritional breeding. - Source: PubMed
Publication date: 2026/03/18
Feng YulongXu MengruYu XintongYang ZhaoQi JingjingXi YangGuo ShihaoHan XuLi MeijuanLu YuxiDai GuotaoTian ChengchengZhao YuHuang AnqiLi LiangLiu Hehe