CNDP1 Protein
- Known as:
- CNDP1 Protein
- Catalog number:
- 10077-H03H
- Product Quantity:
- 20
- Category:
- -
- Supplier:
- Smart Serology
- Gene target:
- CNDP1 Protein
Related genes to: CNDP1 Protein
- Gene:
- CNDP1 NIH gene
- Name:
- carnosine dipeptidase 1
- Previous symbol:
- -
- Synonyms:
- MGC10825, CN1, CPGL2, HsT2308
- Chromosome:
- 18q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-04-14
- Date modifiied:
- 2016-05-20
Related products to: CNDP1 Protein
Related articles to: CNDP1 Protein
- To elucidate the molecular characteristics of synergistic interactions across the clinical stages of coronary heart disease (CHD)-specifically stable angina pectoris (SAP), unstable angina pectoris (UAP), and acute myocardial infarction (AMI)-through integrated metabolomic and proteomic analyses. Based on a cohort including SAP, UAP, AMI, and healthy controls, metabolomic and proteomic analyses were performed to identify differentially expressed molecules, followed by KEGG pathway enrichment analysis. Pathways co-enriched across both omics platforms were selected to construct metabolite-protein interaction networks. The number of pathways co-enriched in both metabolomic and proteomic analyses increased markedly with disease stage. Only two pathways (histidine metabolism and arginine and proline metabolism) were identified in the SAP stage; this number increased to five in the UAP stage (including ferroptosis and efferocytosis) and expanded to 25 in the AMI stage, encompassing three major functional modules: immune inflammation, metabolic reprogramming, and cell signaling. The core network exhibited a stepwise increase in connectivity, shifting from a sparse structure in the SAP stage to a highly interconnected architecture in the AMI stage, with L-glutamate and KNG1 identified as the central hubs in this cross-sectional network. In addition, CNDP1 exhibited a stage-dependent functional transition, shifting from downregulation in SAP to upregulation in AMI. In this cross-sectional analysis, metabolic dysregulation and immune activation exhibited stepwise increases in interconnectivity across the SAP, UAP, and AMI groups, with the most extensive crosstalk observed in the AMI stage-a network configuration consistent with a tightly coupled "molecular storm". These findings provide novel insights into stage-associated molecular signatures of CHD and identify candidate hub molecules for stage-oriented therapeutic investigation. - Source: PubMed
Publication date: 2026/08/12
Tan XilunGao YuanxiaoxueWang JiaWang XuesenPan YishuangChen MingyuGao MeiliZhang MingZhang ChenhaoDing Pinsheng - Tea consumption may be associated with skeletal muscle health, but longitudinal evidence based on repeated assessments remains limited. We examined the associations of tea intake and serum biomarkers with repeated skeletal muscle measures and explored whether these associations might be partly explained by multi-omics features. In this prospective cohort, 3408 adults were followed for approximately 12 years. Skeletal muscle mass was measured by dual-energy X-ray absorptiometry, handgrip strength by digital dynamometry, gut microbial taxonomic and functional profiles by shotgun metagenomic sequencing, serum proteins by data-independent acquisition mass spectrometry, and fecal metabolites by targeted UPLC-MS/MS metabolomics. Linear mixed-effects models examined longitudinal associations, and mediation analyses estimated indirect effects. In longitudinal analyses, higher tea consumption frequency was associated with greater appendicular skeletal muscle mass, appendicular skeletal muscle index, and handgrip strength (β: 0.037-0.140; 95% CI: 0.002-0.205). Higher circulating flavan-3-ols showed similar associations with these muscle-related outcomes (β: 0.085-0.174; 95% CI: 0.007-0.254), whereas no significant associations were observed with walking speed. Exploratory multi-omics analyses identified tea-related differences in gut microbial species and functional pathways, fecal metabolites, and circulating proteins, including Gemmiger formicilis, amino acid biosynthesis pathways, fructose 1,6-bisphosphate, VTN, CFI, CNDP1, and ITIH4. Exploratory mediation analyses identified statistical indirect associations involving multi-omics features, with estimated proportions mediated ranging from 4.5% to 19.0%. Overall, higher tea consumption and circulating biomarkers were associated with greater skeletal muscle mass and strength, accompanied by distinct multi-omics features that may provide potential biological links between tea exposure and muscle-related outcomes. - Source: PubMed
Publication date: 2026/08/14
Hong ZhenLu ZilongShi RuiqiZheng SitingLuo JielingChen JuXie ZhiyongZheng Ju-ShengChen Yu-MingZhang Zheqing - Hepatocellular Carcinoma (HCC) is a malignant tumor originating from hepatocytes. Hirsutanonol is a secondary metabolite derived from the bark of Alnus japonica that has multiple biological activities, including anti-inflammatory, antioxidant, and antitumor effects. However, its role and underlying mechanism in hepatocellular carcinoma remain unclear. This study aimed to explore the effects of Hirsutanonol on HCC cells and its related molecular mechanism. - Source: PubMed
Publication date: 2026/07/27
Du YouwenWang XiaoXiao YueyueYang ZhengxiYi JingyuXie ZihangFeng JinxuanHao XingyunZhu JiajunWang HaichuanWang ShuominPan Linxin - Diabetic kidney disease (DKD) affects a substantial proportion of individuals with diabetes mellitus and represents the leading cause of end-stage renal disease worldwide. Familial aggregation studies consistently demonstrate that genetic factors contribute significantly to DKD susceptibility beyond metabolic and hemodynamic determinants. The carnosine dipeptidase 1 () gene on chromosome 18q22.3 has emerged as a compelling susceptibility locus, with a trinucleotide (CTG) repeat polymorphism in exon 2 that encodes the Mannheim variant, which has demonstrated protective associations in selected populations. Individuals homozygous for the shorter (CTG) allele exhibit reduced serum carnosinase-1 concentrations and activity, resulting in elevated tissue carnosine levels. Carnosine exerts multiple renoprotective effects, including antioxidant activity, inhibition of advanced glycation end-product formation, and attenuation of profibrotic signaling. Experimental models demonstrate that genetic or pharmacological reduction in carnosinase activity attenuates diabetic kidney injury. Early clinical studies of carnosine supplementation report improvements in albuminuria and oxidative stress markers, though available trials are limited in size, duration, and population scope. Therapeutic targeting of via carnosinase inhibition, therefore, represents a biologically grounded yet still emerging pharmacological strategy. This review synthesizes genetic, molecular, and translational evidence supporting as a model for genetics-informed therapeutic development in DKD, while highlighting important population-specific variation in allele frequencies that constrain universal clinical applicability. - Source: PubMed
Publication date: 2026/03/24
Delibasi Bulent TolgaSarisen Michael IsmailBelitsos Matthew ThomasErol Halil KutluDelibasi Tuncay - Homozygous carriers of the CNDP1 (CTG)5 allele with diabetes mellitus are believed to have a lower risk of developing diabetic kidney disease compared to individuals carrying alleles with higher numbers of this CTG repeat. However, recent studies claimed that homozygosity for the (CTG)5 allele increases the risk of disease progression towards end-stage renal disease and even cardiovascular mortality, at least in women. Therefore, this study sought to confirm in a prospective manner in a cardiovascular high-risk cohort if individuals with two (CTG)5 alleles indeed have an increased cardiovascular mortality. 3,201 individuals from the LURIC study were included and followed for a median of 9.9 years. CNDP1 (CTG)n genotypes were assessed and related to all-cause and cardiovascular mortality. 1,157 (36.1%) patients carried the homozygous CNDP1 (CTG)5 genotype. No significant difference for all-cause and cardiovascular mortality was detected after multiple adjustments for cardiovascular risk factors, neither for the whole cohort nor for men or women, respectively. In this prospective cardiovascular high-risk cohort, homozygosity for the CNDP1 (CTG)5 allele was not associated with increased cardiovascular mortality compared to all other genotypes together. These findings do not confirm previous reports suggesting a sex-specific increase in cardiovascular mortality among women carrying two (CTG)5 alleles. - Source: PubMed
Publication date: 2026/04/21
Hettler Steffen AMoissl AngelaDelgado Graciela ESkladny HeykoMärz WinfriedKrämer Bernhard KYard Benito AKleber Marcus E