4_1BB _ CD137 _ TNFRSF9 Protein
- Known as:
- 4_1BB _ CD137 _ TNFRSF9 Protein
- Catalog number:
- 10041-H03H
- Product Quantity:
- 50
- Category:
- -
- Supplier:
- Smart Serology
- Gene target:
- 4_1BB _ CD137 TNFRSF9 Protein
Related genes to: 4_1BB _ CD137 _ TNFRSF9 Protein
- Gene:
- TNFRSF9 NIH gene
- Name:
- TNF receptor superfamily member 9
- Previous symbol:
- ILA
- Synonyms:
- CD137, 4-1BB
- Chromosome:
- 1p36.23
- Locus Type:
- gene with protein product
- Date approved:
- 1996-06-12
- Date modifiied:
- 2016-10-05
Related products to: 4_1BB _ CD137 _ TNFRSF9 Protein
Related articles to: 4_1BB _ CD137 _ TNFRSF9 Protein
- Nasopharyngeal carcinoma (NPC), highly prevalent in southern China, often leads to treatment failure in advanced stages due to recurrence or metastasis. While METTL14 plays a crucial role in cancer, its regulation of immune- and inflammation-related genes remains poorly understood. This study aims to investigate whether METTL14 is involved in regulating the expression of genes associated with tumor necrosis factor (TNF), interferon (IFN), interleukin (IL), and MHC class I in NPC cells. - Source: PubMed
Zhou ZhihaoWang JingShen LingjunHan LiuxinLi QiwenWu AibingLi JingLiang ZumingZhu LitongHe DanhuaZhou YingHuang ShihaoZhao ZhanlinCong JingePeng ZhitaoZhao PingYe ShunaBai BinyiHong XuanjiaDai GuanqiLei YeZhao WentaoJia JunshuangLin XiaolinXiao DongZhang YuqinLin Taoyan - Human membrane-bound CD137 (mCD137) is a well-known costimulatory molecule; however, it is alternatively spliced into two transcripts (sCD137-1, 2) whose function is not yet known. Here, we show that sCD137 isoforms lack the CRD4 region and form unique structures compared to mCD137. Human activated Tregs produce both CD137 splice isoforms, which are rapidly upregulated after cell activation, and identify an activated Treg phenotype along with FOXP3, CTLA4, and sCTLA4. We engineered recombinant Fc-Hu-sCD137 variants, which are immunosuppressive, inhibiting IFN-γ secretion and proliferation in purified CD4 and CD8 T cells in an APC-independent manner. These effects are mediated by the downregulation of S6 and 4EBP1 of the mTOR complex 1 pathway. Human sCD137 variants, in contrast to the membrane-bound form, are immunosuppressive and may be a novel treatment for inflammation and autoimmunity. - Source: PubMed
Publication date: 2025/11/07
Rojas ManuelHeuer Luke SZhang WeiciSweeney NicolleRamírez-Santana CarolinaLeung Patrick S CLam AlvinKamat ShraddhaMendelsohn Andrew RHuang ManleyYu BoAckerman PaulinaWei QishengLarrick James WChen Yi-GuangRidgway William M - This study aimed to investigate the role of Collagen triple helix repeat protein 1 (CTHRC1) in Wilms' tumor (WT) progression and elucidate its molecular mechanism in promoting WT malignancy through regulation of M2-type tumor-associated macrophages (M2-TAMs) infiltration and polarization. - Source: PubMed
Publication date: 2025/07/08
Zhuo YingquanFeng XiaoyunZhang WenqiDu JunSun XuLuo XiWang WeiJiang HuaGu Huajian - Owing to the desmoplastic stroma constituted by cancer-associated fibroblasts (CAFs), few immune cells infiltrate the pancreatic ductal adenocarcinoma (PDAC). Gabapentin can impede the production of ketoacids by CAFs to support cancer cells. However, in our study, we discovered a dose-dependent increase in transforming growth factor β1 (TGF-β1) levels in cancer cells in response to gabapentin. This reverse increase of TGF-β1 contributes to 'Gabapentin-resistance', leading to the antitumor effects on PDAC cell lines are negatively negotiated in the presence of pancreatic stellate cells. Pirfenidone synergistically inhibited the growth and apoptosis resistance of PDAC when combined with Gabapentin. In a mouse orthotopic PDAC model, Fe-mediated coordination nanodrugs, which contain gabapentin, pirfenidone and the natural polyphenol (EGCG), efficiently promoted the infiltration of naïve CD8 T cells (CD44CD62L) and the accumulation of inflammatory CAFs (α-SMAIL-6). This led to a nearly two-fold increase in survival compared to the control. Furthermore, we identified a new subpopulation as Hmox1iCAFs following treatment with our nanodrugs. Hmox1iCAFs overexpressed the Cxcl10 receptor (Sdc4) and facilitated functional CD8 T-cell infiltration through the Tnfsf9-Tnfrsf9 axis. Overall, our nanodrugs reshape the phenotype of CAFs and enhance functional CD8 T-cell infiltration into tumors, holding the potential to be a safe and promising therapy for PDAC. - Source: PubMed
Publication date: 2024/10/09
Zhang JinZhang JunrongLin RongguiHou PingZheng LihongJiang ChenweiZhang DaHuang HeguangTeng Tianhong - To establish a prognostic model based on immune-related microRNA (miRNA) for pancreatic carcinoma. Weighted correlation network analysis (WGCNA) was performed using the "WGCNA" package to find the key module genes involved in pancreatic carcinoma. Spearman correlation analysis was conducted to screen immune-related miRNAs. Uni- and multi-variate COX regression analyses were carried out to identify miRNAs prognostic for overall survival (OS) of pancreatic carcinoma, which were then combined to generate a prognostic model. Kaplan-Meier survival analysis, receiver operating characteristic (ROC) analysis, distribution plot of survival status in patients and regression analysis were collectively performed to study the accuracy of the model in prognosis. Target genes of the miRNAs in the model were intersected with the key module genes, and a miRNA-mRNA network was generated and visualized by Cytoscape3.8.0. TIMER analysis was conducted to study the abundance of immune infiltrates in tumor microenvironment of pancreatic carcinoma. Expression levels of immune checkpoint genes in subgroups stratified by the model were compared by Wilcoxon test. Gene Set Enrichment Analysis (GSEA) was performed to analyze the enriched signaling pathways between subgroups. Differential analysis revealed 1826 genes differentially up-regulated in pancreatic carcinoma and 1276 genes differentially down-regulated. A total of 700 immune-related miRNAs were obtained, of which 7 miRNAs were significantly associated with OS of patients and used to establish a prognostic model with accurate predictive performance. There were 99 mRNAs overlapped from the 318 target genes of the 7 miRNAs and the key modules genes analyzed by WGCNA. Patient samples were categorized as high or low risk according to the prognostic model, which were significantly associated with dendritic cell infiltration and expression of immune checkpoint genes (TNFSF9, TNFRSF9, KIR3DL1, HAVCR2, CD276 and CD80). GSEA showed remarkably enriched signaling pathways in the two subgroups. This study identified an immune-related 7-miRNA based prognostic model for pancreatic carcinoma, which could be used as a reliable tool for prognosis. - Source: PubMed
Publication date: 2022/09/02
Shen QianLi JunChenPan XueZhang ChuanLongJiang XiaoChenLi YiChen YanPang Bo