NRP1 _ Neuropilin_1 Protein
- Known as:
- NRP1 _ Neuropilin_1 Protein
- Catalog number:
- 10011-H02H
- Product Quantity:
- 50
- Category:
- -
- Supplier:
- Smart Serology
- Gene target:
- NRP1 _ Neuropilin_1 Protein
Related genes to: NRP1 _ Neuropilin_1 Protein
- Gene:
- NRP1 NIH gene
- Name:
- neuropilin 1
- Previous symbol:
- -
- Synonyms:
- NRP, VEGF165R, CD304
- Chromosome:
- 10p11.22
- Locus Type:
- gene with protein product
- Date approved:
- 1998-12-23
- Date modifiied:
- 2016-10-05
Related products to: NRP1 _ Neuropilin_1 Protein
Related articles to: NRP1 _ Neuropilin_1 Protein
- Plasmacytoid dendritic cells (pDCs) have been implicated in both restraining and promoting intrahepatic cholangiocarcinoma (iCCA), leaving their clinical relevance and therapeutic potential unresolved. - Source: PubMed
Publication date: 2026/07/28
Chen Mei-RuXie Xiao-LiZhou Yan-LiTian Jin-MeiZhao YingHou SupingWang Yuan-YuanLu Ji-ChaoZhao Dong-QiangCui Zhao-BoZhang Li-Xian - This study aimed to investigate the modulatory function of microRNA-1246 (miR-1246) in the odontogenic differentiation of human dental pulp stem cells (hDPSCs) under inflammatory conditions in vitro and to elucidate its underlying molecular mechanism. - Source: PubMed
Publication date: 2026/09/17
Wu ShunyingWang YueyanYang Jiayi - Mechanisms of systemic administration of cytotoxic and immunomodulatory agents are hindered due to poor intratumoral retention and off-target toxicities. While Antibody-Drug Conjugates (ADCs) have achieved substantial clinical success and validated the paradigm of targeted therapy, their large size (∼150 kDa) limits their ability to cross blood vessels and interstitial spaces, especially in the dense, collagen-rich stroma of aggressive solid tumors. As a smaller alternative for drug delivery, Tumor-Homing Peptides (THPs) allow for improved tissue permeability, low immunogenicity and rapid systemic clearance. Here, we examine THPs discovery and development trajectory, from phage display strategies to current deep learning-driven design methodologies. We analyze the structural and functional biology of the predominant internalization pathways like the Neuropilin-1 (NRP-1) dependent C-end Rule (CendR) and the Sortilin (SORT1) scavenger receptor, and their use to promote deep tissue penetration. Finally, we assess the translational landscape of early 2026, including the recent FDA withdrawal of the lipophilic peptide-conjugated melphalan flufenamide (Pepaxto®) and the recent clinical success of the cyclic peptide certepetide for pancreatic adenocarcinoma and the ongoing promising studies with chemically constrained bicyclic peptides. - Source: PubMed
Publication date: 2026/09/16
Ma GuojunDerkaoui Dalia KheiraSenhadji RachidKaroyan PhilippePoyet Jean-Luc - Neuropilin-1 (NRP1) is a developmentally conserved cell surface receptor that functionally acts to bind various ligands like class 3 semaphorins and several members of the VEGF family to engage in different signaling pathways that control cell migration and motility. Due to its widespread expression, NRP1 is implicated in immune function, axonal guidance, viral entry, tumor progression and angiogenesis. NRP1 is dysregulated across multiple cancer types and promotes tumor progression in a context-dependent manner in tumor cells and the tumor microenvironment, including endothelial, stromal, and immune-cell compartments. NRP1 is also involved in different autoimmune disorders, anosmia, and cardiovascular disorders. Phage display studies revealed that peptides containing C-terminal CendR motifs engage NRP1 for tissue penetration. Apart from cell-penetrating peptides, monoclonal antibodies against NRP1 also present a promising target for cancer therapeutics. Importantly, NRP1 in SARS-CoV-2 infection act as an auxiliary host factor, and furin cleavage of the viral spike protein exposes a C-terminal CendR motif that can bind NRP1, thereby facilitating viral entry. However, NRP1 is not an independent receptor comparable to ACE2, thus, NRP1-targeted antiviral strategies need further investigations. Given the above, the review provides comprehensive narrative of different signaling mechanisms of NRP1 in different diseases and how this cell surface receptor can be utilized in various therapeutic approaches to combat these diseases. - Source: PubMed
Publication date: 2026/09/15
Aashaq SabreenaRakhshan RabiaRafiq AsmaAli MahvishBeigh Mushtaq A - To investigate the association between serum extracellular vesicle-derived neuropilin-1 (EV NRP1) and endothelial dysfunction in patients with type 2 diabetes mellitus (T2DM). - Source: PubMed
Publication date: 2026/09/11
Cui ZhengshuoZhang ZihangLi XinxinLiu YangZhou WeiweiGuo HanTang JieqiongZeng ZhechunYuan HuiHu RongTao HongLi LinghaiZhang Huina