VEGF121 _ VEGF_A Protein (Native)
- Known as:
- VEGF121 _ VEGF_A Protein (Native)
- Catalog number:
- 10008-HNAB
- Product Quantity:
- 20
- Category:
- -
- Supplier:
- Smart Serology
- Gene target:
- VEGF121 _ VEGF_A Protein (Native)
Related genes to: VEGF121 _ VEGF_A Protein (Native)
- Gene:
- VEGFA NIH gene
- Name:
- vascular endothelial growth factor A
- Previous symbol:
- VEGF
- Synonyms:
- VEGF-A, VPF
- Chromosome:
- 6p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1994-01-10
- Date modifiied:
- 2016-10-05
Related products to: VEGF121 _ VEGF_A Protein (Native)
Related articles to: VEGF121 _ VEGF_A Protein (Native)
- Endometriosis is a chronic gynecological disease characterized by the presence of endometrial tissue outside the uterine cavity, affecting approximately 10% of women of reproductive age. Vascular endothelial growth factor (VEGF) and cancer antigen 125 (CA125) have been proposed as potential biomarkers in endometriosis; however, evidence regarding their association with disease stage and pain severity remains limited, particularly in the Indonesian population. The aim of this study was to evaluate the relationship between peritoneal fluid VEGF and serum CA125 levels with endometriosis stage and pain severity. A cross-sectional study was conducted involving patients with surgically and histopathologically confirmed endometriosis who underwent laparoscopy or laparotomy at Dr. Zainoel Abidin Hospital, Banda Aceh, between February and July 2025. Peritoneal fluid VEGF and serum CA125 levels were measured using enzyme-linked immunosorbent assay and chemiluminescence immunoassay, respectively. Endometriosis stage was classified according to the revised American Society for Reproductive Medicine (rASRM) criteria, and pain severity was assessed using the Numeric Rating Scale. Statistical analyses included Spearman's correlation and receiver operating characteristic (ROC) curve analysis. Our data suggested no significant correlation between VEGF levels and endometriosis stage ( = 0.042; = 0.813). Peritoneal fluid VEGF levels showed a moderate positive correlation with pain severity ( = 0.505; < 0.05), and ROC analysis identified an optimal cut-off value of 39.45 pg/mL, with a sensitivity of 73.68% and specificity of 73.33% for distinguishing severe pain from mild-to-moderate pain. Serum CA125 levels demonstrated a significant positive correlation with endometriosis stage ( = 0.422; = 0.013), and ROC analysis yielded an optimal cut-off value of 32.45 U/mL, with a sensitivity of 86.95% and a specificity of 63.64% for distinguishing stage IV endometriosis from lower stages. No significant correlation was observed between CA125 levels and pain severity ( = 0.186; = 0.292). This study represents the first report from Indonesia to simultaneously evaluate peritoneal fluid VEGF and serum CA125 in relation to endometriosis stage and pain severity. This study highlights that CA125 is primarily associated with endometriosis stage, whereas VEGF is more closely related to pain severity, supporting their complementary roles in endometriosis assessment. - Source: PubMed
Publication date: 2026/01/19
Sujudi AkmalRusnaidi RusnaidiDewi Tgk PuspaRajuddin RajuddinSeptivera Yusra - Endometriosis affects approximately 10-15% of reproductive-age women and up to 70% of those with chronic pelvic pain, with diagnosis typically relying on invasive laparoscopy with histopathological confirmation. Cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) are central mediators of the inflammatory and angiogenic pathways underpinning endometriosis pathogenesis, making them promising candidates for non- invasive biomarkers. This study aimed to analyze the correlation between serum COX-2 and VEGF concentrations and endometriosis severity to evaluate their potential utility as non-invasive biomarkers. A cross-sectional study was conducted among women with confirmed endometriosis at Dr. Zainoel Abidin General Hospital in Banda Aceh, Indonesia, in 2025. Peripheral blood samples were collected preoperatively, and serum COX-2 and VEGF concentrations were quantified using ELISA. Endometriosis severity was classified according to the American Society for Reproductive Medicine staging system. Correlation analyses were performed to assess associations between biomarker levels and disease stage, and diagnostic performance was evaluated using receiver operating characteristic (ROC) curve analysis to determine the area under the curve (AUC) values, optimal cut-off points, sensitivity, and specificity. Twenty-eight patients were included, with the mean COX-2 and VEGF levels being 1.16 ± 1.28 ng/mL and 266.50 ± 72.91 pg/mL, respectively. VEGF demonstrated a strong and statistically significant correlation with endometriosis staging ( = 0.744, < 0.001), while COX-2 showed a limited correlation that did not reach statistical significance ( = 0.367, = 0.055). The ROC analysis further highlighted VEGF's superior diagnostic performance, with an AUC of 0.975 (95%CI: 0.926-1.000, < 0.001) compared with COX-2 (AUC 0.734; 95%CI: 0.518-0.950, = 0.057). The optimal VEGF threshold of 221 pg/mL yielded 90% sensitivity and 100% specificity, whereas the COX-2 threshold of 0.675 ng/mL provided 80% sensitivity and 62.5% specificity. These findings indicate that VEGF is a highly promising non-invasive biomarker for assessing endometriosis severity and may support the development of improved diagnostic approaches for endometriosis management. - Source: PubMed
Publication date: 2026/01/13
Aslam AgaRajuddin RajuddinMunizar MunizarRusnaidi RusnaidiHasanuddin Hasanuddin - Endometritis is linked to adverse reproductive outcomes, but epithelial programs in disease initiation and persistence remain unclear. We aimed to systematically define inflammation-associated epithelial states and regulation in endometritis using single-cell analysis. - Source: PubMed
Publication date: 2026/05/14
Tian ChengziLi Zaiyi - Head and neck squamous cell carcinoma (HNSCC) is a highly invasive malignancy driven by complex molecular interactions within the tumour microenvironment (TME). This study aimed to investigate the critical role of MMP1 in HNSCC progression, particularly its interplay with the microbiome and immune remodelling, to uncover potential therapeutic targets. - Source: PubMed
Publication date: 2026/05/14
Mao ChuanqingChen DinghanLai YongzhenLu MengWang Chengyong - To characterize the aqueous humor (AH) cytokine profiles across clinical subtypes of congenital cataracts with posterior polar abnormality (PPA) and to assess their associations with postoperative complications. - Source: PubMed
Zhang QingruoQiu XinyiChung Ka YiZhang JunlinLin ZhuolingLin XiaoshanLin YongbinChen WeirongChen Hui