CD95 _ FAS
- Known as:
- CD95 _ Fas Cell Surface Death Receptor
- Catalog number:
- GTX75106
- Product Quantity:
- 200 µg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- CD95 _ FAS
Related genes to: CD95 _ FAS
- Gene:
- FAS NIH gene
- Name:
- Fas cell surface death receptor
- Previous symbol:
- FAS1, APT1, TNFRSF6
- Synonyms:
- CD95, APO-1
- Chromosome:
- 10q23.31
- Locus Type:
- gene with protein product
- Date approved:
- 1992-06-25
- Date modifiied:
- 2019-04-23
Related products to: CD95 _ FAS
Related articles to: CD95 _ FAS
- Through retrospective analysis, the relationship between formative assessment (FA) and summative assessment (SA) scores in neuroanatomy for doctor of physical therapy (DPT) students (n = 121) was investigated. The study examined if previous academic difficulty impacted the relationship between FA and SA by grouping students with no history of academic challenges into Group 1 (n = 80) and students who experienced previous academic difficulty in coursework into Group 2 (n = 41). The distinction for academic difficulty was defined by programmatic guidelines. Eleven multiple-choice FAs were administered to support preparation for three separate unit SAs. A 1 × 2 multivariate analysis of covariance (MANCOVA) explored the relationship among student groups, FAs, and SAs for Units 2 and 3. Significant relationships were observed between both FA covariates and related SA scores for students in both groups. No significant interaction of student grouping on the relationship between FA and SA scores was observed, thus no differentiated impact of FA scores on SA outcomes between the groups existed. On average, a one-point increase on FA scores was associated with a 2.41-point increase on SA scores in Unit 2 and a one-point increase on FA scores was associated with a 2.54-point increase on SA scores in Unit 3. The study showed FA can benefit all students, positively impacting SA scores regardless of whether students have experienced prior academic challenges. Thus, FA is a valuable instructional tool that can be applied broadly and benefit SA performance for students who experience academic difficulty and those who do not. - Source: PubMed
Publication date: 2026/08/20
Thorp Laura EThames Geoff - The AAA+ protein p97/VCP and its cofactor UFD1/NPL4 interact with and unfold ubiquitinated proteins to promote disaggregation and unfolding for recycling or to prepare substrates for proteasomal degradation. The cofactor Fas-associated factor 1 (FAF1) is suggested to reduce the length of ubiquitin chain required for substrate unfolding by UFD1/NPL4-p97 and to interact with SUMO. Here, we employ in vitro reconstitution of UFD1/NPL4-p97 and FAF1/UFD1/NPL4-p97 complexes and fluorescent substrates modified with SUMO2-polyubiquitin hybrid or polyubiquitin-only chains of varying lengths to assess initial rates of unfolding. These assays reveal that FAF1 enhances initial rates of unfolding relative to UFD1/NPL4-p97 in a manner that is independent of SUMO2 and semi-dependent on ubiquitin chain length. Unlike preferences observed for yeast Ufd1/Npl4-Cdc48, these data suggest that the FAF1 cofactor does not contribute to preferential unfolding of the SUMO2-polyubiquitin substrates tested. Further dissection of FAF1 reveals that it significantly increases the rate of unfolding for all ubiquitin chain lengths tested with its greatest differential impact observed when unfolding chains with four to ten ubiquitin molecules that are considered physiologically relevant. Using cryoEM we resolve a series of reconstructions that reveal FAF1/UFD1/NPL4-p97 bound to substrate in non-translocating and translocating states. Observed interactions between a helix of FAF1 and UFD1 throughout the unfolding process are consistent with AlphaFold models and recent reports suggesting that FAF1 may stabilize interactions between UFD1, NPL4, and p97 to promote substrate engagement and unfolding. - Source: PubMed
Publication date: 2026/08/03
Lemmon Abigail ALima Christopher D - Screening for atherosclerosis is essential for early intervention, but conventional screening methods are often invasive and resource-intensive. As a result, there is growing interest in leveraging AI with noninvasive tools such as retinal fundus imaging to enable opportunistic cardiovascular risk assessment. The deep-learning funduscopic atherosclerosis score (DL-FAS) is an AI-derived biomarker, generated by a deep learning model, that was developed in a previous study to reflect the likelihood of carotid artery atherosclerosis from retinal fundus images. - Source: PubMed
Publication date: 2026/08/19
Han ChanghoChang JooyoungKim JaewonLee HyeokjongKim Kyae HyungCho SeonKwon HeesungKim SuyoungPark Sang Min - HTLV-1 infection causes chronic immune activation and a prolonged asymptomatic phase, but the functional features that define early disease remain unclear. We evaluated whether spontaneous proliferation (SP) and related functional immune parameters can distinguish clinical stages across the HTLV-1 spectrum. Spontaneous and mitogen-induced lymphoproliferation (PHA, anti-CD3), measured by CFSE dilution, and in vitro cell death, measured by cytometry, were assessed in 435 HTLV-1-infected individuals: asymptomatic carriers (AC, n = 303), individuals with intermediate syndrome (IS, n = 21), patients with HTLV-1-associated myelopathy (HAM, n = 94), adult T-cell leukemia/lymphoma (ATL, n = 17), and two control groups. Notably, SP levels divided the asymptomatic individuals in two subgroups: low-SP (24.5%), similar to the control groups, and high-SP (75.5%), resembling IS, HAM, and ATL patients. Additionally, high-SP AC and HTLV-1 symptomatic groups showed significantly reduced responses to PHA and increased spontaneous and PHA-stimulated cell death, all features also observed in IS, HAM, and ATL patients, while low-SP AC results mirrored those of control groups. This increased cell death is strongly correlated with upregulation of Fas and FasL, especially in lymphocytes from high-SP AC, which may underlie the chronic activation and susceptibility to cell death. These findings suggest that HTLV-1 AC comprises two distinct subgroups: one with high SP and cell death, likely due to ongoing viral activity and immune alterations, and another with low SP, low viral activity, and preserved immune homeostasis. Follow up studies of AC with these functional changes are needed to determine if they can help monitor disease progression and identify asymptomatic individuals at higher risk of clinical deterioration. - Source: PubMed
Publication date: 2026/08/19
de Souza Porto MartaMitiko TatianaFolgosi VictorVasconcelos DewtonDomingues MauricioHaziot MichelSmid JerusaMarcusso RosaNukui YoukoOliveira Augusto C PAssone TatianeCasseb JorgeBenard Gil - Human induced pluripotent stem cells (hiPSCs) are a powerful platform for modeling cardiovascular disease (CVD) and developing regenerative therapies, yet progress is limited by variability among hiPSC-derived cardiomyocytes (hiPSC-CMs) and their incomplete metabolic maturation. To address this, maturation schemes supplementing the fatty acids (FAs) palmitate (PA) and oleate (OA) have been shown to promote a more aerobic phenotype, though outcomes vary due to intrinsic hiPSC-CM heterogeneity. While donor-related factors such as age and somatic origin have been studied, the influence of sex remains largely unexplored despite its role in adult cardiac metabolism. Here, we investigate allosome-driven contributions to hiPSC-CM metabolic and functional diversity. Using three male and three female hiPSC lines, we evaluate whether sex modulates hiPSC-CM responses to PA or OA. Our results reveal modest sex differences at baseline, but pronounced divergence following FA treatment in contractility, aerobic metabolism, and transcriptomic profiles. These findings inform the development of maturation strategies by highlighting sex-specific regulation of hiPSC-CM metabolism and function. - Source: PubMed
Publication date: 2026/08/19
McClain Anna KCallahan CodyShelke Saivee SShir RoniGivens Sophie EOgle Brenda MZoldan Janet