NATIVE STAPHYLOCOCCUS AUREUS PROTEIN A, Product Type Purified Protein, Specificity PROTEIN A, Target Species Bacterial, Host N_A, Format Purified, Isotypes , Applications IP, Clone
- Known as:
- NATIVE STAPHYLOCOCCUS AUREUS PROTEIN A, Product Type Purified Protein, Specificity PROTEIN A, Target Species Bacterial, Host N_A, Format Purified, Isotypes , Applications IP, Clone
- Catalog number:
- 7840-0604
- Product Quantity:
- 5 mg
- Category:
- -
- Supplier:
- AbD
- Gene target:
- NATIVE STAPHYLOCOCCUS AUREUS PROTEIN Product Type Purified Protein Specificity Target Species Bacterial Host N_A Format Isotypes Applications Clone
Related genes to: NATIVE STAPHYLOCOCCUS AUREUS PROTEIN A, Product Type Purified Protein, Specificity PROTEIN A, Target Species Bacterial, Host N_A, Format Purified, Isotypes , Applications IP, Clone
- Gene:
- TYRP1 NIH gene
- Name:
- tyrosinase related protein 1
- Previous symbol:
- TYRP, CAS2
- Synonyms:
- GP75, CATB, TRP, b-PROTEIN, OCA3
- Chromosome:
- 9p23
- Locus Type:
- gene with protein product
- Date approved:
- 1991-09-04
- Date modifiied:
- 2016-04-19
Related products to: NATIVE STAPHYLOCOCCUS AUREUS PROTEIN A, Product Type Purified Protein, Specificity PROTEIN A, Target Species Bacterial, Host N_A, Format Purified, Isotypes , Applications IP, Clone
Related articles to: NATIVE STAPHYLOCOCCUS AUREUS PROTEIN A, Product Type Purified Protein, Specificity PROTEIN A, Target Species Bacterial, Host N_A, Format Purified, Isotypes , Applications IP, Clone
- Thiosemicarbazones have been widely used due to their various biological activities and interesting NLO behavior. In this study, the thione and thiol tautomers of [(E)-1-[4-[(2,4-dihydroxyphenyl) diazenyl] phenyl] ethylideneamino] thiourea have been studied at the DFT level of theory using BVP86/6-311G(d,p), coupled with molecular docking against tyrosinase, BRAF, and MEK1. The thione tautomer displayed a smaller HOMO-LUMO gap (1.780 eV), greater electrophilicity (9.52 eV), and enhanced NLO characteristics (static β = 134.525 × 10 esu, dynamic β = 3192.119 × 10 esu), along with enhanced binding affinity towards TYRP1 (-8.1 kcal/mol), and inhibitory activity against BRAF (Kᵢ = 0.214 μM), and MEK1 (Kᵢ = 0.497 μM). Based on these results, it is evident that the thione tautomer is a suitable candidate for development as a dual-inhibitor of the tyrosinase/kinase pathways, which can be used for melanoma treatment and also for optoelectronic applications. This work provides the link between theoretical predictions and experimental drug design and forms the basis for future syntheses of thiosemicarbazone-based drugs. - Source: PubMed
Publication date: 2026/08/25
Benhalima NadiaYahia Cherif FatimaKhelloul NawelSindi Emad RashadMoussa Sana BenAlzahrani Abdullah Yahya AbdullahKhelifaoui AhmedUddin Mohammad BorhanAbdelkrim GuendouziZaki Magdi E A - Guangxi Bama miniature pigs are a highly inbred population developed from Bama Xiang pigs and exhibit a stable "two-end black" skin phenotype, making them a useful model for studying regional skin pigmentation. However, the developmental timing and molecular basis of this color difference remain unclear. In this study, black and white skin samples were collected from the posterior head/neck region at six developmental stages: embryonic days 65, 90, and 105, birth, and postnatal days 30 and 180. Histological examination and strand-specific RNA sequencing showed that developmental stage was the major factor shaping skin gene expression, whereas black-white skin differences varied across stages. Transcriptomic differences were already detectable at embryonic day 65, although visible regional differences were not obvious. Pigmentation-associated genes, including , , , and , showed black-skin-biased expression during embryonic development, especially at embryonic day 105. Histological analysis also revealed progressive skin maturation and qualitative differences in darkly stained structures between black and white skin. These findings suggest that molecular differences between black and white skin emerge during embryonic development and persist after birth, providing resources and candidate genes for studying regional pigmentation in Bama miniature pigs. - Source: PubMed
Publication date: 2026/08/17
Feng LingliXia QinXu WenwenDeng ZhongrongAbla AlidaLi JiafuLiang JinningZhang YanpingGuo XiaopingLiang Jing - Abnormal skin pigmentation is a common clinical dermatological issue, and its occurrence and development are closely associated with the inflammatory microenvironment. However, the interactive regulatory mechanisms between inflammatory factors and melanogenesis remain incompletely understood. In this study, through the analysis of transcriptomic data from melasma, psoriasis, acne, atopic dermatitis, and ultraviolet-irradiated skin tissues, we found that CXCL1 may negatively regulate melanogenesis. To validate this finding, we exogenously treated human primary melanocytes, MNT1 cells, and ex vivo human foreskin tissues with CXCL1. The results showed that CXCL1 reduced melanin content, tyrosinase activity, and the expression of key melanogenesis-related genes, including MITF, TYR, TYRP1, and DCT. Mechanistic studies revealed that CXCL1 exerts these inhibitory effects through its canonical receptor CXCR2. Notably, CXCL1 treatment significantly decreased both the expression level and nuclear translocation of β-catenin, a key effector molecule of the WNT signaling pathway, and this effect was effectively reversed by the specific CXCR2 inhibitor SB225002, suggesting that the CXCL1-CXCR2 axis negatively regulates melanogenesis by suppressing the WNT/β-catenin signaling pathway. In summary, this study elucidates a preliminary mechanism by which the CXCL1-CXCR2 axis negatively regulates melanogenesis through inhibition of the WNT/β-catenin signaling pathway, linking inflammatory cytokine networks to the regulatory machinery of melanogenesis. It provides novel perspectives for deciphering the pathogenesis of pigmentary skin disorders and developing therapeutic strategies with combined anti-inflammatory and depigmenting effects. - Source: PubMed
Publication date: 2026/07/31
Zhang YushanZhang FanYu XiaoyuanZhao XiaojiaoChen JingZhu JianjianKang Liyang - To investigate the regulatory effects of repeated low-level red light (RLRL) on refractive development in guinea pigs with different refractive states and to explore the underlying mechanisms. - Source: PubMed
Publication date: 2026/08/12
Liu TiangeLi ZhenLiu QiweiHan YufengHe SiyuanChun KongyiYam Jason C SLi XiaotongZhang Wei - Clinically refractory melasma remains difficult to treat because it is driven by a multidimensional pathological microenvironment that includes melanocyte hyperactivity, aberrant vascular growth, oxidative stress and chronic inflammation. Single-pathway therapies therefore often produce incomplete or transient responses. To remodel this microenvironment more broadly, we developed a bioinspired, stimulus-responsive co-delivery microneedle platform (TXA/Exo@HAMA-PBA MNs). Inspired by the backward-curved barbs on the tick hypostome, the microneedles were engineered with outward-facing barbs to improve anchoring within skin tissue. Chemically, adipose-derived stem cell exosomes (ADSC-Exos) acted as bioactive crosslinking nodes. They were coupled to the HAMA-PBA matrix through ROS-sensitive dynamic boronate ester bonds, while tranexamic acid (TXA) was physically co-encapsulated. After insertion into ROS-rich melasma-like lesions, oxidative cleavage of carbon-boron bonds accelerated matrix degradation and promoted on-demand release of both payloads. Mechanistically, this platform produced an asymmetric but coordinated blockade of the pathological microenvironment: ADSC-Exos mainly scavenged local ROS, including ·OH, whereas TXA preferentially disrupted abnormal capillary networks. Together, they suppressed melanogenesis through the MITF/TYRP1 cascade and shifted macrophages from a pro-inflammatory M1 phenotype towards a tissue-reparative M2 phenotype. In a UV/progesterone-induced mouse model of melasma validated by bulk RNA sequencing, the system produced multidimensional microenvironmental regulation and visible depigmentation. This bioinspired, spatiotemporally responsive co-delivery microneedle platform integrates complementary and synergistic therapeutic actions and offers a translational strategy for complex, multifactorial hyperpigmentary disorders. - Source: PubMed
Publication date: 2026/07/28
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